Regulation of bronchoalveolar lavage fluids cell function by the immunomodulatory agents from Cordyceps sinensis

Kuo, Yu Chi; Tsai, Wei‐Jern; Wang, Joseph Che Yen; Chang, Soon-Jyh; Lin, Ching Yuang; Shiao, Ming‐Shi

doi:10.1016/s0024-3205(00)01011-0

Cited by 90 publications

(65 citation statements)

References 45 publications

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“…C. sinensis possesses anti-tumour properties (Kuo et al, 1994;Yoshida et al, 1989), and one of the mechanisms of inhibiting tumour growth might be activation of the host immune response (Chen et al, 1997;Yamaguchi et al, 1990). The production of cytokines such as interferon (IFN)-ª, tumour necrosis factor (TNF)-AE and interleukin (IL)-12, and the upregulation of phagocytic activity by C. sinensis fractions might play a role in antitumour and anti-bacterial activity (Chen et al, 1997;Kuo et al, 2001;Yamaguchi et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

Cordyceps sinensis mycelium protects mice from group A streptococcal infection

Kuo

Chen

Luo

et al. 2005

Journal of Medical Microbiology

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Group A streptococcus (GAS) infection can cause severe invasive diseases, including necrotizing fasciitis and streptococcal toxic shock syndrome. Cordyceps sinensis, a Chinese herbal medicine, is an immunomodulator. In this study the air-pouch bacterial inoculation model was used to investigate the protective efficacy of C. sinensis mycelium extract against GAS infection. Forcefeeding mice with C. sinensis mycelium extract for 3 consecutive days before GAS infection increased the survival rate and reduced local skin-tissue injury compared with mice fed PBS. Bacterial numbers in the air pouch exudates from C. sinensis-treated mice were lower than those from PBS-treated mice. Blood and organs in PBS-treated mice showed bacterial dissemination, but those in C. sinensis-treated mice did not. Three days of pretreatment with C. sinensis extract followed by C. sinensis treatment every other day after GAS infection resulted in 100 % survival. The post-GAS-infection levels of aspartate aminotransferase, alanine aminotransferase and blood urea nitrogen in the sera of C. sinensis-treated mice were lower than those of PBS-treated mice. Taken together, these results show that C. sinensis mycelium extract protects by decreasing bacterial growth and dissemination, thereby increasing mouse survival rate. IL-12 and IFN-ª expression and macrophage phagocytic activity also increased after C. sinensis treatment.

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Section: Introductionmentioning

confidence: 99%

Cordyceps sinensis mycelium protects mice from group A streptococcal infection

Kuo

Chen

Luo

et al. 2005

Journal of Medical Microbiology

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“…Many of its traditional uses were based on the pharmacological activities, including modulation of immune responses [14], inhibition of tumor growth [1,18,24], decrease of blood pressure [3], increase of hepatic energy metabolism and blood flow [15], and secretion of adrenal hormones [23]. CS can enhance reproductive activity and restore impaired reproductive function in both sexes.…”

Section: Introductionmentioning

confidence: 99%

Regulation of Steroidogenesis byCordyceps sinensisMycelium Extracted Fractions with (hCG) Treatment in Mouse Leydig Cells

Wong

Chen

et al. 2007

Archives of Andrology

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The in vitro effect of extracted fractions of Cordyceps sinensis (CS) mycelium on hCG-treated testosterone production from purified normal mouse Leydig cells was examined. Different fractions extracted from CS (F1-water soluble polysaccharide, F2-water soluble protein and F3-poorly water soluble polysaccharide, and protein) were added to Leydig cells with hCG, and the production of testosterone was determined by radioimmunoassay (RIA). Testosterone productions stimulated by hCG in mouse Leydig cells were suppressed by F2 at 10 mg=ml and F3 at doses from 3 to 10 mg=ml, respectively. F2 and F3 at 10 mg=ml did inhibit dbcAMP-stimulated testosterone productions which indicated that F2 and F3 might affect steroidogenesis at the site after the formation of cyclic AMP. Finally, cycloheximide inhibited F2-and F3-treated mouse Leydig cell testosterone production.

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“…In many studies it has been shown that CS possesses various biological activities that support human homeostasis such as antitumor, 19,20 antioxidant, 21,22 immunomodulatory, [23][24][25] hypoglycemic, 26,27 vasorelaxant activities, 28 and antidepressant activity. 29 A methanol extract from Cordyceps ophioglossoides, a similar parasitic mushroom, was reported to scavenge the reactive oxygen species (ROS) generated by Aβ peptides.…”

mentioning

confidence: 99%

Effects of extracts from Cordyceps sinensis on M1 muscarinic acetylcholine receptor in vitro and in vivo

Chiba

Yamada²,

Torii³

et al. 2010

JRLCR

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Cholinergic dysfunction is implicated in the pathogenesis of memory impairment related to Alzheimer's disease (AD). Accordingly, regulation of M1 muscarinic acetylcholine receptor (M1 mAChR) has been one of the major targets in the development of novel drugs for AD. Utilizing an in vitro system for evaluation of the M1 mAChR, we have recently identified that extracts from Cordyceps sinensis (CS) promote M1 mAChR function. In this study, we examined the effect of pretreatment with several types of CS extracts in F11 neurohybrid cells on ERK phosphorylation induced by a muscarinic agonist, carbachol (CCh). A mixed extract of a hot water extract and an ethanol extract from CS augmented ERK phosphorylation by CCh presumably through upregulation of M1 mAChR function. We further examined the effect of oral administration of CS extracts on memory impairment induced by a muscarinic antagonist scopolamine in mice, finding that CS extracts ameliorated scopolamine-induced amnesia in vivo, consistent with the in vitro data. Thus CS extracts may contribute to the prevention of memory impairment related to AD.

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Regulation of bronchoalveolar lavage fluids cell function by the immunomodulatory agents from Cordyceps sinensis

Cited by 90 publications

References 45 publications

Cordyceps sinensis mycelium protects mice from group A streptococcal infection

Cordyceps sinensis mycelium protects mice from group A streptococcal infection

Regulation of Steroidogenesis byCordyceps sinensisMycelium Extracted Fractions with (hCG) Treatment in Mouse Leydig Cells

Effects of extracts from Cordyceps sinensis on M1 muscarinic acetylcholine receptor in vitro and in vivo

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