Regulation and role of notch signaling in epithelial progenitor cell differentiation and proliferation in the normal and the fibrotic lung

Piskulak, K; Henneke, I; Wilhelm, Joshua J.; Bellusci, Saverio; Seeger, Werner; Günther, Andreas; Ruppert, Clemens

doi:10.1055/s-0032-1315514

Cited by 1 publication

(1 citation statement)

References 77 publications

(93 reference statements)

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“…Differential regulation of transforming growth factor-a, the Wnt protein signalling pathway and the cell signalling Notch pathway was recently identified by transcriptome profiling of normal appearing, microdissected alveolar septae from IPF lungs [84]. PISKULAK et al [85] showed that there were no significant changes in the expression of Notch receptors and ligands on mRNA level in lung homogenates of organ donors and IPF patients. At the protein level, however, the receptor Notch1 (NICD1) and the Notch ligand Delta1 were found to be up-regulated in lungs of IPF patients and bleomycin-challenged mice.…”

Section: Idiopathic Pulmonary Fibrosismentioning

confidence: 99%

Clinical highlights from the 2013 ERS Congress in Barcelona

Spruit¹,

Marvisi

Coolen³

et al. 2014

Eur Respir J

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This article reviews a selection of scientific presentations in the area of clinical problems, which were presented at the 2013 European Respiratory Society Annual Congress in Barcelona, Spain. This article discusses the most relevant topics of interest in the field of clinical respiratory medicine, including breakthrough reports and studies of particular interest to the healthcare professionals. Topics are presented and discussed in the context of the most up-to-date literature, including basic science and translational research. In particular, the reviewed topics deal with the areas of complex chronic obstructive pulmonary disease and asthma (even in the primary care setting), idiopathic pulmonary fibrosis (pathogenesis and therapy), advances in functional chest imaging, interventional pulmonology, pulmonary rehabilitation and chronic care.

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Section: Idiopathic Pulmonary Fibrosismentioning

confidence: 99%