Regulating distal tip cell migration in space and time

Cecchetelli, Alyssa D.; Cram, Erin J.

doi:10.1016/j.mod.2017.04.003

Cited by 18 publications

(8 citation statements)

References 86 publications

(105 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over-expression of the C. elegans RhoU/RhoV ortholog CHW-1 disrupted migration of gonadal distal tip cells, 27 a well-characterized migration model in C. elegans. 31 In addition, RhoU is required for the migration of cranial neural crest cells in Xenopus laevis embryos. 32 RhoU also regulates the ability of these cells to differentiate into craniofacial cartilages.…”

Section: In Vivo Studiesmentioning

confidence: 99%

Regulation and functions of RhoU and RhoV

Hodge

Ridley

2017

Small GTPases

View full text Add to dashboard Cite

Rho GTPases play central roles in a wide variety of cellular processes, including cytoskeletal dynamics, cell adhesion and cell polarity. RhoU and RhoV are Rho GTPases that have some atypical properties compared with classical Rho family members, such as the presence of N-and C-terminal extension regions, unusual GDP/GTP cycling and post-translational modification by palmitoylation but not prenylation. Their activity and localization is regulated by the N-terminal and C-terminal regions, and so far no GEFs or GAPs have been identified for them. Similar to Rac and Cdc42, they interact with PAK serine/threonine kinases, and in the case of PAK4, this interaction leads to RhoU protein stabilization. In cells, RhoU and RhoV alter cell shape and cell adhesion, which probably underlies some of the phenotypes reported for these proteins in vivo, for example in heart development and epithelial morphogenesis. However, the molecular basis for these functions of RhoU and RhoV remains to be characterized.

show abstract

Section: In Vivo Studiesmentioning

confidence: 99%

Regulation and functions of RhoU and RhoV

Hodge

Ridley

2017

Small GTPases

View full text Add to dashboard Cite

show abstract

“…Migration ceases at the end of the L4 larval stage. The process of DTC migration has been extensively genetically dissected, and this work has been reviewed elsewhere recently [ 23 , 24 , 25 ].…”

Section: Resultsmentioning

confidence: 99%

Recent Advances in the Genetic, Anatomical, and Environmental Regulation of the C. elegans Germ Line Progenitor Zone

Gordon

2020

JDB

View full text Add to dashboard Cite

The C. elegans germ line and its gonadal support cells are well studied from a developmental genetics standpoint and have revealed many foundational principles of stem cell niche biology. Among these are the observations that a niche-like cell supports a self-renewing stem cell population with multipotential, differentiating daughter cells. While genetic features that distinguish stem-like cells from their differentiating progeny have been defined, the mechanisms that structure these populations in the germ line have yet to be explained. The spatial restriction of Notch activation has emerged as an important genetic principle acting in the distal germ line. Synthesizing recent findings, I present a model in which the germ stem cell population of the C. elegans adult hermaphrodite can be recognized as two distinct anatomical and genetic populations. This review describes the recent progress that has been made in characterizing the undifferentiated germ cells and gonad anatomy, and presents open questions in the field and new directions for research to pursue.

show abstract

“…Increased expression of UNC-5 in the distal tip cells is required for the ventral-to-dorsal turn of the distal tip cells (53). Heterochronic genes allow UNC-5 to be expressed at the proper time to drive distal tip cell migrations (54). Similarly, during the development of the nervous system, the UNC-5 receptor is expressed and localized to particular segments of developing neurites and it is transcriptionally controlled as neurons turn dorsally (48).…”

Section: Discussionmentioning

confidence: 99%

Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes

Armakola

Ruvkun

2019

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Many neurons display characteristic patterns of synaptic connections that are under genetic control. The Caenorhabditis elegans DA cholinergic motor neurons form synaptic connections only on their dorsal axons. We explored the genetic pathways that specify this polarity by screening for gene inactivations and mutations that disrupt this normal polarity of a DA motorneuron. A RAB-3::GFP fusion protein that is normally localized to presynaptic terminals along the dorsal axon of the DA9 motorneuron was used to screen for gene inactivations that disrupt the DA9 motorneuron polarity. This screen identified heterochronic genes as major regulators of DA neuron presynaptic polarity. In many heterochronic mutants, presynapses of this cholinergic motoneuron are mislocalized to the dendrite at the ventral side: inactivation of the blmp-1 transcription factor gene, the lin-29/Zn finger transcription factor, lin-28/RNA binding protein, and the let-7miRNA gene all disrupt the presynaptic polarity of this DA cholinergic neuron. We also show that the dre-1/F box heterochronic gene functions early in development to control maintenance of polarity at later stages, and that a mutation in the let-7 heterochronic miRNA gene causes dendritic misplacement of RAB-3 presynaptic markers that colocalize with muscle postsynaptic terminals ectopically. We propose that heterochronic genes are components in the UNC-6/Netrin pathway of synaptic polarity of these neurons. These findings highlight the role of heterochronic genes in postmitotic neuronal patterning events.

show abstract

Regulating distal tip cell migration in space and time

Cited by 18 publications

References 86 publications

Regulation and functions of RhoU and RhoV

Regulation and functions of RhoU and RhoV

Recent Advances in the Genetic, Anatomical, and Environmental Regulation of the C. elegans Germ Line Progenitor Zone

Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes

Contact Info

Product

Resources

About