Regulation of Autophagy Is a Novel Tumorigenesis-Related Activity of Multifunctional Translationally Controlled Tumor Protein

Lee, Ji Sun; Jang, Eun Hwa; Woo, Hyun Ae; Lee, Kyunglim

doi:10.3390/cells9010257

Cited by 14 publications

(14 citation statements)

References 92 publications

(130 reference statements)

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“…Over the past decade, autophagy has been recognised as a central biological process, essential for maintaining cellular homeostasis; but the involvement of TCTP in this pathway has only recently been investigated. In the 'TCTP book', this aspect of TCTP function has only briefly been touched on in two articles [5,34] and also here, we will not cover it in much detail, since another review article in this Special Issue discussed the role of TCTP and autophagy in relation to tumorigenesis [51].…”

Section: Biological Stress Reactions and Autophagymentioning

confidence: 99%

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Dysregulation of TCTP in Biological Processes and Diseases

Bommer

Telerman

2020

Cells

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Translationally controlled tumor protein (TCTP), also called histamine releasing factor (HRF) or fortilin, is a multifunctional protein present in almost all eukaryotic organisms. TCTP is involved in a range of basic cell biological processes, such as promotion of growth and development, or cellular defense in response to biological stresses. Cellular TCTP levels are highly regulated in response to a variety of physiological signals, and regulatory mechanism at various levels have been elucidated. Given the importance of TCTP in maintaining cellular homeostasis, it is not surprising that dysregulation of this protein is associated with a range of disease processes. Here, we review recent progress that has been made in the characterisation of the basic biological functions of TCTP, in the description of mechanisms involved in regulating its cellular levels and in the understanding of dysregulation of TCTP, as it occurs in disease processes such as cancer.

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Section: Biological Stress Reactions and Autophagymentioning

confidence: 99%

“…The mechanisms of regulated degradation of the TCTP protein were reviewed in detail in [34] and were also covered in a review article in this Special Issue in Cells [51]. Here, we will just briefly summarise the few cases known today (Table 2).…”

Section: Regulation Of Protein Degradationmentioning

confidence: 99%

Dysregulation of TCTP in Biological Processes and Diseases

Bommer

Telerman

2020

Cells

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“…Autophagy is a mechanism that damages, degenerates or aging protein and organelles in cells are transported to the lysosome for digestion and degradation, leading to the basal turnover of cell components and providing energy and macromolecular precursors [6]. A growing body of research suggests that autophagy genes have a large potential to serve as promising markers in the diagnosis, prognosis, and personalized targeted therapies [7][8][9]. Autophagy mechanisms described in endometrial cancers, including the role of PI3K/AKT/mTOR, AMPK-mTOR, and p53 signaling pathways that trigger or inhibit this process, which may become a potential molecular target in clinical treatment methods [10].…”

Section: Introductionmentioning

confidence: 99%

A bioinformatics study of autophagy biomarkers associated with the prognosis of endometrial carcinoma

Liu

Sun

Bai

et al. 2020

Preprint

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Background: Autophagy plays a critical role in endometrial carcinoma (EC), but prognosis studies of differentially expressed autophagy-related genes (DEARGs) in EC are lacking. This study aimed to access the prognostic value of autophagy-related genes (ARGs) in EC and to identify the potential characteristics of ARGs in predicting patient survival and guiding treatment. Methods:The RNA-Seq data and clinical data were obtained from TCGA databases. The DEARGs were identified by "limma" package in R software. Clusterprofler was used for functional analysis.Using STRING databases to construct a protein-protein interaction (PPI) network and plug-in MCODE to screen hub modules in Cytoscape. The degrees method of cytoHubba was used to select important hub genes. Co-expression analysis was performed using "limma" package and Metascape for functional analysis. Univariate and multivariate Cox proportional hazards regression analyses were performed to construct a prognostic signature. Kaplan-Meier curve analysis, ROC curve analysis and Gene set enrichment analysis (GSEA) were also performed. Validation was executed by UALCAN, CCLE and HPA databases. Results:In total, 45 DEARGs were identified. Functional analysis showed that DEARGs were strikingly enriched in autophagy pathway. PPI network showed that CASP3 was the most central protein. CASP3 co-expression analysis revealed that co-expressed genes were mostly enriched in cell cycle. We identified a novel prognostic signature consisting of 3 genes (CDKN2A, PTK6 and GRID2). The risk score based on the prognostic signature was able to classify patients into high-risk and low-risk groups with significantly different overall survival. Furthermore, the prognostic signature is an independent prognostic predictor of survival and demonstrates superior prognostic performance compared with the clinicopathologic features for predicting 5-year survival. CDKN2A and PTK6 were further validated in UALCAN. GSEA suggested that the two genes played crucial roles in drug metabolism. Conclusion:Using bioinformatics analyses, we identified DEARGs and determined CDKN2A, PTK6 and DRID2 are tumor-associated genes and can be utilized as possible biomarkers in EC treatment.3 Background Endometrial cancer (EC) is the most common gynecologic malignancy and it accounts for 20%-30% of female reproductive system malignancies. Over 300,000 new cases are diagnosed annually, accounting for approximately 8.2% of women's cancer incidence worldwide [1]. An investigation from the American Cancer Society (ACS) reveals that the death rate for endometrial cancer has doubled during the past 20 years [2]. Currently, there are still no validated biological markers to screen EC, early diagnosis is key to improving survival, which at 5 years is less than 20% in advanced disease and over 90% in early-stage disease [1,[3][4][5]. Therefore, it is urgent to develop prognostic or predictive biomarkers for risk assessment to identify high-risk or low-risk patients and to develop appropriate treatment options for them.Autophag...

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“…Previous studies have indicated that autophagy supports the survival and proliferation of cancer cells and metastasis-related behavior (12). Knocking out the FIP200 gene, which is essential for autophagy, inhibited the initiation, progression, and metastasis of breast cancer (12). Inhibition of autophagy using HCQ and Lys05 decreased the proliferation and metastasis of melanoma cells (13).…”

Section: Introductionmentioning

confidence: 99%

“…By contrast, autophagy enables tumor metabolism and growth, promotes the survival of tumor cells under hypoxic conditions as well as tumorigenesis and induces resistance against therapeutic agents (2,4,10,11). Previous studies have indicated that autophagy supports the survival and proliferation of cancer cells and metastasis-related behavior (12). Knocking out the FIP200 gene, which is essential for autophagy, inhibited the initiation, progression, and metastasis of breast cancer (12).…”

Section: Introductionmentioning

confidence: 99%

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Regulation of Autophagy Is a Novel Tumorigenesis-Related Activity of Multifunctional Translationally Controlled Tumor Protein

Cited by 14 publications

References 92 publications

Dysregulation of TCTP in Biological Processes and Diseases

Dysregulation of TCTP in Biological Processes and Diseases

A bioinformatics study of autophagy biomarkers associated with the prognosis of endometrial carcinoma

Table_1.docx

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