Regular supervised fluoride mouthrinse use by children and adolescents associated with caries reduction

Shahid, Mishel

doi:10.1038/sj.ebd.6401217

Cited by 18 publications

(14 citation statements)

References 1 publication

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“…2,3 Their use helps to reduce caries, dental plaque and gingivitis with respect to dental, gingival and oral mucosal tissues. 4,5 Moreover, they support treating those tooth surfaces that are inaccessible by MOH. 2 They also have a high level of acceptance among the public due to their ease of use and breath-freshening effect.…”

Section: Introductionmentioning

confidence: 89%

Adverse events associated with home use of mouthrinses: a systematic review

Tartaglia

Tadakamadla

Connelly

et al. 2019

Therapeutic Advances in Drug Safety

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Background: Poor oral hygiene is strongly associated with oral and systemic diseases. Alongside mechanical tooth cleaning, the adjunctive use of mouthrinses has been widely advocated. Although research on the efficacy of various mouthrinse formulations is very active, there are a lack of conclusive data regarding their adverse effects. Methods: We undertook a systematic review in accordance wih PRISMA guidelines of electronic databases of clinical trials of any duration with daily home use of mouthwashes, presenting clinical and subjective side effects (PROSPERO registration: CRD42016054037). Results: After evaluating 614 titles and abstracts, 154 studies were selected for full-text analysis; 85 final papers were included. Based on the active ingredient in the test product, nine categories were created: cetyl pyridinium chloride, essential oils, chlorhexidine, triclosan, natural products, diclofenac, fluorides, delmopinol, and miscellaneous active substances. Most of the studies were of short duration (less than 6 months) with a defective ‘methods’ description; the reporting of adverse events often being overlooked. Both local morphological (oral mucosa and dental-crown staining, mucosal lesions) and functional (taste modifications, abnormal oral sensation) alterations were reported. Tooth staining was the most commonly listed adverse event, but it was quantitatively assessed only in a very small number of papers; most studies relied on patient reports. Staining was time associated; the longer the study, the higher its reported incidence and severity. Conclusions: The reduced report of side effects may partly be due to a lack of an objective measure and lack of general guidelines that demand studies report their adverse events. The most frequently reported adverse effect was teeth staining. As in most studies, the effect was associated with trial duration; clinical trials should be of sufficient duration. New investigations meeting the suggested criteria of a minimal duration of 6 months should be planned.

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Section: Introductionmentioning

confidence: 89%

Adverse events associated with home use of mouthrinses: a systematic review

Tartaglia

Tadakamadla

Connelly

et al. 2019

Therapeutic Advances in Drug Safety

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“…Although fluoride interventions seem to have the most consistent benefit in preventing caries development and remineralizing initial lesions with the highest level of supporting evidence, 6–8 caries still develop in high risk individuals of all ages, irrespective of the dose of fluoride used. 9,10 There are limitations to what application of fluoride alone can achieve in relation to caries prevention and remineralization.…”

Section: Introductionmentioning

confidence: 99%

Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children

et al. 2019

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ObjectiveThis in situ study compared the effectiveness of two toothpastes containing hydroxyapatite or 500 ppm fluoride in promoting remineralization and inhibiting caries development.Materials and methodsTwo enamel blocks (human primary teeth), one sound and one with artificially-produced caries lesion, were exposed to toothpaste containing either 10% hydroxyapatite or 500 ppm F− (amine fluoride) via intra-oral appliance worn by 30 adults in two-arm double blind randomized crossover study lasting 14 days per arm (ClinicalTrials.gov: NCT03681340). Baseline and post-test mineral loss and lesion depth (LD) were quantified using microradiography. One-sided t-test of one group mean was used for intragroup comparison (baseline vs. post-test), while two-sided t-test of two independent means was used to compare the two toothpaste groups.ResultsPairwise comparison (baseline vs. test) indicated significant (p < 0.0001) remineralization and LD reduction by either toothpaste; however, when compared against each other, there was no statistically significant difference in remineralization or LD reduction between the two toothpastes. No demineralization could be observed in sound enamel blocks exposed to either toothpaste. While F− induced lesion surface lamination, HAP produced a more homogenous lesion remineralization.Conclusions10% hydroxyapatite achieved comparable efficacy with 500 ppm F− in remineralizing initial caries and preventing demineralization. Thus the HAP toothpaste is confirmed to be equal to the fluoride toothpaste in this study.

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“…The dramatic decline in caries prevalence rates of developed countries from the latter half of the 20th century has been largely attributed to the widespread use of oral care products containing fluoride [Fejerskov, 2004]. Fluoride remains the gold standard for arresting caries lesions with multiple systematic reviews confirming the role of fluoride products in preventing dental caries [Benson et al, 2013;Marinho et al, 2003Marinho et al, , 2015Marinho et al, , 2016Shahid, 2017]. However, emerging epidemiological data are showing a worrying trend, with caries experience plateauing or even increasing in some population groups, despite the regular use of fluoride dentifrices in these countries [Agustsdottir et al, 2010;AIHW, 2018;Dye et al, 2017;Haugejorden and Birkeland, 2005].…”

Section: Fluoride -Improving Its Efficacy and Safetymentioning

confidence: 99%

State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management

Philip

2018

Caries Res

237

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The principles of minimally invasive dentistry clearly dictate the need for clinically effective measures to remineralize early enamel caries lesions. While fluoride-mediated remineralization is the cornerstone of current caries management philosophies, a number of new remineralization strategies have been commercialized or are under development that claim to promote deeper remineralization of lesions, reduce the potential risks associated with high-fluoride oral care products, and facilitate caries control over a lifetime. These non-fluoride remineralizing systems can be broadly categorized into biomimetic enamel regenerative technologies and the approaches that repair caries lesions by enhancing fluoride efficacy. This paper discusses the rationale for non-fluoride remineralization and the mechanism of action, challenges, and evidence behind some of the most promising advances in enamel remineralization therapies.

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Regular supervised fluoride mouthrinse use by children and adolescents associated with caries reduction

Cited by 18 publications

References 1 publication

Adverse events associated with home use of mouthrinses: a systematic review

Adverse events associated with home use of mouthrinses: a systematic review

Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children

State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management

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