In 2008, the world was introduced to Blockchain. In 2009, the first open-source Blockchainbased cyber currency was introduced as Bitcoin. By 2025, studies indicate that Blockchain-based enterprise-wide application revenue will reach nearly $20 billion. Therefore, this study proposes to build on the success of Thailand's National Single Window (THAINSW) gateway document interchange architecture (DIA) and further expand its availability to a much larger network of e-Government participants using Blockchain architecture. Therefore, the authors set how to investigate how and where Blockchain technology could be implemented in order to support of Thailand's 4.0 and digital economy visions. In addition to the qualitative analysis of the literature, the authors used input from a panel of 25 Thai experts to develop a foundation for the analysis based on Sathosi Nakamoto’s seven Blockchain disciplines. This analysis was enhanced from the authors’ own experiences in real-world Blockchain implementations. Results revealed that Blockchain is a highly innovative approach to secure transaction execution, information storage, performing functions, and establishing trust in an open architectural environment.Blockchain has the potential to increase good governance, increase transparency and privacy, and reduce the chance of corruption.