2021
DOI: 10.1016/j.bbi.2021.05.002
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Regular swimming exercise prevented the acute and persistent mechanical muscle hyperalgesia by modulation of macrophages phenotypes and inflammatory cytokines via PPARγ receptors

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Cited by 12 publications
(19 citation statements)
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“…Macrophages are plastic and change their phenotype in response to the external environment; the current study shows an increase in proportion of M1 macrophages in the muscle after induction of muscle pain in sedentary mice. This is in agreement with prior work showing an increase in M1 macrophages in the muscles of sedentary mice following injection of carrageenan ( 13 ). M1 macrophages release pro-inflammatory cytokines while M2 release antiinflammatory cytokines.…”
Section: Discussionsupporting
confidence: 93%
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“…Macrophages are plastic and change their phenotype in response to the external environment; the current study shows an increase in proportion of M1 macrophages in the muscle after induction of muscle pain in sedentary mice. This is in agreement with prior work showing an increase in M1 macrophages in the muscles of sedentary mice following injection of carrageenan ( 13 ). M1 macrophages release pro-inflammatory cytokines while M2 release antiinflammatory cytokines.…”
Section: Discussionsupporting
confidence: 93%
“…The current study also showed prior physical activity results in a higher proportion of macrophages demonstrating the M2 and M0 phenotype, and a lower proportion of the M1 phenotype, in the gastrocnemius muscle after induction of the pain model in both males and females. This agrees with prior work which showed increases in the M2 macrophage phenotype in muscle from uninjured animals and increases in M2 and decreases in M1 phenotypes in the muscle or at the site of nerve injury after exercise ( 13, 15, 17, 79 ). The higher proportion of antiinflammatory M2 macrophages could account for the attenuated immune response observed with RNA sequencing since M2 macrophages secrete anti-inflammatory cytokines such as IL-10 which protects against development of pain in several animal models ( 13, 15, 17, 8083 ).…”
Section: Discussionsupporting
confidence: 93%
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