As time goes by, the development of technology and the internet is increasingly rapid in the midst of the Industry 5.0 era, accompanied by the digitalization of banking, which has a positive impact on industry players, but negative impacts also appear to be felt by MSME players. The change in system and culture requires them to re-adapt to these conditions. This research aims to analyze the relationship between the amount of electronic money in circulation, the number of fintech players, and the number of peer-to-peer lending bank accounts and their influence on MSME financing in Indonesia in the industrial era 5.0. This research adopts a quantitative approach, analyzing secondary time series data from January 2018 to August 2023. This study reveals a positive and significant impact of both electronic money circulation and peer-to-peer lending accounts on MSME financing. This suggests that higher levels of e-money and peer-to-peer lending accounts potentially promote MSME growth in industry 5.0. However, the number of fintech players did not exhibit a significant influence, indicating its lack of association with MSME development in this context.