Regular use of H2 blockers reduces the efficacy of roxatidine to control gastric pH and volume

Hirota, Kazuyoshi; Kudo, M; Kushikata, Tetsuya; Hashimoto, Hiroshi; Matsuki, Akitomo

doi:10.1007/bf03027723

Cited by 9 publications

(4 citation statements)

References 15 publications

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“…The percentages of inhibition of gastric juice, GJ, 98.1%, 91.1%, 47.5%, 60.2%, 88.3% and 61.2%, respectively for 6a-6f ; GJ, 94.3%, 88.7%, 86.3%, 68.2%, 68.3% and 70.2%, respectively for 8g-8l [3]. As seen, compounds 6a, 6f and 8g exhibited significant gastric acid antisecretory activity.…”

Section: Biological Evaluationmentioning

confidence: 69%

Synthesis of New Phenoxypropylamines and Evaluation of their Antiulcer Activity as H<sub>2</sub> -Receptor Antagonist

Zhang

Tian

et al. 2012

AMR

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Section: Biological Evaluationmentioning

confidence: 69%

Synthesis of New Phenoxypropylamines and Evaluation of their Antiulcer Activity as H<sub>2</sub> -Receptor Antagonist

Zhang

Tian

et al. 2012

AMR

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“…4 A health care provider should oversee GERD treatment so he can give accurate medical information and make the appropriate referrals. Teach her how to increase her dietary calcium.…”

Section: Caring For Your Patientmentioning

confidence: 99%

“…4,6 In the past year, two major research studies have connected PPI use to an increased risk of fractures, especially hip fractures. Histamine 2 -receptor antagonists affect the first step of acid secretion.…”

Section: How Do These Drugs Work?mentioning

confidence: 99%

Bone up on proton pump inhibitors and fracture risk

Gendreau-Webb

2007

Nursing

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“…(5,6) We have previously reported that patients receiving H 2 antagonists for more than 4 weeks show resistance to preanesthetic H 2 antagonist treatment, used for acid aspiration pneumonia prophylaxis. (7) If patients develop tolerance then preanesthetic H 2 antagonist medication would be essentially useless and an alternative would be required. In contrast, PPIs may be a suitable alternative as they produce a similar or more potent anti-secretory effect on gastric acid secretion than H 2 antagonists.…”

Section: Introductionmentioning

confidence: 99%

A marked increase in gastric fluid volume during cardiopulmonary bypass

Hirota

Kudo

Hashimoto

et al. 2011

J. Clin. Biochem. Nutr.

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Major physiological stress occurs during cardiac surgery with cardiopulmonary bypass. This is related to hypothermia and artificial organ perfusion. Thus, serious gastrointestinal complications, particularly upper gastrointestinal bleeding, sometimes follow cardiac surgery. We have compared the antisecretory effects of a preanesthetic H2 antagonist (roxatidine, cardiopulmonary bypass-H2 group, n = 15) and a proton pump inhibitor (rabeprazole, cardiopulmonary bypass-PPI group, n = 15) in patients undergoing cardiac surgery with cardiopulmonary bypass, and also compared in patients undergoing a off-pump coronary artery bypass graft surgery (off-pump cardiopulmonary bypass-H2 group, n = 15). Gastric pH (5.14 ± 0.61) and gastric fluid volume (13.2 ± 2.4 mL) at the end of surgery in off-pump cardiopulmonary bypass-H2 groups was significantly lower and higher than those in both cardiopulmonary bypass-H2 (6.25 ± 0.54, 51.3 ± 8.0 mL) and cardiopulmonary bypass-PPI (7.29 ± 0.13, 63.5 ± 14.8 mL) groups, respectively although those variables did not differ between groups after the induction of anesthesia. Plasma gastrin (142 ± 7 pg/mL) at the end of surgery and maximal blood lactate levels (1.50 ± 0.61 mM) in off-pump cardiopulmonary bypass-H2 group were also significantly lower than those in both cardiopulmonary bypass-H2 (455 ± 96 pg/mL, 3.97 ± 0.80 mM) and cardiopulmonary bypass-PPI (525 ± 27 pg/mL, 3.15 ± 0.44 mM) groups, respectively. In addition, there was a significant correlation between gastric fluid volume and maximal blood lactate (r = 0.596). In conclusion, cardiopulmonary bypass may cause an increase in gastric fluid volume which neither H2 antagonist nor PPI suppresses. A significant correlation between gastric fluid volume and maximal blood lactate suggests that gastric fluid volume may predict degree of gastrointestinal tract hypoperfusion.

show abstract

Regular use of H2 blockers reduces the efficacy of roxatidine to control gastric pH and volume

Cited by 9 publications

References 15 publications

Synthesis of New Phenoxypropylamines and Evaluation of their Antiulcer Activity as H<sub>2</sub> -Receptor Antagonist

Synthesis of New Phenoxypropylamines and Evaluation of their Antiulcer Activity as H<sub>2</sub> -Receptor Antagonist

Bone up on proton pump inhibitors and fracture risk

A marked increase in gastric fluid volume during cardiopulmonary bypass

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