Regulation of 25-Hydroxy-Vitamin D-1α-Hydroxylase in Chick Isolated Renal Tubules: Effects of Prostaglandin E2, Frusemide and Acetylsalicylic Acid

Wark, John D.; Larkins, R. G.; Eisman, J. A.; Wilson, Kumanan

doi:10.1042/cs0610053

Cited by 38 publications

(16 citation statements)

References 21 publications

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“…[48] We also did not observe the effect of vitamin D supplementation and weight reduction on these parameters.…”

Section: Discussionmentioning

confidence: 74%

“…[48] We also did not observe the effect of vitamin D supplementation and weight reduction on these parameters.We did not have any information on patients taking nonsteroidal anti-inflammatory drugs (NSAID). Because renal prostaglandins may regulate the 1α-hydroxylase enzyme and thus influence the conversion of 25(OH)D to 1,25(OH)D.[45], NSAIDs by virtue of their inhibitory effect on prostaglandin production might lead to alteration in vitamin D levels.…”

Section: Discussionmentioning

confidence: 99%

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Renin-angiotensin system activity in vitamin D deficient, obese individuals with hypertension: An urban Indian study

Kota

Jammula

et al. 2011

Indian J Endocr Metab

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Background:Elevated renin–angiotensin–aldosterone system (RAAS) activity is an important mechanism in the development of hypertension. Both obesity and 25-hydroxy vitamin D [25(OH)D] deficiency have been associated with hypertension and augmented renin-angiotensin system (RAS) activity. We tried to test the hypothesis that vitamin D deficiency and obesity are associated with increased RAS activity in Indian patients with hypertension.Materials and Methods:Fifty newly detected hypertensive patients were screened. Patients with secondary hypertension, chronic kidney disease, or coronary artery disease were excluded. Patients underwent measurement of vitamin D and plasma renin and plasma aldosterone concentrations. They were divided into three groups according to their baseline body mass index (BMI; normal <25 kg/m2, overweight 25–29.9 kg/m2 and obese ≥30 kg/m2) and 25(OH)D levels (deficient <20 ng/ml, insufficient 20–29 ng/ml and optimal ≥30 ng/ml).Results:A total of 50 (male:female – 32:18) patients were included, with a mean age of 49.5 ± 7.8 years, mean BMI of 28.3 ± 3.4 kg/m2 and a mean 25(OH)D concentration of 18.5 ± 6.4 ng/ml. Mean systolic blood pressure (SBP) was 162.4 ± 20.2 mm Hg and mean diastolic blood pressure (DBP) was 100.2 ± 11.2 mm Hg. All the three blood pressure parameters [SBP, DBP and mean arterial pressure (MAP)] were significantly higher among individuals with lower 25(OH)D levels. The P values for trends in SBP, DBP and MAP were 0.009, 0.01 and 0.007, respectively. Though all the three blood pressure parameters (SBP, DBP and MAP) were higher among individuals with higher BMIs, they were not achieving statistical significance. Increasing trends in PRA and PAC were noticed with lower 25(OH)D and higher BMI levels.Conclusion:Vitamin D deficiency and obesity are associated with stimulation of RAAS activity. Vitamin D supplementation along with weight loss may be studied as a therapeutic strategy to reduce tissue RAS activity in individualswith Vitamin D deficiency and obesity.

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“…[48] We also did not observe the effect of vitamin D supplementation and weight reduction on these parameters.…”

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Renin-angiotensin system activity in vitamin D deficient, obese individuals with hypertension: An urban Indian study

Kota

Jammula

et al. 2011

Indian J Endocr Metab

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“…Fifth, we did not have any measurement of renal prostaglandin production in our participants, or whether they used non-steroidal anti-inflammatory drugs. Because renal prostaglandins may regulate the 1α-hydroxylase enzyme, and thus influence conversion of 25(OH)D to 1,25(OH)D,50 it would have been interesting to perform an additional analysis to test an interaction between vitamin D and renal prostaglandins.…”

Section: Limitationsmentioning

confidence: 99%

Plasma 25-Hydroxyvitamin D and Regulation of the Renin-Angiotensin System in Humans

