Regulation mechanisms of intestinal secretion: implications in nutrient absorption

Wapnir, Raul A.

doi:10.1016/s0955-2863(02)00181-x

Cited by 53 publications

(29 citation statements)

References 117 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PYY is known to induce the feeling of satiety [57]. It is a gastrointestinal hormone that is produced by the enteroendocrine L cells and acts on the intestinal epithelium [58] and on hypothalamus [59], while its secretion is correlated to the amount of ingested calories [60]. Both findings were associated with markedly greater appetite suppression and EBWL compared to the 16 patients that had undergone LRYGBP.…”

Section: Satiety Vs Appetite: the Hormonal Benefit Of Sgmentioning

confidence: 99%

Morbid Obesity and Sleeve Gastrectomy: How Does It Work?

et al. 2010

View full text Add to dashboard Cite

Laparoscopic sleeve gastrectomy is known to be a safe and effective procedure for treating morbid obesity and is performed with increasing frequency both in Europe and the USA. Despite its broad use, many questions about the remaining gastric tube diameter, its long-term efficacy, its effects on gastric emptying, and the hormones involved still remain to be answered. In order to use such a relatively new surgical procedure wisely, it is essential for every surgeon and physician to understand how sleeve gastrectomy acts in obesity and what its potential benefits on the patients' metabolism are. This review focuses on the most important pathophysiologic questions referred to sleeve gastrectomy on the literature so far, in an attempt to evaluate the different issues still pending on the subject.

show abstract

Section: Satiety Vs Appetite: the Hormonal Benefit Of Sgmentioning

confidence: 99%

Morbid Obesity and Sleeve Gastrectomy: How Does It Work?

et al. 2010

View full text Add to dashboard Cite

show abstract

“…The main constituents of intestinal secretion are mucus, enzymes, water, Na þ , Cl 2 , HCO 2 3 and IgA. Intestinal secretion is necessary to obtain a chyme with a concentration of nutrients, water and electrolytes optimal for absorption processes and it also might have a function in the homeostatic mechanism such as the control of fluid and acid -base balance in the body (52) . In pathophysiological conditions, intestinal secretion protects the mucosa by washing away and diluting harmful substances (53) .…”

Section: Antisecretory Factor and Gut Healthmentioning

confidence: 99%

Antisecretory factor as a potential health-promoting molecule in man and animals

2010

View full text Add to dashboard Cite

Antisecretory factor (AF) is a protein secreted in plasma and other tissue fluids in mammals with proven antisecretory and anti-inflammatory activity; its immunohistological distribution suggests a role in the immune system. The expression level and the distribution of AF protein are altered during an immunological response. Exposure to bacterial toxins induces secretion of AF in plasma, probably reflecting a natural defence mechanism to agents causing diarrhoea, thereby contributing to a favourable clinical outcome and disease termination. An increase of AF levels in plasma by dietary means, such as specially processed cereals (SPC), has been demonstrated in human subjects and animals. Administration of SPC to patients affected by inflammatory bowel disease, gastroenteritis and Ménière's disease relieved symptoms and improved quality of life. A recent study showed the positive effect of SPC diet supplementation on prevention of the effects of exposure to low levels of blast overpressure in rats, reducing the extent of intracranial pressure increase and cognitive function impairment. AF-rich egg yolk powder improved health status in children suffering acute and chronic diarrhoea, reducing the frequency and increasing the consistency of stools. This kind of functional food could be used for prophylaxis in populations exposed to a high risk of morbidity and mortality caused by diarrhoea and as a complementary therapy in patients affected by chronic intestinal inflammatory disease to improve well-being. In pig husbandry AF-inducing diets, owing to their antisecretory activity and anti-inflammatory action, are a suitable option as an alternative to antibiotic growth promoters to counteract post-weaning diarrhoea.

show abstract

“…In the gut, NPY inhibits gastrointestinal motility and water and electrolyte secretion, especially ClÀ throughout the entire intestine (Cox, 2007;HolzerPetsche et al, 1991;Hubel and Renquist, 1986;Saria and Beubler, 1985). This behavior has made NPY to be currently investigated as a key molecule for using in anti-diarrheic drugs (Camilleri et al, 2011;Laburthe, 1990;Moriya et al, 2010;Tough et al, 2011;Vona-Davis and McFadden, 2007;Wapnir and Teichberg, 2002).…”

Section: Discussionmentioning

confidence: 99%