Regulation of C6 glioma cell migration by thymol

Lee, Kang Pa; Kim, Jai‐Eun; Park, Won‐Hwan; Hong, Heeok

doi:10.3892/ol.2016.4237

Cited by 23 publications

(9 citation statements)

References 29 publications

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“…[55,58] Similarly, high levels of MMP2 in venous leg ulcers and diabetic foot ulcers [58] also seem to hinder the wound healing. In this context, carvacrol and thymol are also able to downregulate MMP9 and MMP2 in several experimental conditions [41,[59][60][61][62] and these effects can be interesting to the management of chronic wounds.…”

Section: Discussionmentioning

confidence: 99%

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

Costa

Durço

Rabelo

et al. 2019

Journal of Pharmacy and Pharmacology

107

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Objectives The treatment of wounds accounts for a considerable fraction of health expenses as well as serious socioeconomic problems. The use of natural substances stands out as a source of new therapeutic discoveries for the wound healing. Thus, this review compiled scientific findings on the applicability of carvacrol and thymol, or essential oils containing at least one of these compounds, for the treatment of wounds. Methods This review was performed at PubMed, SCOPUS, Web of Science databases using keywords as wound healing, thymol/carvacrol and essential oils. Thirteen studies were selected for discussion. Key findings Thymol/carvacrol was able to act in the three phases of wound healing. In the first phase, they showed modulatory effect of the inflammatory cytokines, oxidative stress and antimicrobial power. In the second phase, they promoted re‐epithelialization, angiogenesis and development of granulation tissue. Finally, in the third phase, they improve the collagen deposition and modulated the growth of fibroblasts and keratinocytes. Conclusions These compounds present a high potential for the development of new therapeutic for wound repair. However, dose, efficacy and safety of these compounds for the treatment of wounds, as well as the mechanisms by which those effects can be observed, are challenges for future studies.

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Section: Discussionmentioning

confidence: 99%

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

Costa

Durço

Rabelo

et al. 2019

Journal of Pharmacy and Pharmacology

107

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“…Thymol (30 μM) treatment in C6 glioma cells was found to reduce fetal bovine serum induced migration. It also diminished matrix metallopeptidase-9 (MMP9) and matrix metallopeptidase-2 (MMP2) production as well as protein kinase Cα (PKCα) and extracellular signal-regulated kinases (ERK1/2) phosphorylation ( Lee et al, 2016 ).…”

Section: Thymol In Cancer Cellsmentioning

confidence: 99%

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

et al. 2017

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Thymol, chemically known as 2-isopropyl-5-methylphenol is a colorless crystalline monoterpene phenol. It is one of the most important dietary constituents in thyme species. For centuries, it has been used in traditional medicine and has been shown to possess various pharmacological properties including antioxidant, free radical scavenging, anti-inflammatory, analgesic, antispasmodic, antibacterial, antifungal, antiseptic and antitumor activities. The present article presents a detailed review of the scientific literature which reveals the pharmacological properties of thymol and its multiple therapeutic actions against various cardiovascular, neurological, rheumatological, gastrointestinal, metabolic and malignant diseases at both biochemical and molecular levels. The noteworthy effects of thymol are largely attributed to its anti-inflammatory (via inhibiting recruitment of cytokines and chemokines), antioxidant (via scavenging of free radicals, enhancing the endogenous enzymatic and non-enzymatic antioxidants and chelation of metal ions), antihyperlipidemic (via increasing the levels of high density lipoprotein cholesterol and decreasing the levels of low density lipoprotein cholesterol and low density lipoprotein cholesterol in the circulation and membrane stabilization) (via maintaining ionic homeostasis) effects. This review presents an overview of the current in vitro and in vivo data supporting thymol’s therapeutic activity and the challenges concerning its use for prevention and its therapeutic value as a dietary supplement or as a pharmacological agent or as an adjuvant along with current therapeutic agents for the treatment of various diseases. It is one of the potential candidates of natural origin that has shown promising therapeutic potential, pharmacological properties and molecular mechanisms as well as pharmacokinetic properties for the pharmaceutical development of thymol.

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“…Besides the efficient use of simply produced QDs, the labelling of living cells as performed in this work, potentially may be used as a model for a better understanding of crucial factors that underly the aggressive nature of gliomas [20] and their infiltration in central nervous system.…”

Section: Nanoparticles Under Such Conditions Constitute Examples Of Lmentioning

confidence: 99%

Colloidal quantum dots suitability for long term cell imaging

Farias

Galembeck

Milani

et al. 2018

Preprint

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Fluorescent semiconductor nanoparticles in tree-dimensional quantum confinement, quantum dots (QDs), synthesized in aqueous medium, and functionalized with polyethylene glycol, were used as probes for the long-term imaging of glial cells. In vitro living healthy as well as cancer glial cells were labelled by direct insertion of a small volume of QDs contained in aqueous suspension into the culture wells. A long-term monitoring (over 7 days) of the cells was performed and no evidence of cell fixation and/or damage was observed. Two control groups, healthy and cancer glial cells, were used to compare cell viability. During the observation period, labelled and non labelled cells presented the same dynamics and no difference was observed regarding cell viability. To our knowledge, this is the first report of the viability of hydrophilic prepared quantum dots without any further surface treatment than the polyethylene-glycol coverage for the long-term imaging of living cells. Further, the study also permitted the observation of two distinct interaction mechanisms between cells and QDs. Healthy glial cells were mainly labelled at their surface, while non-healthy glial cells have shown a high rate in the uptake of QDs.

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Regulation of C6 glioma cell migration by thymol

Cited by 23 publications

References 29 publications

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

Effects of Carvacrol, Thymol and essential oils containing such monoterpenes on wound healing: a systematic review

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

Colloidal quantum dots suitability for long term cell imaging

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