In recent years, two different multigraded variants of Castelnuovo-Mumford regularity have been developed, namely multigraded regularity, defined by the vanishing of multigraded pieces of local cohomology modules, and the resolution regularity vector, defined by the multi-degrees in a minimal free resolution. In this paper, we study the relationship between multigraded regularity and the resolution regularity vector. Our method is to investigate multigraded variants of the usual a * -invariant. This, in particular, provides an effective approach to examining the vanishing of multigraded pieces of local cohomology modules with respect to different multigraded ideals.