Regulation of Axon Growth by Alpha 7 Nicotinic Receptor Calcium Transients at the Growth Cone

Abstract

Amyloids b (Ab) are a hallmark of Alzheimer's disease. They affect the communication between neurons. They can also bind to neuronal targets and thereby affect both intracellular signalling and neuronal electrical activity. During the onset of Alzheimer's disease, a positive feedback loop between Ab40/ 42 and cytosolic calcium is thoughtto accelerate the progression of the disease.