2010

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Abstract-Vitamin D regulates the renin-angiotensin system (RAS) in experimental animals, but corresponding human data are limited. We examined the relation between plasma 25-hydroxyvitamin D and elements of the RAS in 184 normotensive individuals in high sodium balance; these included circulating levels of plasma renin activity and angiotensin II (Ang II) and the renal plasma flow response to infused Ang II, which is an indirect measure of the intrinsic RAS activity in the kidney. Compared with individuals with sufficient 25-hydroxyvitamin D levels (Ն30.0 ng/mL), those with insufficiency (15.0 to 29.9 ng/mL) and deficiency (Ͻ15.0 ng/mL) had higher circulating Ang II levels (P for trendϭ0.03). Moreover, those with vitamin D deficiency had significantly blunted renal plasma flow responses to infused Ang II (mean decrease of 115 mL/min per 1.73 m 2 in renal plasma flow versus 145 mL/min per 1.73 m 2 among those with sufficient vitamin D levels; P for trendϭ0.009). Although plasma renin activity was higher among individuals with insufficient levels of vitamin D, the result was not statistically significant. These data suggest that low plasma 25-hydroxyvitamin D levels may result in upregulation of the RAS in otherwise healthy humans. A major proposed mechanism linking vitamin D with hypertension involves vitamin D-mediated suppression of the renin-angiotensin (Ang) system (RAS), yet data derive mostly from in vitro and animal studies. [15][16][17][18][19] Human investigation of the association between vitamin D and the RAS has been scant. Resnick et al 20 originally reported that plasma renin activity (PRA) and 1,25-dihydroxyvitamin D (1,25[OH] 2 D) were inversely correlated (rϭϪ0.65) among 61 individuals on an ambient diet. Several years later, Burgess et al 21 reported a similar association in 10 hypertensives (rϭϪ0.76). Interestingly, in a randomized trial that documented a 14-mm Hg decrease in SBP with vitamin D supplementation compared with placebo, the authors also noted a trend toward a decrease in circulating angiotensin II (Ang II) levels (Ϫ13.1 pg/mL; Pϭ0.14) relative to placebo. 22 To test the hypothesis that there is a mechanistic role for vitamin D in the regulation of the RAS in humans, we examined the relation between plasma 25(OH)D concentration with both circulating renin and Ang II levels, as well as the renal plasma flow (RPF) response to infused Ang II, which correlates inversely with endogenous intrarenal RAS activity, 23-27 among 184 normotensive individuals. Methods Study PopulationParticipants in this study included 184 normotensive white and black men and women, recruited as healthy volunteers from the general population, who completed RPF studies in high sodium balance at 1 of 4 General Clinical Research Centers, including Brigham and Women's Hospital in Boston; the University of Utah Medical Center in Salt Lake City, Utah; Vanderbilt University Hospital in Nashville, Tennessee; and the Hô pital Européen Georges Pompidou in Paris, France. We examined normotensive participants because of our...

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“…Further in vitro work by Wark et al [274] in isolated renal tubules, prepared from vitamin-D-deficient chicks, showed that the addition of PGE 2 to the tubule incubation medium in the presence of 1,25(OH) 2 D 3 increased 1,25(OH) 2 D 3 production. Acetylsalicylic acid, which inhibits prostaglandin synthesis, decreased the prostaglandin content of the tubule medium and subsequently inhibited 1,25(OH) 2 D 3 production.…”

Section: Prostaglandinsmentioning

confidence: 96%

Drug and Hormone Effects on Vitamin D Metabolism

Weinstein¹,

Epstein²

2011

Vitamin D

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Regulation of 25-Hydroxy-Vitamin D-1α-Hydroxylase in Chick Isolated Renal Tubules: Effects of Prostaglandin E2, Frusemide and Acetylsalicylic Acid

Cited by 38 publications

References 21 publications

Renin-angiotensin system activity in vitamin D deficient, obese individuals with hypertension: An urban Indian study

Renin-angiotensin system activity in vitamin D deficient, obese individuals with hypertension: An urban Indian study

Plasma 25-Hydroxyvitamin D and Regulation of the Renin-Angiotensin System in Humans

Drug and Hormone Effects on Vitamin D Metabolism

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