Regularities of Multicomponent Transport in Polymer Systems for Controlled Drug Release

Polishchuk, A. Ya.; Zimina, L. A.; Madyuskin, N. N.; Заиков, Г. Е.; Petropoulos, J. H.

doi:10.1080/00914039608029382

Cited by 20 publications

(27 citation statements)

References 5 publications

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“…With increase in the immersion time, more and more PBS buffer penetrates into the composite microspheres, accompanying the swelling. This leads to hydrolysis of covalent bonds in the, PLGA polymer and further, results in bulk erosion of the PLGA polymer 17. Figure 4(b) shows the microstructure of a composite microsphere with 10 wt % xerogel loading after being immersed in PBS buffer for 19 days.…”

Section: Resultsmentioning

confidence: 99%

Biodegradable polymer–silica xerogel composite microspheres for controlled release of gentamicin

Xue¹,

Tan²,

Lukito³

2006

J Biomed Mater Res

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Single and double layered composite microspheres were prepared by encapsulating gentamicin-loaded silica xerogels with biodegradable PLGA polymers (poly(DL-lactide-co-glycolide)). The in vitro drug release properties of both the composite microspheres were investigated. The single layered composite microspheres showed a high initial burst, followed by two sustained release stages lasting for approximately 6 weeks. The two sustained release stages of the single layered composite microspheres could be attributed to the swelling and bulk erosion of the polymer encapsulations, respectively. In comparison with the single layered composite microspheres, the double layered composite microspheres realized a much reduced initial burst together with three sustained release stages. The whole release period of the double layered composite microspheres could last more than 9 weeks. These distinct behaviors make the double layered composite microspheres promising as a new drug release material for localized drug delivery applications.

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Section: Resultsmentioning

confidence: 99%

Biodegradable polymer–silica xerogel composite microspheres for controlled release of gentamicin

Xue¹,

Tan²,

Lukito³

2006

J Biomed Mater Res

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“…This feature of the water diffusion coefficient is reported as typical for cellulose derivatives. 44,45 Information on the interaction of water with cellulose ester membranes has also come from NMR spectral 46 and relaxation time 47 measurements, and shows the presence of both polymer-bound and bulk water. Diffusion coefficients of SDS were measured in the polymer membranes at 25 and 40°C.…”

Section: Methodsmentioning

confidence: 99%

Transport Properties of Concentrated Aqueous Sodium Dodecyl Sulfate Solutions in Polymer Membranes Derived from Cellulose Esters

2000

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Polymer membranes with differing degrees of hydrophilicity were prepared from mixtures of cellulose acetate butyrate and cellulose acetate hydrogen phthalate. The degree of hydrophilicity was determined from measurements of water uptake and the apparent water diffusion coefficient. The transport properties of sodium dodecyl sulfate through these membranes were studied by measuring permeability using the time-lag technique. The mutual differential diffusion coefficients of the surfactant are 1-2 orders of magnitude lower than in aqueous solution. The permeability and partition coefficients between the aqueous subphase and membranes were found to depend on the hydrophilicity of the polymer blend, but to be virtually independent of temperature. Possible applications of these systems in surfactant purification are suggested.

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“…The resulting sustained release profile yields kinetics that fall between zero and first order (Figure ). in vitro release kinetics, insensitivity to membrane thickness, and nanometer scale of the rate limiting pore‐size suggest aflibercept transport across these membranes was dominated by Knudsen diffusion …”

Section: Resultsmentioning

confidence: 99%

“…in vitro release kinetics, insensitivity to membrane thickness, and nanometer scale of the rate limiting pore-size suggest aflibercept transport across these membranes was dominated by Knudsen diffusion. 15,16 To construct devices, a combination of microporous PCL (mpPCL) and nonporous PCL (npPCL) films were used. Rather than altering membrane properties to tune release rates, mpPCL membrane area was adjusted to provide desired release rates.…”

Section: Introductionmentioning

confidence: 99%

Device design methodology and formulation of a protein therapeutic for sustained release intraocular delivery

Schlesinger

Bernards

Chen

et al. 2018

Bioengineering & Transla Med

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Despite years of effort, sustained delivery of protein therapeutics remains an unmet need due to three primary challenges – dose, duration, and stability. The work presented here provides a design methodology for polycaprolactone reservoir‐based thin film devices suitable for long‐acting protein delivery to the back of the eye. First, the challenge of formulating highly concentrated protein in a device reservoir was addressed by improving stability with solubility‐reducing excipients. Next, predictive correlations between design parameters and device performance were developed to provide a methodology to achieve a target product profile. Prototype devices were designed using this methodology to achieve desired device size, release rate, therapeutic payload, and protein stability, assessed by in vitro studies. Finally, prototype tolerability was established in a non‐human primate model. The design methodology presented here is widely applicable to reservoir‐based sustained delivery devices for proteins and provides a general device design framework.

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Regularities of Multicomponent Transport in Polymer Systems for Controlled Drug Release

Cited by 20 publications

References 5 publications

Biodegradable polymer–silica xerogel composite microspheres for controlled release of gentamicin

Biodegradable polymer–silica xerogel composite microspheres for controlled release of gentamicin

Transport Properties of Concentrated Aqueous Sodium Dodecyl Sulfate Solutions in Polymer Membranes Derived from Cellulose Esters

Device design methodology and formulation of a protein therapeutic for sustained release intraocular delivery

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