Regulation of a multigenic invasion programme by the transcription factor, AP-1: re-expression of a down-regulated gene, TSC-36, inhibits invasion

Cooperative DNA Binding with AP-1 Proteins Is Required for Transformation by EWS-Ets Fusion Proteins

“…These data support the idea that part of the transcriptional program induced by transforming Fos and Jun proteins may involve cooperation with Ets proteins. For example, the gene for HB-EGF has been shown be regulated during cell transformation by v-Jun, and the human collagenase gene is expressed at increased levels in Fos-transformed fibroblasts (10,19). These data are consistent with the idea that oncogenic Fos and Jun may target some promoters by cooperative interactions with Ets proteins.…”

“…We and others have used different approaches to analyze gene expression induced during cell transformation by Fos and Jun proteins (10,19,25,26,35). These data support the idea that part of the transcriptional program induced by transforming Fos and Jun proteins may involve cooperation with Ets proteins.…”

Developmental expression of mouse Follistatin-like 1 (Fstl1): Dynamic regulation during organogenesis of the kidney and lung

“…Fstl1 is inducible by TGFβ (Shibanuma et al, 1993) and estrogen (Ohashi et al, 1997), and has been identified as a potential tumor suppressor (Hodgson et al, 2001). Expression of Fstl1 is reduced in human cancer cell lines (Hambrock et al, 2004;Mashimo et al, 1997;Sumitomo et al, 2000) and experimentally transformed cells (Johnston et al, 2000). Reintroduction of Fstl1 to transformed cells reduces proliferation (Sumitomo et al, 2000) and invasion (Johnston et al, 2000), suggesting that mechanisms of Fstl1 action during embryonic development may be to inhibit cell growth and migration.…”

“…Expression of Fstl1 is reduced in human cancer cell lines (Hambrock et al, 2004;Mashimo et al, 1997;Sumitomo et al, 2000) and experimentally transformed cells (Johnston et al, 2000). Reintroduction of Fstl1 to transformed cells reduces proliferation (Sumitomo et al, 2000) and invasion (Johnston et al, 2000), suggesting that mechanisms of Fstl1 action during embryonic development may be to inhibit cell growth and migration. These actions could be due either to antagonism of Activin/BMP signals which are proliferative in some developmental contexts, or to modification of the extracellular matrix environment.…”

Transcription repression in oncogenic transformation: common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1

“…These signaling events include pathways that activate Fos as well as Fos-independent pathways (Stacey et al, 1987). Subtractive cDNA-based approaches have been performed to identify gene expression profiles in cells transformed by RAS (Zuber et al, 2000) or by v-fos (Johnston et al, 2000). Furthermore, the latter study demonstrated that largescale gene expression analysis can be employed to identify transcriptionally repressed genes that are functionally involved in the suppression of the cell transformation phenotype.…”