Regulation of blood flow in Paget's disease of bone.

Quantification of Skeletal Kinetic Indices in Paget's Disease Using Dynamic18F-Fluoride Positron Emission Tomography

“…An increase in blood flow in pagetic bone is well-recognized both clinically and experimentally. (16,17) A lower mean value of k 2 in pagetic bone is of interest. This indicates a lower rate of transfer from the bone extravascular compartment to plasma.…”

Severe congestive heart failure in elderly patient with Paget’s disease

“…Further evidence for this has been documented by demonstration of an increase in blood flow to the extremities, 10 although it has been suggested that this is mainly caused by cutaneous vasodilation. 11 An echocardiographic study of cardiac function in Paget's disease found that patients with more severe disease had lower peripheral vascular resistance and higher stroke volume. 12 These observations help account for the finding that patients with 15% or more of their skeleton affected by Paget's disease have increased cardiac output.…”

Remission of Psoriasis with Etidronate Treatment of Underlying Paget’s Disease of Bone

“…Bone affected by Paget's disease has in creased blood flow, and this returns to nor mal with treatment [4], The skin overlying bone with active Paget's disease is often erythematous and warm [5] because of vasodilation of the cutaneous blood vessels and increased blood flow [6]. This too reverses with treatment.…”