Regulating effect of<i>Lactobacillus plantarum</i>CQPC03 on lipid metabolism in high‐fat diet‐induced obesity in mice

Gan, Yi; Chen, Hong; Zhou, Xianrong; Chu, Lingling; Ran, Wan-Ting; Tan, Fang

doi:10.1111/jfbc.13495

Cited by 10 publications

(9 citation statements)

References 47 publications

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“…Proliferator-activated receptors with three subtypes are widely recognized as ligand-induced nuclear receptors that are responsible for various biological effects. Among these subtypes, PPAR-α is highly expressed in liver tissues, is closely related to lipid metabolism (fatty acid β-oxidation), and participates in the respiratory chain of oxidation ( 38 , 39 ). The magnitude of change in PPAR- α expression is related to the amount of damage incurred by the liver.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Lactobacillus plantarum HFY09 on Ethanol-Induced Liver Injury in Mice

et al. 2021

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Lactobacillus plantarum is a bacterial strain that is used as a probiotic with health-promoting effects. Our study investigated the hepatoprotective effect of Lactobacillus plantarum HFY09 (LP-HFY09) in mice with ethanol-induced liver injury. The protection afforded by LP-HFY09 was evaluated by observing the morphology of hepatic tissue and measuring liver lipid indexes and function indexes, levels of anti-oxidative enzymes, and anti-inebriation enzymes, as well as oxidative metabolism-related gene expression. Gavage administration of LP-HFY09 [1 × 109 CFU/kg body weight (bw)] limited the loss of bw, alcohol damage to the liver, and maintained the normal hepatic tissue morphology. Lactobacillus plantarum HFY09 intervention in ethanol-induced mice led to decreases in serum triglyceride (TG), total cholesterol (TC), aspartic transaminase, alanine transaminase, hyaluronidase (HAase), and precollagen III (PC III), and increases in liver alcohol dehydrogenase (ADH), and acetaldehyde dehydrogenase (ALDH). Lactobacillus plantarum HFY09 assisted with alleviating inflammation by elevating the level of interleukin 10 (IL-10) and decreasing the levels of pro-inflammatory factors [IL-6, IL-1β, and tumor necrosis factor-α (TNF)-α]. Lactobacillus plantarum HFY09 significantly elevated hepatic levels of superoxide dismutase (SOD) and glutathione (GSH), and decreased liver malondialdehyde (MDA) from 3.45 to 1.64 nmol/mg protein. Lactobacillus plantarum HFY09 exhibited an overall strong regulatory effect on liver protection when compared to that of commercial Lactobacillus delbrueckii subsp. bulgaricus. The hepatoprotective effect of LP-HFY09 was reflected by the upregulated expression of peroxisome proliferator activated-receptors α, SOD1, SOD2, glutathione peroxidase (GSH-Px), nicotinamide adenine dinucleotide phosphate (NADPH), and catalase (CAT), and the downregulated expression of cyclooxygenase-1 (COX1), c-Jun N-terminal kinase (JNK), and extracellular regulated protein kinases (ERK). Administration of LP-HFY09 at a concentration of 1.0 × 109 CFU/kg bw could be a potential intervention, for people who frequently consume alcohol.

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Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Lactobacillus plantarum HFY09 on Ethanol-Induced Liver Injury in Mice

et al. 2021

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“…Liver tissues were sliced after being embedded in the paraffin and then stained with H&E (Gan, Chen, et al, 2020;Gan, Liang, et al, 2020). The morphological differences of hepatic tissues were observed by optical microscopy.…”

Section: Hepatic Morphologymentioning

confidence: 99%

Protective effect of Lactiplantibacillus pentosus CQZC01 in Kunming mice of subacute alcoholic liver injury

