Regulated Expression of Galectin-1 after<i>In Vitro</i>Productive Infection with Herpes Simplex Virus Type I: Implications for T Cell Apoptosis

González, Manuel Machuca; Rubinstein, Natalia; Ilarregui, Juan M.; Toscano, Marta A.; Sanjuán, Norberto; Rabinovich, Gabriel A.

doi:10.1177/039463200501800402

Cited by 25 publications

(17 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…experimental removal of the Nipah virus N glycans resulted in higher fusogenicity, but also increased sensitivity to neutralization by specific antisera, suggesting that although the viral glycans can hinder viral infectivity to some extent, they serve a protective function against the neutralizing host antibodies 74 . Modulatory effects of viral infection (for example, by herpesvirus 1, Newcastle disease and epstein–Barr virus) 75–77 on galectin expression and function suggest that galectins participate at various levels of antiviral defence, from the initial recognition and blocking of envelope and fusion glycoproteins, to the activation and amplification of the innate and adaptive immune responses.…”

Section: Galectins As Prrsmentioning

confidence: 99%

Roles of galectins in infection

2009

View full text Add to dashboard Cite

Galectins, which were first characterized in the mid-1970s, were assigned a role in the recognition of endogenous (‘self) carbohydrate ligands in embryogenesis, development and immune regulation. Recently, however, galectins have been shown to bind glycans on the surface of potentially pathogenic microorganisms, and function as recognition and effector factors in innate immunity. Some parasites subvert the recognition roles of the vector or host galectins to ensure successful attachment or invasion. This Review discusses the role of galectins in microbial infection, with particular emphasis on adaptations of pathogens to evasion or subversion of host galectin-mediated immune responses.

show abstract

Section: Galectins As Prrsmentioning

confidence: 99%

Roles of galectins in infection

2009

View full text Add to dashboard Cite

show abstract

“…Through cross‐linking specific glycoconjugates and forming ordered lattices on the T‐cell surface, galectin‐1 can regulate the viability of different T‐cell subsets, particularly those imprinted with a “pro‐inflammatory signature,” which are endowed with a distinct glycosylation profile 62,65,68,71–85 …”

Section: Functions Of Galectins In Immune Cells Demonstrated In Vitromentioning

confidence: 99%

Galectins: regulators of acute and chronic inflammation

Liu

Rabinovich

2010

Annals of the New York Academy of Sciences

367

317

View full text Add to dashboard Cite

Galectins, beta-galactoside-binding animal lectins, are differentially expressed by various immune cells as well as a wide range of other cell types. Extracellularly, galectins are able to exhibit bivalent or multivalent interactions with cell-surface glycans on various immune cells and exert various effects. These include cytokine and mediator production, cell adhesion, apoptosis, and chemoattraction. In addition, they can form lattices with cell-surface glycoprotein receptors, resulting in modulation of receptor functions, including clustering and endocytosis. Intracellularly, galectins can participate in signaling pathways and modulate biologic responses. These include apoptosis, cell differentiation, and cell migration. Thus, a large body of literature indicates that galectins play important roles in the immune and inflammatory responses through regulating the homeostasis and functions of immune cells. The use of mice deficient in individual galectins has provided additional evidence for the contributions of these proteins to these responses. Current research indicates that galectins play important roles in the development of acute inflammation as well as chronic inflammation associated with allergies, autoimmune diseases, atherosclerosis, infectious processes, and cancer. Thus, recombinant proteins or specific galectin inhibitors may be used as therapeutic agents for inflammatory diseases.

show abstract

“…Considerable evidence has been accumulating regarding the role of galectin‐1 in the control of T‐cell viability along the whole lifespan of T cells from developing thymocytes to activated and fully‐differentiated effector T cells (28, 31, 34, 62–79) (). T‐cell susceptibility to galectin‐1‐induced cell death may be regulated at least at three distinct levels.…”

Section: Regulatory Checkpoints Targeted By Galectin‐1 During the Lifmentioning

confidence: 99%

Conveying glycan information into T‐cell homeostatic programs: a challenging role for galectin‐1 in inflammatory and tumor microenvironments

Rabinovich

Ilarregui

2009

Immunological Reviews

View full text Add to dashboard Cite

The immune system has evolved sophisticated mechanisms composed of several checkpoints and fail-safe processes that enable it to orchestrate innate and adaptive immunity, while at the same time limiting aberrant or unfaithful T-cell function. These multiple regulatory pathways take place during the entire life-span of T cells including T-cell development, homing, activation, and differentiation. Galectin-1, an endogenous glycan-binding protein widely expressed at sites of inflammation and tumor growth, controls a diversity of immune cell processes, acting either extracellularly through specific binding to cell surface glycan structures or intracellularly through modulation of pathways that remain largely unexplored. In this review, we highlight the discoveries that have led to our current understanding of the role of galectin-1 in distinct immune cell process, particularly those associated with T-cell homeostasis. Also, we emphasize findings emerging from the study of experimental models of autoimmunity, chronic inflammation, fetomaternal tolerance, and tumor growth, which have provided fundamental insights into the critical role of galectin-1 and its specific saccharide ligands in immunoregulation. Challenges for the future will embrace the rational manipulation of galectin-1-glycan interactions both towards attenuating immune responses in autoimmune diseases, graft rejection, and recurrent fetal loss, while at the same overcoming immune tolerance in chronic infections and cancer.

show abstract

Regulated Expression of Galectin-1 afterIn VitroProductive Infection with Herpes Simplex Virus Type I: Implications for T Cell Apoptosis

Cited by 25 publications

References 42 publications

Roles of galectins in infection

Roles of galectins in infection

Galectins: regulators of acute and chronic inflammation

Conveying glycan information into T‐cell homeostatic programs: a challenging role for galectin‐1 in inflammatory and tumor microenvironments

Contact Info

Product

Resources

About