Regulation of ATR-dependent DNA damage response by nitric oxide

Abstract

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Oxidative Dysregulation in Early Life Stress and Posttraumatic Stress Disorder: A Comprehensive Review

“…In case of higher energy demand and increased neuronal activity such as in stress, hypoxia, inflammation/injury, and NMDA stimulation, Ca transients together with the 5' AMP-activated protein kinase (AMPK) cascade lead to increased glycolysis and catabolic processes (e.g., fatty acid oxidation) and induction of the inducible isoform of nitric oxide synthase (iNOS) in order to sustain neuronal activity [55]. iNOS induction leads to dysregulation of the NO equilibrium, ONOO − formation, and GSH trafficking decline, collectively causing mitochondrial damage via ROS/RNS generation [56]. Apart from NO, other components of the oxidative phosphorylation cascade such as the HO-1 and GSH pathways and lipid oxidation products (e.g., 4-hydroxynonenal, 4-HNE) are also involved in the generation of ROS (i.e., through pro-oxidant Fe generation) and the promotion of autophagy, senescence, cell cycle arrest, apoptosis, and cell death [57][58][59][60].…”

Recent advances in diverse nanosystems for nitric oxide delivery in cancer therapy

“…The characteristic of NO with radical electrons (lone pair electrons) endows it with reactivity to inorganic molecules (oxygen, superoxide or transition metal), prosthetic groups and DNA structure, thus depicting its wide range of biological activities 19 . The effect of NO is mainly mediated through two methods: cyclic guanosine phosphate (cGMP)-dependent and cGMP-independent.…”

Anti-proliferative, -migratory and -clonogenic effects of long-lasting nitric oxide release in HepG2 cells

“…Such reactivity could be ascribed to either cGMP-dependent or cGMP-independent physiological pathways. 29 Several studies report different mechanisms like inhibition of HIF 1α, 30 mitochondrial respiration, 31 and or DNA synthesis for anticancer effects, and we will surely aim at exploring the mechanism of our results in future studies. We would also like to design combinatorial therapy with nonconventional systems 25 like immunotherapy, PDT (photodynamic therapy), or PTT (photothermal therapy) and work towards overcoming multidrug resistance with NO donor derivatives in the future.…”