Gan

Peng

Zhang

et al. 2023

Journal of Food Science

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To decrease the climbing rate of alcoholic liver disease, the protective effect in subacute alcoholic liver injury of newly isolated Lactiplantibacillus pentosus CQZC01 has been investigated. Lactiplantibacillus pentosus CQZC01 (1 × 109 CFU/kgbw) administered orally could keep weight of mice at 30.54 ± 1.15 g; alleviate alcoholic damage on hepatic morphology; decrease the activities of hyaluronidase (147 ± 19 U/L), procollagen III (4.82 ± 0.54 ng/mL), alanine transaminase (10.66 ± 2.32 U/L), and aspartate aminotransferase (15.18 ± 1.98 U/L); enhance the activities of alcohol dehydrogenase (65.15 ± 3.2 U/mgprot), aldehyde dehydrogenase (16.50 ± 0.96 U/mgprot), superoxide dismutase (623 ± 39 U/mgprot), and glutathione (19.54 ± 2.46 µmol/gprot); and decrease liver total cholesterol (3.59 ± 0.50 mmol/gprot) and triglyceride (0.88 ± 0.24 mmol/gprot) (p < 0.05). Moreover, L. pentosus CQZC01 elevated the level of interleukin‐10 (IL‐10; 807 ± 44 pg/mL) but significantly decreased the levels of IL‐1β (29.75 ± 5.27pg/mL), IL‐6 (58 ± 8 pg/mL), and tumor necrosis factor‐α (TNF‐α, 564 ± 13 pg/mL). Liver malondialdehyde was also significantly decreased by treatment with L. pentosus CQZC01 from 3.61 ± 0.14 to 2.03 ± 0.49 nmol/mgprot. The relative expression of C‐Jun N‐terminal kinase, extracellular regulated protein kinases, and cyclooxygenase‐1 was downregulated, and the SOD1, SOD2, peroxisome proliferator‐activated receptor‐α, glutathione peroxidase, catalase, nuclear factor erythroid‐2‐related factor 2, heme oxygenase‐1 and nicotinamide adenine dinucleotide phosphate were upregulated by L. pentosus CQZC01. The overall protective effect of L. pentosus CQZC01 was comparable to commercial Lactobacillus delbrueckii subsp. Bulgaricus. Lactobacillus pentosus CQZC01 might be a suitable hepatoprotective measure for people who frequently ingest alcoholic drinks. Practical Application L. pentosus CQZC01 can alleviate subacute alcoholic liver injury by raising the antioxidant status and upregulating the antioxidant‐related genes.

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“…Treatment with L. plantarum CQPC03 restored liver function and oxidative stress in mice and reduced fat accumulation in the liver. In addition to regulating lipid metabolism in the liver, it also alleviates inflammation by increasing the levels of interleukins IL-10 and IL-4, and decreasing the levels of proinflammatory factors, including IL-6, IL-1β, TNF-α, and IFN-γ [77]. Additionally, endotoxin levels and proinflammatory cytokines were significantly reduced, and the microbiota was controlled in the colon [78].…”

Section: Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

The Lactobacillus as a Probiotic: Focusing on Liver Diseases

Jeong¹,

Park²,

Gi³

et al. 2022

Microorganisms

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Over the past decade, scientific evidence for the properties, functions, and beneficial effects of probiotics for humans has continued to accumulate. Interest in the use of probiotics for humans has increased tremendously. Among various microorganisms, probiotics using bacteria have been widely studied and commercialized, and, among them, Lactobacillus is representative. This genus contains about 300 species of bacteria (recently differentiated into 23 genera) and countless strains have been reported. They improved a wide range of diseases including liver disease, gastrointestinal diseases, respiratory diseases, and autoimmune diseases. Here, we intend to discuss in depth the genus Lactobacillus as a representative probiotic for chronic liver diseases.

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Regulating effect ofLactobacillus plantarumCQPC03 on lipid metabolism in high‐fat diet‐induced obesity in mice

Cited by 10 publications

References 47 publications

Hepatoprotective Effect of Lactobacillus plantarum HFY09 on Ethanol-Induced Liver Injury in Mice

Hepatoprotective Effect of Lactobacillus plantarum HFY09 on Ethanol-Induced Liver Injury in Mice

Protective effect of Lactiplantibacillus pentosus CQZC01 in Kunming mice of subacute alcoholic liver injury

The Lactobacillus as a Probiotic: Focusing on Liver Diseases

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