Regular intake of white kidney beans extract (Phaseolus vulgaris L.) induces weight loss compared to placebo in obese human subjects

Abstract

Scope Phaseolus vulgaris L. is rich in alpha‐amylase inhibitor and has been used for reducing glycemia and calories absorption through preventing or delaying the digestion of complex carbohydrate. A randomized, double‐blinded, placebo‐controlled study was conducted on obese volunteers to evaluate the degree of significate weight loss by regular intake Phaseolus vulgaris cultivated from Southwestern region of China. Method The volunteers were divided into two groups, homogeneous for age, gender, and body weight. Phaseolus vulgaris extract or placebo was given 2,400 mg per day before each daily meal for 35 consecutive days. Each subject's body weight, fat mass, body mass index, blood biochemical parameters, skinfold fat thickness, and waist/hip circumferences were monitored and analyzed. Result and conclusion As a result, the average amount of weight lost by the Phaseolus vulgaris extract group was 2.24 kg (average of 0.448 kg per week), compared with a 0.29 kg weight loss (average of 0.058 kg per week) in placebo group after 35 days. The differences between groups were significant (p < .01). The body mass index decreased by an average of 0.79, and the body fat decreased by 1.53% on average compared to baseline (p < .05). The thickness of subcutaneous fat was significantly reduced at the four measurement points, and the decrease of waist circumference and hip circumference was significant as well. No adverse or side effects were observed during the trial period. The results indicate that Phaseolus vulgaris extract can significantly induce weight loss in a short time period.

Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review

“…Barrett et al systematically reviewed ten studies conducted between 2000 and 2010 evaluating the effect of Phase 2 ® products on body weight and glycemic control in subjects with overweight and obesity, demonstrating significant weight loss when the product was taken concurrently with carbohydrate containing meals. A recent metanalysis confirmed Phase2 ® PVE efficacy on body weight and fat change [65], results being confirmed by a recent Chinese RCT involving 120 subjects with obesity, in which the group treated with PVE capsules experienced a mean placebo adjusted weight loss of 1.95 kg after 35 days [66]. Conversely, another metanalysis conducted by Onakpoya et al including all kinds of PVE commercial products concluded for a substantial absence of efficacy of these towards weight loss outcomes [67].…”

Comprehensive Study of Scientific Evidence and Potential Risk of Herbal Medicine Use for Body Weight Reduction in North West Saudi Arabia

“…Some of the remedies used in Tabuk area were previously approved for their efficacy in reducing weight such as ginger [10], cinnamon [11], green tea [12], coffee beans [13], chili [14], hibiscus [15], curcumin [16], kidney beans [17], and cumin [18]. We want to add that most of the studies on weight reduction remedies were performed only on animals, and very little studies were performed on humans.…”

It’s No Has Bean: A Review of the Effects of White Kidney Bean Extract on Body Composition and Metabolic Health

“…In the most recent study, Wang et al [ 58 ] reported that obese participants supplemented with 2400 mg WKBE/day achieved a significant loss of weight and fat mass by, on average, −2.2 kg and −2.0 kg, respectively, following a 35-day intervention; this differed significantly from that reported in the placebo group. The reductions in the overweight percentage, BMI and body fat percentage were also significantly greater in the treatment group vs. the placebo group.…”

“…The haematology results from the most recent human study, including the red blood cell count, white blood cell count, platelet count and haemoglobin, did not change significantly with WKBE supplementation for 35 days, nor did they differ significantly from those given the placebo [ 58 ]. Likewise, serum biochemical parameters, including the total serum protein, albumin, glucose, uric acid and creatinine, did not change and remained within the normal ranges for these markers after a 35-day WKBE intervention in obese subjects, demonstrating the safety of WKBE.…”

“…To date, a small number of studies have investigated the effects of WKBE on blood pressure [ 50 , 54 , 56 , 58 ]. Improvements in systolic and diastolic blood pressures of −5.6 and −3.9 mmHg, respectively, were reported following a 84-day supplementation with WKBE compared with the placebo [ 54 ].…”