Regulation of B Cell Activity in Man: Role of T Cells

Ballieux, R. E.; Heijnen, Cobi J.; Uytdehaag, Fons G. C. M.; Zegers, B. J. M.

doi:10.1111/j.1600-065x.1979.tb00271.x

Cited by 62 publications

(15 citation statements)

References 70 publications

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“…Other suppressor leukocytes have been described including B lymphocytes (11) and monocytes (12)(13)(14)(15) acting through the release of suppressor mediators, especially prostaglandin E2 (PGE2)' (13)(14)(15)(16). Cell-to-cell interactions between subpopulations of T cells (2,17) or T lymphocytes and monocytes (18) also play an important role in the expression of suppressor activities. The physiological relevance of these various immunoregulatory systems remains undetermined.…”

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confidence: 99%

“…A T helper cell activity was detected in these patients but only in the cell subset bearing receptors for IgG after irradiation. T (1)(2)(3)(4)(5)(6)(7)(8). Suppressor ftinctions have been ascribed predominantly to T lymphocytes activated either by fixation of immune complexes on Fc receptors for IgG (Fcy) (5) or by mitogens, such as concanavalin A (Con A) (4,(7)(8)(9)(10).…”

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“…The yG preparation was injected intramuscularly every 15 d at the dosage of 80 mg/kg, resulting in a reduction of the frequency of infections. All children were investigated prior to, during (48 h after the third or the fourth injection), and after (1)(2)(3)(4)(5)(6)(7)(8) A control group consisting of healthy adult donors or agematched children was studied in parallel. All blood specimens from children were obtained following informed consent by the parents.…”

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confidence: 99%

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Dysfunctions of Pokeweed Mitogen-stimulated T and B Lymphocyte Responses Induced by Gammaglobulin Therapy

Durandy¹,

Fischer²,

Griscelli³

1981

J. Clin. Invest.

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Dysfunctions of Pokeweed Mitogen-stimulated T and B Lymphocyte Responses Induced by Gammaglobulin Therapy

Durandy¹,

Fischer²,

Griscelli³

1981

J. Clin. Invest.

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“…For T cells to produce the specific factor the monocytes need to be HLA-D compatible; however, allogeneic helper factors will function if added to monocytes, providing the latter are syngeneic with the B cells. If T cells are cultured with antigen in the absence of monocytes, specific suppressor factors are elaborated which also can be eluted from antigen coupled columns (Ballieux et al 1979). These do not act by blocking helper factors, but act directly on the helper cells for antibody production.…”

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confidence: 99%

T Cell Receptors and Immunoregulation

Rayfield

1985

J R Soc Med

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“…It has been reported that T cell factors of murine origin can be absorbed on human PBL of certain donors (27) and, vice versa, human T cell factors were shown to activate murine B cells for antibody production (21,28). Heijnen and coworkers (29,30) have demonstrated collaboration between human helper T cell factors and human B cells; however, they worked with antigenic systems to which the response is not genetically controlled and all individuals were expected to respond to them.…”

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Immune response potential to poly(Tyr,Glu)-poly(DLAla)--poly(Lys) of human T cells of different donors.

Katz¹,

Bentwich²,

Eshhar³

et al. 1981

Proc. Natl. Acad. Sci. U.S.A.

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Human peripheral blood T cells ofnormal donors were activated in vitro with autologous adherent cells pulsed with poly(LTyr,LGlu)-poly(DLAla)--poly(LLys) [abbreviated (T,G)-A--L]. The "educated" T cells were tested: (i) for their ability to produce a (T,G)-A--L-specific T cell-replacing factor in the cooperation with B cells for antibody responses in vivo or in vitro and (ii) for their ability to proliferate in the presence of a second stimulus of(T,G)-A--L. Results ofscreening of66 donors demonstrated that educated T cells ofabout 50% ofthe donors produced an active (T,G)-A--L-specific factor, whereas activated cells of only half of the factor producers were capable of proliferating in the presence of the antigen. Thus, as reported for all other species studied, human individuals differ in their response potential to (TG)-A--L.Immune response (Ir) genes have been found in a variety of species (1-4) and therefore it is widely assumed that they must exist in humans. For the majority of antigenic systems studied, Ir genes were found to be linked to the major histocompatibility complex (MHC) ofthe species (1, 2, 5-8). Hence, it is likely that Ir genes in the human will map close to the HLA-D locus because of its similarity to the I region of the mouse (9). The Ir genes also appear to be the obvious candidates to explain involvement ofthe MHC in disease (10). In spite ofthe paramount importance of understanding the function of putative Ir genes in humans, the existence ofsuch genes has not been established yet, probably due to the complexity ofthe antigenic systems that play a role in disease occurrence (10, 11) and due to the ethical constraints on immunizing humans with antigens.One of the antigenic systems most extensively used for studies on the genetic regulation of immune responsiveness in a variety of species is that of the synthetic polypeptide antigen poly(LTyr,LGlu)-poly(DLAla)--poly(Lys), abbreviated as (T,G)-A--L (1, 2, 5, 12, 13). In the mouse, antibody responses (2, 5), delayed-type hypersensitivity (DTH) reactions (14), and antigen-dependent proliferation responses (15) specific to (T,G)-A--L were all found to be genetically controlled. In addition, an antigen-specific T cell-replacing factor that could cooperate with B cells for the production of(T, G)-A--L-specific antibodies has been reported for this synthetic polypeptide (16,17). One of the properties of antigen-specific T cell-replacing factors is their ability to interact with B cells across major histocompatibility (H-2) "barriers" (16, 17), although their production is regulated by Ir genes (16, 18) and they possess Ia determinants (17,19). Furthermore, it has been shown that these factors are not species specific (20,21). It appeared, therefore, that the (T,G)-A--L antigenic system is most adequate for attempts to study genetically controlled immune responses in humans.In the present study we have generated in vitro "educated"human peripheral blood leukocytes (PBL) of normal donors to (T,G)-A--L. The educated cells were tested for t...

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Regulation of B Cell Activity in Man: Role of T Cells

Cited by 62 publications

References 70 publications

Dysfunctions of Pokeweed Mitogen-stimulated T and B Lymphocyte Responses Induced by Gammaglobulin Therapy

Dysfunctions of Pokeweed Mitogen-stimulated T and B Lymphocyte Responses Induced by Gammaglobulin Therapy

T Cell Receptors and Immunoregulation

Immune response potential to poly(Tyr,Glu)-poly(DLAla)--poly(Lys) of human T cells of different donors.

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