Regular RNA screening detects asymptomatic SARS-CoV-2 infection in haemodialysis patients

Storey, Ben; Bottomley, Matthew J.; Hammad, Salim; Thornley, Allie; Barrett, Lucinda; O’Sullivan, Oliver; Bull, Katherine

doi:10.1093/ndt/gfab044

Cited by 4 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We note a study from Oxford that was performed over a similar time period as our study found a prevalence of 1.8% of asymptomatic disease. 84 A study from Canada, which had a case:population ratio similar to that of the UK over the same period reported even lower rates. 85 We also note a study from London which quoted a prevalence of 12% of asymptomatic patients, but are aware the case burden of COVID-19 early in the pandemic was much higher in the capital than it was in the Midlands.…”

Section: Discussionmentioning

confidence: 95%

Risk factors associated with COVID-19 severity among patients on maintenance haemodialysis: a retrospective multicentre cross-sectional study in the UK

et al. 2022

View full text Add to dashboard Cite

ObjectivesTo assess the applicability of risk factors for severe COVID-19 defined in the general population for patients on haemodialysis.SettingA retrospective cross-sectional study performed across thirty four haemodialysis units in midlands of the UK.ParticipantsAll 274 patients on maintenance haemodialysis who tested positive for SARS-CoV-2 on PCR testing between March and August 2020, in participating haemodialysis centres.ExposureThe utility of obesity, diabetes status, ethnicity, Charlson Comorbidity Index (CCI) and socioeconomic deprivation scores were investigated as risk factors for severe COVID-19.Main outcomes and measuresSevere COVID-19, defined as requiring supplemental oxygen or respiratory support, or a C reactive protein of ≥75 mg/dL (RECOVERY trial definitions), and its association with obesity, diabetes status, ethnicity, CCI, and socioeconomic deprivation.Results63.5% (174/274 patients) developed severe disease. Socioeconomic deprivation associated with severity, being most pronounced between the most and least deprived quartiles (OR 2.81, 95% CI 1.22 to 6.47, p=0.015), after adjusting for age, sex and ethnicity. There was no association between obesity, diabetes status, ethnicity or CCI with COVID-19 severity. We found no evidence of temporal evolution of cases (p=0.209) or clustering that would impact our findings.ConclusionThe incidence of severe COVID-19 is high among patients on haemodialysis; this cohort should be considered high risk. There was strong evidence of an association between socioeconomic deprivation and COVID-19 severity. Other risk factors that apply to the general population may not apply to this cohort.

show abstract

Section: Discussionmentioning

confidence: 95%

Risk factors associated with COVID-19 severity among patients on maintenance haemodialysis: a retrospective multicentre cross-sectional study in the UK

et al. 2022

View full text Add to dashboard Cite

show abstract

“…19 Nosocomial infections due to COVID-19 are not easy to prevent, and it remains difficult to immediately control the spread without proper intervention measures. Several studies have suggested that routine monitoring of COVID-19 transmission should be carried out for high-risk groups, such as patients receiving hemodialysis 20,21 and patients hospitalized for hemato-oncological diseases. [22][23][24] Other vulnerable patients, such as those in the intensive care units, may also require special attention.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 Screening for Hospitalized Patients: The Role of Expanded Hospital Surveillance in a Low Prevalence Setting

Hsu¹,

Liu²,

Tseng³

et al. 2021

JMDH

View full text Add to dashboard Cite

Purpose:The COVID-19 pandemic poses a serious threat to healthcare workers and hospitalized patients. Early detection of COVID-19 cases is essential to control the spread in healthcare facilities. However, real-world data on the screening criteria for hospitalized patients remain scarce. We aimed to explore whether patients with negative results of prehospital screening for COVID-19 should be rescreened after admission in a low-prevalence (less than 3% of the world average) setting. Patients and Methods:We retrospectively included patients in central Taiwan who were negative at the first screening but were newly diagnosed with pneumonia or had a body temperature above 38 degrees Celsius during their hospitalization. Each patient might be included as an eligible case several times, and the proportions of cases who were rescreened for COVID-19 and those diagnosed with COVID-19 were calculated. A logistic regression model was constructed to identify factors associated with rescreening. Reverse transcriptionpolymerase chain reaction tests were used to confirm the diagnosis of COVID-19. Results: A total of 3549 cases eligible for COVID-19 rescreening were included. There were 242 cases (6.8%) who received rescreening. In the multivariable analysis, cases aged 75 years or older, those with potential exposure to SARS-CoV-2, or patients visiting specific departments, such as the Cardiovascular Center and Department of Neurology, were more likely to be rescreened. None was diagnosed with COVID-19 after rescreening. There was no known cluster infection outbreak in the hospital or in the local community during the study period and in the following two months. Conclusion:In Taiwan, a country with a low COVID-19 prevalence, it was deemed safe to rescreen only high-risk hospitalized patients. This strategy was effective and reduced unnecessary costs.

show abstract

“…We report a high rate of re-infection with SARS-CoV-2 (22%) prior to vaccination within patients who had ESRD, the majority of whom could not effectively shield during the pandemic due to the requirement of in-hospital haemodialysis, 2-3 visits/week. Our higher estimate for re-infection rate may reflect early adoption of asymptomatic PCR screening in the hospital haemodialysis cohort in our region (26). Whilst all ESRD patients who survived SARS-CoV-2 infection demonstrated detectable levels of IgG titres to Spike and S1 RBD, and/or mounted antigen-specific CD4 + and CD8 + T cell responses, some of these responses were lower than those of healthy albeit younger control cohorts There were no differences in cellular or humoral responses between HD and pharmacologically immunosuppressed transplant patients, emphasising the poor qualitative immune responses of the HD cohort.…”

Section: Discussionmentioning

confidence: 81%

Poor Antibody Responses to SARS-CoV-2 Infection or Vaccination Are Associated With High Re-Infection Rates in Haemodialysis and Renal Transplant Patients

et al. 2021

View full text Add to dashboard Cite

Regular RNA screening detects asymptomatic SARS-CoV-2 infection in haemodialysis patients

Cited by 4 publications

References 12 publications

Risk factors associated with COVID-19 severity among patients on maintenance haemodialysis: a retrospective multicentre cross-sectional study in the UK

Risk factors associated with COVID-19 severity among patients on maintenance haemodialysis: a retrospective multicentre cross-sectional study in the UK

COVID-19 Screening for Hospitalized Patients: The Role of Expanded Hospital Surveillance in a Low Prevalence Setting

Poor Antibody Responses to SARS-CoV-2 Infection or Vaccination Are Associated With High Re-Infection Rates in Haemodialysis and Renal Transplant Patients

Contact Info

Product

Resources

About