Regular endurance training in adolescents impacts atrial and ventricular size and function

Rundqvist, Louise; Engvall, Jan; Faresjö, Maria; Carlsson, Enar; Blomstrand, Peter

doi:10.1093/ehjci/jew150

Cited by 23 publications

(84 citation statements)

References 33 publications

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“…In our earlier study, we found a strong correlation between VO 2max and resting cardiac dimensions, and an additionally but weaker correlation to resting RV function (Rundqvist et al, 2016). In our present study, where we assessed the correlation of VO 2max and cardiac parameters immediately after a short maximal exercise test, we demonstrate that LA volume and systolic function such as LVEF were positively correlated to VO 2max , but the strongest correlation to VO 2max was found in LV volume and E/e 0 .…”

Section: Linear Regressionmentioning

confidence: 62%

“…Recently, we demonstrated considerable cardiac structural remodelling at rest in endurance trained adolescents compared to controls (Rundqvist et al, 2016), suggesting that long-term effects of regular exercise obviously affect cardiac morphology to a higher extent than cardiac function. We found similar responses to exercise in systolic and diastolic parameters in general for both the active and the control groups.…”

Section: Discussionmentioning

confidence: 94%

“…That may indicate that the functional response to a short exercise session not is dependent on the degree of endurance training. Recently, we demonstrated considerable cardiac structural remodelling at rest in endurance trained adolescents compared to controls (Rundqvist et al, 2016), suggesting that long-term effects of regular exercise obviously affect cardiac morphology to a higher extent than cardiac function. Systolic parameters of LV function, such as LVEF, LVGLS, LV strain rate, and septal and lateral LV s 0 , were all increased immediately after exercise in both groups compared to baseline, which is consistent with previous studies in both adults and a healthy paediatric cohort (La Gerche et al, 2012b;Cifra et al, 2016), indicating an increased myocardial contractility.…”

Section: Discussionmentioning

confidence: 94%

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Left ventricular diastolic function is enhanced after peak exercise in endurance‐trained adolescents as well as in their non‐trained controls

Rundqvist

Engvall²,

Faresjö

et al. 2018

Clin Physio Funct Imaging

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The aims of the study were to explore the temporal change of cardiac function after peak exercise in adolescents, and to investigate how these functional changes relate to maximal oxygen uptake (VO ). The cohort consisted of 27 endurance-trained adolescents aged 13-19 years, and 27 controls individually matched by age and gender. Standard echocardiography and colour tissue Doppler were performed at rest, and immediately after as well as 15 min after a maximal cardio pulmonary exercise test (CPET) on a treadmill. The changes in systolic and diastolic parameters after exercise compared to baseline were similar in both groups. The septal E/e'-ratio increased immediately after exercise in both the active and the control groups (from 9·2 to 11·0; P<0·001, and from 8·7 to 10·2; P = 0·008, respectively). In a comparison between the two groups after CPET, the septal E/e'-ratio was higher in the active group both immediately after exercise and 15 min later compared to the control group (P = 0·007 and P = 0·006, respectively). We demonstrated a positive correlation between VO and cardiac function including LVEF and E/e' immediately after CPET, but the strongest correlation was found between VO and LVEDV (r = 0·67, P<0·001) as well as septal E/e' (r = 0·34, P = 0·013). Enhanced diastolic function was found in both groups, but this was more pronounced in active adolescents. The cardiac functional response to exercise, in terms of LVEF and E/e', correlates with the increase in VO uptake. These findings in trained as well as un-trained teenagers have practical implications when assessing cardiac function.

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Section: Linear Regressionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 94%

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Left ventricular diastolic function is enhanced after peak exercise in endurance‐trained adolescents as well as in their non‐trained controls

Rundqvist

Engvall²,

Faresjö

et al. 2018

Clin Physio Funct Imaging

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View full text Add to dashboard Cite

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“…5,38 In parallel with our results, more pronounced LV and LA morphologic remodeling was found to be associated with better exercise capacity in echocardiographic studies as well. 5,39 Interestingly, fewer data are available about the relationship between cardiac function and exercise capacity. La Gerche et al 5 demonstrated an inverse correlation between LVEF and VO 2 /kg, but they did not find a relationship between LV deformation parameters and exercise performance.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Cardiac Remodeling and Exercise Capacity in Elite Athletes: Incremental Value of Left Atrial Morphology and Function Assessed by Three-Dimensional Echocardiography

