Regulation Effect of a Chinese Herbal Formula on Flora and Mucosal Immune Secretory Immunoglobulin A in Rats

Liu, Tianhao; Zhang, Xiaomei; Han, Ning; Liu, Yang; Wu, Yueying; Li, Xiaoya; Yang, Zhongshan; Yuan, Jiali

doi:10.1155/2018/4821821

Cited by 11 publications

(9 citation statements)

References 26 publications

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“…Furthermore, increased intestinal sIgA secretion was reported to result from the influence of consuming phenolic- and triterpenoid-rich herbs or medicinal fungus. Liu et al. (2018) showed that Chinese herbal formula Fei-Xi-Tiao-Zhi-Fang significantly upregulated intestinal sIgA concentration, while Cordyceps militaris also showed to increase the ileal sIgA level in E. coli (ATCC 25922)-infected mice ( Zhang et al., 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Laetiporus sulphureus–fermented wheat bran enhanced the broiler growth performance by improving the intestinal microflora and inflammation status

Lin

Lee

2020

Poultry Science

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This study investigates the effects of Laetiporus sulphureus –fermented wheat bran ( LS ) as a feed supplementation on the immunomodulative properties in broiler chickens. Crude phenolic compounds, crude polysaccharides, crude triterpenoids, and ergosterol were determined in LS water extracts. In animal experiments, 400 male broilers (Ross 308) were randomly assigned into 5 groups fed with a corn–soybean–based diet (control) and a control diet replaced with 5% wheat bran ( WB ), 10% WB, 5% LS, and 10% LS, respectively. Each group had 4 replicates and 20 birds per pen (total of 80 birds/treatment). The results showed that the 5% LS–supplemented group had significantly higher BW in the finisher phase (22–35 D). Better feed conversion ratio ( P < 0.05) of LS-supplemented groups was observed in both the finisher phase and the overall experimental period. The LS-supplemented groups had significantly lower coliform counts in the ileum than the other treatment and control groups ( P < 0.05). The results of serum immunoglobulin showed that LS supplementation significantly increased serum IgA concentration compared with the control and WB-supplemented groups ( P < 0.05). Simultaneously, ileal IgA contents of the LS groups were significantly higher than in the WB and control groups ( P < 0.05). Regarding proinflammatory cytokines, serum tumor necrosis factor alpha and IL-6 in the LS-supplemented groups were significantly lower than those in the 10% WB group ( P < 0.05), whereas serum tumor necrosis factor alpha and IL-1β in the 5% LS group were significantly lower than in both the control and WB-supplemented groups ( P < 0.05). An investigation on the effects of LS on immune-related genes in broiler showed that chickens supplemented with 5% LS had lower levels of liver and jejunum IL-1β and NF-κB mRNA compared with the control group and WB groups ( P < 0.05). In conclusion, LS supplementation can potentially enhance growth performance of broilers by improving intestinal microflora and inflammation status.

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Section: Discussionmentioning

confidence: 99%

Laetiporus sulphureus–fermented wheat bran enhanced the broiler growth performance by improving the intestinal microflora and inflammation status

Lin

Lee

2020

Poultry Science

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“…At present, there is no common criterion to judge the balance of lung bacteria. Previously, we used TCM to interfere with flora and immune disorder in model rats, and found that the balance in lung and intestine bacteria of model rats was improved [57].…”

Section: Discussionmentioning

confidence: 99%

Bacterial association and comparison between lung and intestine in rats

et al. 2020

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The association between lung and intestine has already been reported, but the differences in community structures or functions between lung and intestine bacteria yet need to explore. To explore the differences in community structures or functions, the lung tissues and fecal contents in rats were collected and analyzed through 16S rRNA sequencing. It was found that intestine bacteria was more abundant and diverse than lung bacteria. In intestine bacteria, Firmicutes and Bacteroides were identified as major phyla while Lactobacillus was among the most abundant genus. However, in lung the major identified phylum was Proteobacteria and genus Pseudomonas was most prominent genus. On the other hand, in contrast the lung bacteria was more concentrated in cytoskeleton and function in energy production and conversion. While, intestine bacteria were enriched in RNA processing, modification chromatin structure, dynamics and amino acid metabolism. The study provides the basis for understanding the relationships between lung and intestine bacteria.

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“…Gut bacteria play an important role in the digestion and absorption of nutrients in food and are considered as therapeutic targets of many diseases and drugs (30,31). It has become a hot research method in modern pharmacology to study the molecular mechanisms of drug treating diseases by focusing on gut bacteria (20,21). In order to further verify the potential mechanisms of VK2 for salt-sensitive hypertension, we supplemented VK2 to intervene high-salt induced mice, and detected the characteristics of gut bacteria by 16S rRNA analysis.…”

Section: Discussionmentioning

confidence: 99%

Network and 16S rRNA Sequencing-Combined Approach Provides Insightal Evidence of Vitamin K2 for Salt-Sensitive Hypertension

Liu

Chen

et al. 2021

Front. Nutr.

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Vitamin K2 (VK2), found to act to treat hypertension, has been widely used in the food and pharmaceutical industries nowadays. However, the potential targets and molecular mechanisms of VK2 for salt-sensitive hypertension have not been fully investigated. Therefore, the study aimed to investigate the potential molecular mechanisms of VK2 for salt-sensitive hypertension using network pharmacology and 16S rRNA sequencing strategy. The network pharmacology-based findings from KEGG enrichment analysis revealed that VK2-treated salt-sensitive hypertension was mechanically associated with the complement and coagulation cascades, calcium signaling pathway, renin–angiotensin system, etc. A total of 29 different bacteria in an animal experiment after VK2 supplementation were screened and functionally enriched using PICRUSt2. Additionally, 10 signaling pathways were identified in which the renin–angiotensin system was found to be the potential molecular mechanisms with the greatest change in multiple and statistical significance. Moreover, the results of the renin–angiotensin system-related protein expression exhibited VK2-inhibited renin–angiotensin system in salt-induced hypertensive mice, which significantly verified the previous biological and functional prediction analysis. Finally, spearman correlation analysis showed the different bacteria such as Dubosiella, Ileibacterium, etc., had a positive or negative correlation with renin–angiotensin system-related proteins in salt-induced mice. In conclusion, the potential molecular mechanisms of VK2 for salt-sensitive hypertension may be beneficially achieved by the specific inhibition of the renin–angiotensin system, contributing to the development for a new preventive strategy of salt-sensitive hypertension.

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Regulation Effect of a Chinese Herbal Formula on Flora and Mucosal Immune Secretory Immunoglobulin A in Rats

Cited by 11 publications

References 26 publications

Laetiporus sulphureus–fermented wheat bran enhanced the broiler growth performance by improving the intestinal microflora and inflammation status

Laetiporus sulphureus–fermented wheat bran enhanced the broiler growth performance by improving the intestinal microflora and inflammation status

Bacterial association and comparison between lung and intestine in rats

Network and 16S rRNA Sequencing-Combined Approach Provides Insightal Evidence of Vitamin K2 for Salt-Sensitive Hypertension

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