Regulation and therapeutic potentials of microRNAs to non-small cell lung cancer

The interaction between lncRNAs and transcription factors regulating autophagy in human cancers: A comprehensive and therapeutical survey

“…The suppression of MYC/miR‐150 expression significantly prevented in vitro and in vivo cellular proliferation in NSCLC. In cells overexpressing miR‐150, an impairment in the function of autophagic flux was detected, which was correlated with failure in autophagosomes and lysosomes fusion through directly blocking Ectopic P‐Granules 5 Autophagy Tethering Factor (EPG5), as gene vital for autophagosomal maturation 69,70 …”

“…The suppression of MYC/miR-150 expression significantly prevented in vitro and in vivo cellular proliferation in NSCLC. In cells overexpressing miR-150, an impairment in the function of autophagic flux was detected, which was correlated with failure in autophagosomes and lysosomes fusion through directly blocking Ectopic P-Granules 5 Autophagy Tethering Factor (EPG5), as gene vital for autophagosomal maturation 69,70. MYC overexpression leads to miR-150 upregulation, which targets EPG5 and induces DNA damage responses, ER stress, and ROS production mediated by autophagy dysfunction, stimulating the development of NSCLC 69.…”

MiRNAs and Microbiota in Non-Small Cell Lung Cancer (NSCLC): Implications in Pathogenesis and Potential Role in Predicting Response to ICI Treatment

“…The retinoblastoma (RB) pathway is key to regulating cell cycle and cell death through the modulation of several intracellular signaling pathways such as cyclin (CCD), cyclin-dependent kinase (CDK), and E2F-family transcription factors [ 16 ]. The RB signaling pathway can be inhibited in cancers through three processes: decreased RB protein function, increased CDK expression, and decreased expression of CDK inhibitors [ 17 ]. Inhibition of these oncogenic proteins such as CCN, CDK, and E2F1/3 in tumor cells thus represents a potential novel approach for the treatment of NSCLC [ 16 ].…”

“…The PI3K pathway also plays a key role in the pathogenesis of neoplasms as it can modulate several biological mechanisms of cancer cells such as tumor proliferation, growth, and survival [ 17 ]. The dysregulation of this signaling pathway can induce oncogenic effects correlated with the development of several human cancer types, including lung cancer (through enhanced cell proliferation), metastasis, angiogenesis, epithelial-to-mesenchymal transition (EMT), chemoresistance, and apoptosis [ 17 ]. There are several miRNAs that can modulate the PI3K signaling pathway, thus regulating lung cancer development.…”

“…The RTK/RAS/MAPK signaling pathway is another important intracellular oncogenic signaling pathway. It can modulate several cellular processes such as cell proliferation, migration, and apoptosis through the activation of other correlated signaling pathways such as the Janus kinase/signal transducer and activator of transcription (JAK/STAT), mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK), and rat sarcoma virus/rapidly accelerated fibrosarcoma pathways (RAS/RAF) [ 17 ].…”