Lakatos

Molnár

Kiss

et al. 2020

Journal of the American Society of Echocardiography

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Background: Data are scarce regarding left atrial (LA) adaptation to regular physical exercise. The aim of this study was to examine left ventricular (LV) and also LA morphologic and functional remodeling in elite athletes using three-dimensional (3D) echocardiography. Methods: In this retrospective analysis, the study group consisted of 138 elite athletes (mean age, 20 6 4 years; 62% men) and 50 sedentary control subjects. Electrocardiographically gated full-volume 3D data sets were obtained for offline analysis using dedicated software for 3D LA and LV measurements. Body surface areaindexed LA maximal volume (LAVmax) and LV end-diastolic volume were determined. LA total emptying fraction, LA passive and LA active emptying fraction, and LV global longitudinal strain were also calculated. Athletes also underwent cardiopulmonary exercise testing to determine peak oxygen uptake. Results: Athletes demonstrated higher 3D LAVmax (32 6 6 vs 26 6 8 mL/m 2) and indexed LV end-diastolic volume (85 6 12 vs 62 6 10 mL/m 2) compared with control subjects (P < .001 for both). Functional measures of the left ventricle and left atrium, such as the absolute value of 3D LV global longitudinal strain (19 6 2% vs 22 6 2%), LA total emptying fraction (58 6 6% vs 64 6 6%), and active emptying fraction (24 6 10% vs 32 6 10%) were lower in athletes (P < .001 for all). Male athletes had higher indexed LV end-diastolic volume compared with female athletes (89 6 13 vs 80 6 8 mL/m 2 , P < .001), but LAVmax did not differ between genders (32 6 6 vs 33 6 5 mL/m 2 , P = .18). Besides heart rate, gender, and body surface area, 3D LAVmax, LV global longitudinal strain, and LA passive emptying fraction were independent predictors of peak oxygen uptake. Conclusions: Regular physical exercise results in marked LA and LV remodeling with considerable gender differences as explored by 3D echocardiography. In contrast with various cardiovascular diseases, more pronounced LA dilation and lower resting functional measures are associated with better exercise performance.

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“…This is contradictory to what has been seen in young healthy individuals and also in an animal model of chronic obstructive pulmonary disease-induced PH. 38 , 39 However, the effects of exercise training on TAPSE in PH are yet to be explored.…”

Section: Discussionmentioning

confidence: 99%

Effects of home-based exercise training on functional outcomes and quality of life in patients with pulmonary hypertension: A randomized clinical trial

Babu

Padmakumar

Nayak

et al. 2019

Indian Heart Journal

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Objectives The objective of this study was to assess the effects of home-based exercise training (HBET) on function and quality of life (QoL) in patients with pulmonary hypertension (PH). Methods A prospective, nonblinded, randomized clinical trial was carried out on 84 medically stable patients with PH belonging to any functional class or etiology and of either sex. Patients were randomized to either standard care or HBET. Both groups also received education using the Pulmonary Hypertension Manual (PulHMan). Outcomes included functional capacity from 6-min walk distance (6MWD), QoL using the Medical Outcomes Survey Short Form – 36, functional class (FC), and right heart indices (right ventricular systolic pressure [RVSP] and tricuspid annular plane systolic excursion [TAPSE]) and were assessed at entry and after 12 weeks. Results HBET improved 6MWD by 48.5 m and 13 m in the experimental and control groups, respectively ( p < 0.001). QoL showed statistical improvements after HBET between the groups for the physical and mental components and for the various subdomains (except body pain). Furthermore, FC improved by one grade with HBET ( p < 0.001). Conclusion HBET program improved functional capacity, QoL, and FC in patients with PH.

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Regular endurance training in adolescents impacts atrial and ventricular size and function

Cited by 23 publications

References 33 publications

Left ventricular diastolic function is enhanced after peak exercise in endurance‐trained adolescents as well as in their non‐trained controls

Left ventricular diastolic function is enhanced after peak exercise in endurance‐trained adolescents as well as in their non‐trained controls

Relationship between Cardiac Remodeling and Exercise Capacity in Elite Athletes: Incremental Value of Left Atrial Morphology and Function Assessed by Three-Dimensional Echocardiography

Effects of home-based exercise training on functional outcomes and quality of life in patients with pulmonary hypertension: A randomized clinical trial

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