Regular use of aspirin or acetaminophen and risk of non-Hodgkin lymphoma

Baker, Julie; Weiss, Joli; Czuczman, Myron S.; Menezes, Ravi; Ambrosone, Christine B.; Moysich, Kirsten B.

doi:10.1007/s10552-004-3074-9

Cited by 32 publications

(23 citation statements)

References 37 publications

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“…Some prospective cohort and case-control studies analyzed the association between aspirin and non-aspirin NSAID use and risk of NHL with contradictory results. An inverse association was documented in a population-based casecontrol study (OR=0.72; 95% CI= 0.56-0.91) (Holly et al, 1999) and a near significant association between regular use of aspirin and moderate decrease of NHL has also been reported in another hospital-based case-control study in men (OR= 0.82; 95% CI= 0.65-1.04), while women who used acetaminophen regularly experienced a 71% elevation in the risk of B-cell NHL (OR= 1.71; 95% CI 1.18-2.50) (Baker et al, 2005). A potential protective effect of analgesic use on NHL risk in women but not in men has also been reported (Beiderbeck et al, 2003).…”

Section: Nsaids and Steroidssupporting

confidence: 66%

Autoimmune Disorders and Lymphomas

Dolcetti¹,

Ponzoni²,

Mappa³

et al. 2011

Autoimmune Disorders - Pathogenetic Aspects

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Section: Nsaids and Steroidssupporting

confidence: 66%

Autoimmune Disorders and Lymphomas

Dolcetti¹,

Ponzoni²,

Mappa³

et al. 2011

Autoimmune Disorders - Pathogenetic Aspects

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“…5). In general, previous cohort studies reported positive (4,5,7) or null (19,20) associations between NSAID use and NHL whereas most case-control studies reported inverse (8)(9)(10)(11)15), associations. Potential recall bias in the case-controls studies may have influenced the study results and contributed to these inconsistent findings.In analyses by NHL subtype, we observed an association between current use of 60þ pills/month of NSAIDs use and increased risk of follicular lymphoma that persisted when NSAID exposure was lagged and was strongest for long-term, regular NSAID users.…”

Section: Discussionmentioning

confidence: 91%

“…However, results of epidemiologic studies of nonsteroidal anti-inflammatory drugs (NSAIDs) in relation to non-Hodgkin lymphoma (NHL) are inconsistent. Positive, negative, and null associations have been reported, with some studies reporting an association with all NSAIDs, whereas others with just aspirin or nonaspirin NSAIDs (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Most studies had limited statistical power, particularly for detailed analyses by frequency, duration, and type of NSAID use, and/or NHL subtype.…”

Section: Introductionmentioning

confidence: 99%

Aspirin and Other Nonsteroidal Anti-Inflammatory Drugs and Risk of Non-Hodgkin Lymphoma

Teras

Gapstur

Patel

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Few large prospective studies have examined associations between nonsteroidal anti-inflammatory drug (NSAID) use and non-Hodgkin lymphoma (NHL). We examined the association between NSAID use and NHL incidence among 149,570 participants in the Cancer Prevention Study-II Nutrition cohort. Aspirin and nonaspirin NSAID use were reported at enrollment in 1992 and updated on periodic follow-up questionnaires. During follow-up through 2007, 1,709 incident NHLs were identified. Time-dependent hazard ratios were calculated using extended Cox regression. Compared to no use, current use of 60þ NSAID pills/month (aspirin and nonaspirin NSAIDs combined) was associated with slightly higher NHL incidence (hazard ratio [HR] ¼ 1.26, 95% confidence interval [CI], 1.04-1.53), but no association with frequency of use was observed when NSAID exposure was lagged by approximately 2 years (HR ¼ 1.08, 95% CI, 0.88-1.32). Long duration regular use (current use of 30þ pills/month for 5 years) was not associated with NHL incidence (HR ¼ 1.09, 95% CI, 0.91-1.33). In subtype analyses, current use of 60þ NSAID pills/month was associated with follicular lymphoma incidence (HR ¼ 1.87, 95% CI, 1.08-3.24). This association persisted when NSAID exposure was lagged (HR ¼ 1.76, 95% CI, 1.04-2.98) and was similar for aspirin and nonaspirin NSAIDs. The association of current, but not lagged, NSAID use with risk of all NHL could be attributable to use of NSAIDs to relieve symptoms of undiagnosed NHL. However, the association with follicular lymphoma persisted in analyses where NSAID use was lagged and should be investigated further. These findings are particularly important for aspirin as the risks and benefits of prophylactic daily use are weighed. Cancer Epidemiol Biomarkers Prev; 22(3);

