“…In humans, exercise is associated with a reduced incidence of stress-related psychopathology (De Moor et al, 2006;Dunn et al, 2001;Herring et al, 2010;Lawlor and Hopker, 2001), and in rodents, voluntary wheel running is associated with reduced anxiety-and depression-like behaviors (Binder et al, 2004;Fox et al, 2008;Greenwood et al, 2005;Greenwood et al, 2003;Salam et al, 2009;Sciolino et al, 2012). For example, we have shown that 2 weeks of home cage wheel running in C57BL/6J mice reduces acoustic startle amplitude, reduces stress-induced hyperthermia, diminishes anxiety-like behavior in the open field, and reduces the anxiogenic effect of the serotonin agonist m-chlorophenylpiperazine (mCPP, Fox et al, 2008;Salam et al, 2009).…”