Regulation of Carotenoid Biosynthesis

Bramley, Peter M.; Mackenzie, A.

doi:10.1016/b978-0-12-152829-4.50009-4

Cited by 74 publications

(34 citation statements)

References 277 publications

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“…A translational product specific to the mRNA from the highly illuminated cells resembles in electrophoretic mobility the major light-induced, in vivo synthesized protein. tion in Chlorella mutants and in Euglena (15), but activation ofgene expression has been demonstrated to be the prevailing mechanism in some fungi (8,15). Thus, at least three carotenogenic enzymes, the products of the albino genes, are synthesized de novo in blue light induced mycelia of Neurospora crassa (9).…”

Section: Effect Of High Light Intensity On Protein and Mrna Profilesmentioning

confidence: 99%

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Photoinduction of Massive β-Carotene Accumulation by the Alga Dunaliella bardawil

Lers¹,

Biener²,

Zamir³

1990

Plant Physiol.

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Section: Effect Of High Light Intensity On Protein and Mrna Profilesmentioning

confidence: 99%

“…The regulation of carotene biosynthesis as a function of developmental stage or environmental changes has been studied in a host of organisms ranging from bacteria to higher plants. In most, although not all instances carotene biosynthesis has been found to exhibit a partial or complete dependence on light (for reviews see references 2,8,10,15).…”

mentioning

confidence: 99%

Photoinduction of Massive β-Carotene Accumulation by the Alga Dunaliella bardawil

Lers¹,

Biener²,

Zamir³

1990

Plant Physiol.

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“…It regulates the accumulation of carotenoids in higher plants, algae, fungi and some non-photosynthetic bacteria (Bramley and MacKenzie, 1988;Rau, 1988). Such is the case in the Gram-negative, non-1 orfl ( c r t~)…”

mentioning

confidence: 99%

A Cluster of Structural and Regulatory Genes for Light‐Induced Carotenogenesis in Myxococcus xanthus

Botella

Murillo

Ruiz‐Vázquez

1995

European Journal of Biochemistry

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In the bacterium Myxococcus xanthus, several genes for carotenoid synthesis lie together at the carAcarB chromosomal locus and are co-ordinately activated by blue light. A 12-kb DNA stretch from wildtype M. xanthus has been sequenced that includes the entire carA-carB gene cluster. According to sequence analysis, the cluster contains 11 different genes. Intergenic distances are very short or nil (implying translational coupling), giving further support to previous evidence indicating that most (or all) of the genes in the cluster form a single operon. At the promoter region, a potential -35 site for the binding of ~7 factors is found. However, the -10 region shows little similarity with analogous sites in other bacterial promoters. Five (possibly six) genes in the curA-curB operon code for enzymes acting on early or late steps of the pathway for carotenoid synthesis. Other genes in the operon show no overall similarity with previously known genes. However, peptide stretches in the predicted products of two genes exhibit strong similarity with the DNA binding domain of the MerR family of transcriptional regulators. At least one of the predicted DNA-binding domains is altered in a mutant strain affected in light-regulation of the car genes.

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“…Carotenoids are synthesized in all photosynthetic organisms and in many nonphotosynthetic bacteria and fungi (17), and they are the precursors of vitamin A in mammals (3,31). The composition, accumulation, and localization of carotenoid pigments are subject to regulation by photoinduction, stage of development, formation of chloroplasts, and transition from chloroplasts to chromoplasts (5).…”

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confidence: 99%

Cloning, sequence, and photoregulation of al-1, a carotenoid biosynthetic gene of Neurospora crassa.

Schmidhauser¹,

Lauter²,

Russo³

et al. 1990

Mol. Cell. Biol.

167

111

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Carotenoid biosynthesis is regulated by blue light during growth of Neurospora crassa mycelia. We have cloned the al-1 gene of N. crassa encoding the carotenoid-biosynthetic enzyme phytoene dehydrogenase and present an analysis of its structure and regulation. The gene encodes a 595-residue polypeptide that shows homology to two procaryotic carotenoid dehydrogenases. RNA measurements showed that the level of al-1 mRNA increased over 70-fold in photoinduced mycelia. Transcription run-on studies indicated that the al-1 gene was regulated at the level of initiation of transcription in response to photoinduction. The photoinduced increase of al-1 mRNA levels was not observed in two Neurospora mutants defective in all physiological photoresponses. Analysis of cosmid containing al-1 and of a translocation strain with a breakpoint within al-1 indicated that al-1 transcription proceeds towards the centromere of linkage group I of N. crassa.

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Regulation of Carotenoid Biosynthesis

Cited by 74 publications

References 277 publications

Photoinduction of Massive β-Carotene Accumulation by the Alga Dunaliella bardawil

Photoinduction of Massive β-Carotene Accumulation by the Alga Dunaliella bardawil

A Cluster of Structural and Regulatory Genes for Light‐Induced Carotenogenesis in Myxococcus xanthus

Cloning, sequence, and photoregulation of al-1, a carotenoid biosynthetic gene of Neurospora crassa.

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