Regulation effect of miR-7 on intervening colorectal cancer rats with HP infection through Akt/GSK-3β/β-catenin pathway

Su, Xin; Wang, Wenbin; Ma, Siyang; Ning, Huahan; Chen, Jiaxi

doi:10.14715/cmb/2022.68.6.22

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…Colorectal cancer (CRC) is a high-risk digestive tract tumor throughout the world. Its mortality ranks third in Western countries (1)(2)(3). With the increased obesity rate, changing lifestyle and insufficient physical activity, the incidence of CRC gradually increasing in China.…”

Section: Introductionmentioning

confidence: 99%

LINC00339 accelerates invasion and migration of colorectal cancer via mediating miRNA-30a-5p

Peng Zhou,

Jie Wu,

Zihan Zheng

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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Section: Introductionmentioning

confidence: 99%

LINC00339 accelerates invasion and migration of colorectal cancer via mediating miRNA-30a-5p

Peng Zhou,

Jie Wu,

Zihan Zheng

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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DR6 Augments Colorectal Cancer Cell Growth, Invasion, and Stemness by Activating AKT/NF-κB Pathway

Jia,

Huang,

Chen

et al. 2024

Biochem Genet

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This study aims to elucidate the role and mechanisms of Death Receptor 6 (DR6), a member of the tumor necrosis factor receptor superfamily, in the malignant progression of colorectal cancer (CRC). The association of DR6 expression levels and CRC patient survival was examined using the CRC cohort data from GEPIA database. The functional role of DR6 in CRC cells was investigated by performing loss-of-function and gain-of-function experiments based on CCK-8 proliferation assay, transwell migration and invasion assay, and sphere-forming assays. Xenograft model of CRC cells in nude mouse was established to evaluate the impact of DR6 knockdown on CRC tumorigenesis. Elevated expression of DR6 was correlated with an unfavorable prognosis in CRC patients. In vitro functional assays demonstrated that silencing DR6 considerably suppressed the proliferation, migration, invasion, and stemness of CRC cells, whereas its overexpression showed an opposite effect. DR6 knockdown also attenuated tumor formation of CRC cells in the nude mice. Mechanistically, silencing DR6 reduced the phosphorylation of AKT and NF-κB in CRC cells, and the treatment with an AKT activator (SC79) abrogated the inhibitory effects of DR6 knockdown on the malignant features of CRC cells. Our data suggest that DR6 contributes to the malignant progression of CRC by activating AKT/NF-κB pathway, indicating its clinical potential as a prognostic marker and therapeutic target for CRC.

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The intestinal flora and nutritional status and immune function characteristics of obese colon cancer patients

Yuan,

Zhang,

et al. 2024

BMC Gastroenterol

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Background The research aims to explore the characteristics of intestinal flora, nutritional status and immune function in patients with different types of obese colon cancer. Methods A retrospective analysis is conducted on 64 cases of obese colon cancer diagnosed from June 2018 to January 2020. According to the histological staging of the cancer, they are classified into adenocarcinoma, adenosquamous carcinoma and undifferentiated carcinoma, with corresponding cases of 24, 22 and 18, respectively. The intestinal flora (Bifidobacterium, Lactobacillus, Enterococcus faecalis, Escherichia coli, and yeast), nutritional status (Hb, Alb, PA, TFN, and PNI), immune function (IgG, IgM, IgA, CD4+, CD8+, and CD4+/CD8+) are analyzed in the different groups of patients. Survival curves are evaluated by Kaplan-Meier method and log-rank test for tumour death, local recurrence, and distant metastasis. Results There were no statistically significant differences in intestinal flora (Bifidobacterium, Lactobacillus, Enterococcus faecalis, Escherichia coli, and yeast), nutritional status (Hb, Alb, PA, TFN, and PNI) and immune function (IgG, IgM, IgA, CD4+, CD8+, and CD4+/CD8+) between different groups. There was a significant correlation between intestinal flora, nutritional status and immune function for all three. The survival curves of tumour death, local recurrence and distant metastasis in different groups of obese colon cancer patients were statistically significant. The tumor mortality rate, local recurrence, and distant metastasis rate in adenocarcinoma were 78.65%, 54.25% and 48.26% respectively. Conclusion There are differences in intestinal flora, nutritional status and immune function among different types of obese colon cancer patients, but adenocarcinoma has the least benefit in intestinal flora, poor nutritional status, and weakest immune function.

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Regulation effect of miR-7 on intervening colorectal cancer rats with HP infection through Akt/GSK-3β/β-catenin pathway

Cited by 4 publications

References 8 publications

LINC00339 accelerates invasion and migration of colorectal cancer via mediating miRNA-30a-5p

LINC00339 accelerates invasion and migration of colorectal cancer via mediating miRNA-30a-5p

DR6 Augments Colorectal Cancer Cell Growth, Invasion, and Stemness by Activating AKT/NF-κB Pathway

The intestinal flora and nutritional status and immune function characteristics of obese colon cancer patients

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