Regulation of autophagy of the heart in ischemia and reperfusion

Popov, Sergey; Mukhomedzyanov, A. V.; Воронков, Никита Сергеевич; Derkachev, I. A.; Boshchenko, Alla A.; Fu, Feng; Суфианова, Г. З.; Khlestkina, Maria S.; Маслов, Л Н

doi:10.1007/s10495-022-01786-1

Cited by 55 publications

(31 citation statements)

References 224 publications

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“…There is evidence that diazoxide and pinacidil can protect H9c2 cardiac cells against high glucose‐induced injury by inhibiting necroptosis [134]. Autophagy is a regulated and reversible form of cell death that ensures cell survival under adverse conditions [135, 136]. However, long‐term autophagy is irreversible and resulted in cell death [135].…”

Section: Katp Channels Necroptosis Pyroptosis and Autophagymentioning

confidence: 99%

“…Autophagy is a regulated and reversible form of cell death that ensures cell survival under adverse conditions [135, 136]. However, long‐term autophagy is irreversible and resulted in cell death [135]. Autophagy is a preferred form of cell death in I/R of the heart because it allows cells to survive before the restoration of coronary perfusion [135].…”

Section: Katp Channels Necroptosis Pyroptosis and Autophagymentioning

confidence: 99%

“…However, long‐term autophagy is irreversible and resulted in cell death [135]. Autophagy is a preferred form of cell death in I/R of the heart because it allows cells to survive before the restoration of coronary perfusion [135]. Thus, activation of autophagy is the protective mechanism that protects cardiomyocytes and endothelial cells against I/R.…”

Section: Katp Channels Necroptosis Pyroptosis and Autophagymentioning

confidence: 99%

“…Diazoxide exhibits the delayed anti‐apoptotic effect at I/R of the murine heart, the improvement of cardiac function after reperfusion, and the ant‐necrotic effect [135]. These effects were mediated through enhancement of eNOS and iNOS expression in myocardial tissue.…”

Section: Katp Channels Nitric Oxide and Pkgmentioning

confidence: 99%

“…The iNOS inhibitor S‐methylisothiourea, when injected into eNOS(−/−) mice, completely abolished the beneficial effects of diazoxide. The phosphatidylinositol 3‐kinase (PI3‐kinase) inhibitor wortmannin completely reversed the cardioprotective effect of diazoxide and diazoxide‐induced phosphorylation of Akt kinase, preventing enhancement of eNOS expression [135].…”

Section: Katp Channels Nitric Oxide and Pkgmentioning

confidence: 99%

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K_ATP channels are regulators of programmed cell death and targets for the creation of novel drugs against ischemia/reperfusion cardiac injury

Maslov

Popov

Naryzhnaya

et al. 2023

Fundamemntal Clinical Pharma

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BackgroundThe use of percutaneous coronary intervention (PCI) in patients with ST‐segment elevation myocardial infarction (STEMI) is associated with a mortality rate of 5%–7%. It is clear that there is an urgent need to develop new drugs that can effectively prevent cardiac reperfusion injury. ATP‐sensitive K+ (KATP) channel openers (KCOs) can be classified as such drugs.ResultsKCOs prevent irreversible ischemia and reperfusion injury of the heart. KATP channel opening promotes inhibition of apoptosis, necroptosis, pyroptosis, and stimulation of autophagy. KCOs prevent the development of cardiac adverse remodeling and improve cardiac contractility in reperfusion. KCOs exhibit antiarrhythmic properties and prevent the appearance of the no‐reflow phenomenon in animals with coronary artery occlusion and reperfusion. Diabetes mellitus and a cholesterol‐enriched diet abolish the cardioprotective effect of KCOs. Nicorandil, a KCO, attenuates major adverse cardiovascular event and the no‐reflow phenomenon, reduces infarct size, and decreases the incidence of ventricular arrhythmias in patients with acute myocardial infarction.ConclusionThe cardioprotective effect of KCOs is mediated by the opening of mitochondrial KATP (mitoKATP) and sarcolemmal KATP (sarcKATP) channels, triggered free radicals' production, and kinase activation.

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Section: Katp Channels Necroptosis Pyroptosis and Autophagymentioning

confidence: 99%