Regulation effects of naringin on diesel particulate matter-induced abnormal airway surface liquid secretion

Shi, Rui; Su, Weiwei; Zhu, Zhiting; Guan, Minyi; Cheng, Keling; Fan, Weiyang; Wei, Gu-Yi; Li, Peibo; Yang, Zhong; Yao, Hongliang

doi:10.1016/j.phymed.2019.153004

Cited by 23 publications

(16 citation statements)

References 41 publications

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“…The way to establish mice model and the concentration of the PM 2.5 suspension was referenced to the work of Shi et al. ().…”

Section: Methodsmentioning

confidence: 99%

Effects of Total Flavonoids from Exocarpium Citri Grandis on Air Pollution Particle‐Induced Pulmonary Inflammation and Oxidative Stress in Mice

Zhu

et al. 2019

Journal of Food Science

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Exocarpium Citri Grandis (ECG) is a famous traditional Chinese medicine, which has been commonly used to alleviate cough and phlegm for more than several hundred years, and total flavonoids are the main effective components of this medicine. This study investigated the effects of total flavonoids from ECG (TFECG) on pulmonary inflammation and oxidative stress induced by PM 2.5 in mice. Model mice received an intratracheal instillation of PM 2.5 (10 mg/mL) once at day 0. Bronchoalveolar lavage fluid (BALF) was collected after 72 hr to measure the total number of white blood cell (WBC), neutrophils (NEUT), lymphocytes (LYMPH), and monocytes (MONO). The levels of tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β), interleukin-6 (IL-6), and interleukin-18 (IL-18) in BALF were quantified by using enzyme-linked immunosorbent assay kits. Lung tissues were used to determine the contents of total protein (TP), malondialdehyde (MDA), nitric oxide (NO), reduced glutathione (GSH), oxidized glutathione (GSSG) and the activities of superoxide dismutase (SOD), lactate dehydrogenase (LDH), Glutathione Peroxidase (GSH-Px), and inducible nitric oxide synthase (iNOS). We found that TFECG significantly inhibited PM 2.5 -stimulated overproduction of TNF-α, IL-1β, IL-6, and IL-18 and increased the numbers of WBC, NEUT, LYMPH, and MONO in BALF. TFECG observably relieved the PM 2.5 -induced increases in the contents of TP, MDA, and NO, and the activities of LDH and iNOS. TFECG also alleviated PM 2.5 -induced decreases in the activities of iNOS and GSH-Px as well as GSH/GSSG ratio. The results indicate that TFECG has anti-inflammatory and antioxidant activities, which may potentially contribute to the treatment of PM 2.5 -induced lung injury.Practical Application: Exocarpium Citri Grandis (ECG) is rich in flavonoids, which are beneficial to improve antiinflammation and antioxidant capacity. We proved that total flavonoids of ECG had a positive therapeutic effect on PM 2.5 -induced lung injury, which expands the potential applications of ECG in the dietary supplement industries.

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“…The way to establish mice model and the concentration of the PM 2.5 suspension was referenced to the work of Shi et al. ().…”

Section: Methodsmentioning

confidence: 99%

Effects of Total Flavonoids from Exocarpium Citri Grandis on Air Pollution Particle‐Induced Pulmonary Inflammation and Oxidative Stress in Mice

Zhu

et al. 2019

Journal of Food Science

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“…The mRNA expressions of Nrf2, HO-1, and NQO1 were measured by RT-qPCR as previously described [ 63 ]. Total RNA was isolated from Beas-2B cells using RNAiso Plus (TaKaRa, Shiga, Japan).…”

Section: Methodsmentioning

confidence: 99%

Beneficial Effects of Naringenin in Cigarette Smoke-Induced Damage to the Lung Based on Bioinformatic Prediction and In Vitro Analysis

Chen

Xiao

et al. 2020

Molecules

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Naringenin is found mainly in citrus fruits, and is thought to be beneficial in the prevention and control of lung diseases. This study aims to investigate the mechanisms of naringenin against the damage in the lung caused by cigarette smoke. A system bioinformatic approach was proposed to predict the mechanisms of naringenin for protecting lung health. Then, we validated this prediction in BEAS-2B cells treated with cigarette smoke extract (CSE). System bioinformatic analysis indicated that naringenin exhibits protective effects on lung through the inhibition of inflammation and suppression of oxidative stress based on a multi-pathways network, mainly including oxidative stress pathway, Nrf2 pathway, Lung fibrosis pathway, IL-3 signaling pathway, and Aryl hydrocarbon receptor pathway. The in vitro results showed that naringenin significantly attenuated CSE-induced up-regulation of IL-8 and TNF-α. CSE stimulation increased the mRNA expressions of Nrf2, HO-1, and NQO1; the levels of total protein and nuclear protein of Nrf2; and the activity of SOD on days 2 and 4; but decreased these indexes on day 6. Naringenin can balance the antioxidant system by regulating Nrf2 and its downstream genes, preliminarily validating that Nrf2 pathway is involved in the protection offered by naringenin against cigarette smoke-induced damage to the lung. It suggests that dietary naringenin shows possible potential use in the management of lung health.

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“…Furthermore, naringenin (100 µM) could regulate CFTR expression, thereby decreasing the viscosity of sputum in an LPS-induced airway epithelial cell model [103]. In addition, the in vitro and in vivo studies indicated that naringin markedly reduced diesel particulate matter (DPM)-induced liquid viscosity by reducing MUC5AC secretion, increasing CFTR protein expression, and increasing intracellular cAMP to promote CFTR activation [104]. The expectorant effects of naringenin and naringin are summarized in Table 5.…”

Section: Expectorantmentioning

confidence: 99%

Evaluation of Naringenin as a Promising Treatment Option for COPD Based on Literature Review and Network Pharmacology

Chen

et al. 2020

Biomolecules

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Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by incompletely reversible airflow limitation and seriously threatens the health of humans due to its high morbidity and mortality. Naringenin, as a natural flavanone, has shown various potential pharmacological activities against multiple pathological stages of COPD, but available studies are scattered and unsystematic. Thus, we combined literature review with network pharmacology analysis to evaluate the potential therapeutic effects of naringenin on COPD and predict its underlying mechanisms, expecting to provide a promising tactic for clinical treatment of COPD.

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Regulation effects of naringin on diesel particulate matter-induced abnormal airway surface liquid secretion

Cited by 23 publications

References 41 publications

Effects of Total Flavonoids from Exocarpium Citri Grandis on Air Pollution Particle‐Induced Pulmonary Inflammation and Oxidative Stress in Mice

Effects of Total Flavonoids from Exocarpium Citri Grandis on Air Pollution Particle‐Induced Pulmonary Inflammation and Oxidative Stress in Mice

Beneficial Effects of Naringenin in Cigarette Smoke-Induced Damage to the Lung Based on Bioinformatic Prediction and In Vitro Analysis

Evaluation of Naringenin as a Promising Treatment Option for COPD Based on Literature Review and Network Pharmacology

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