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“…There was no way to ascertain whether or not those individuals who refused to complete the instrument differed from participants with respect to aspirin use. Nevertheless, previous studies that used the PEDS database and looked at effects of aspirin on variety of cancer sites like ovary, colon, pancreas, breast, nonHodgkin lymphoma and lung 30,32,[68][69][70][71] consistently replicated established epidemiological associations. Moreover, the descriptive characteristics of the subjects (Table I) are consistent with well documented reports in the literature, [10][11][12] suggesting that the results may be generalized to a larger population.…”

Section: Discussionmentioning

confidence: 99%

Regular aspirin use and esophageal cancer risk

Jayaprakash

Menezes

Javle

et al. 2006

Intl Journal of Cancer

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Given the high mortality rate and the rapidly increasing incidence rate of esophageal carcinoma, chemopreventive agents are highly desirable. Aspirin has been shown to be associated with reduced risk of developing colorectal carcinoma and other cancers. Even though previous studies have shown reduced risk of esophageal cancer associated with aspirin use, results were inconsistent with respect to frequency and duration of use. In this hospital-based case-control study, 163 esophageal cancer cases were compared to 482 age-and sex-matched hospital controls with nonneoplastic conditions. Participants were classified as regular aspirin users if they had taken the drug at least once a week for 6 months. Results suggest that esophageal cancer risk is significantly lower for regular aspirin users compared to nonusers [adjusted odds ratio (aOR) 0.54; 95% confidence interval (CI) 0.36-0.86]. Individuals who used an equivalent of at least 1 aspirin a day ( 7 tablets/week) were half as likely to have been diagnosed with esophageal carcinoma (aOR 0.47; 95% CI 0.26-0.85), and a linear trend was noted with increasing frequency of use (p trend 0.007). Similar protective effects were noted with 20 years of use, whereas no risk reduction was noted with >20 years of use. Consistent reduction in risk associated with aspirin use was noted among both the major histological subtypes, but the protective effect appears to be more pronounced in adenocarcinoma compared to squamous cell carcinoma. Overall, results from the current study suggest that regular aspirin use may be associated with reduced risk of esophageal cancer. ' 2006 Wiley-Liss, Inc.Key words: aspirin; esophageal cancer; histology; chemoprevention; epidemiology The American Cancer Society has estimated that 14,520 new cases of esophageal carcinoma will be diagnosed in the United States (US) in 2005. 1 Worldwide, esophageal carcinoma is the 8th most common cancer, responsible for 462,000 new cancer cases in 2002. 2 The 5-year survival rate for esophageal carcinoma was only 14% in US 1 and 10% in Europe, 3 contributing to its position as the cancer with 3rd worse survival rate in the US 1 and as the 6th most deadly cancer throughout the world. 2 There has been a significant increase in the incidence rate of esophageal carcinoma among US males since the 1970s. 4,5 Several other countries have also noted a sharp increases in esophageal carcinoma, and in some regions, the rate has increased more than for any other malignancy. 6,7 Interestingly, the 2 main histological subtypes, squamous cell carcinoma and adenocarcinoma, differ from each other not only by the site of origin, histology, progression and risk factors, [8][9][10][11][12] but also by opposite trends in incidence over last 2 decades. 13-15 While the absolute incidence of squamous cell carcinoma of esophagus fell by one-third, the incidence of adenocarcinoma had a 6-fold increase, which represents the greatest rate of increase among all major malignancies in the US. 16 Thus, in light of increased incidence rates, late...

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Regular use of aspirin or acetaminophen and risk of non-Hodgkin lymphoma

Cited by 32 publications

References 37 publications

Autoimmune Disorders and Lymphomas

Autoimmune Disorders and Lymphomas

Aspirin and Other Nonsteroidal Anti-Inflammatory Drugs and Risk of Non-Hodgkin Lymphoma

Regular aspirin use and esophageal cancer risk

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