Regulation of CD28 binding to SH2 domains of Grb2 and PI3K by trisubstituted carboranes for T-cell activation

Ogawa, Seishi; Asawa, Yasunobu; Iiyama, Momoka; Yoshimori, Atsushi; Nakamura, Hiroyuki; Oda, Masayuki

doi:10.1016/j.bmcl.2022.129049

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Crosstalk Between Dcs and T Cells1

Dcs Interact With T Cells At the Immune Synapse1

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2023

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(2 citation statements)

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“…As a result, Tn–TSCM–TCM–TEM–TTE forms the initial immune response and memory immune response, which allows the body to combat both the “old” antigens produced by tumor recurrence and the “new” ones generated by tumor variation 71,72 . After CD28 activation, signaling pathways like PI3K/Akt 73 and nuclear factor‐κB 74 are activated, which contributes to completing the development, differentiation, and proliferation of Tn and Tm. This results in effector T cells that can eliminate tumors and other pathogens.…”

Section: Crosstalk Between Dcs and T Cellsmentioning

confidence: 99%

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The DC–T cell axis is an effective target for the treatment of non‐small cell lung cancer

Wang,

Zhang,

Cui

et al. 2023

Immunity Inflam & Disease

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The dendritic cell (DC)‐T cell axis is a bridge that connects innate and adaptive immunities. The initial immune response against tumors is mainly induced by mature antigen‐presenting DCs. Enhancing the crosstalk between DCs and T cells may be an effective approach to improve the immune response to non‐small cell lung cancer (NSCLC). In this article, a review was made of the interaction between DCs and T cells in the treatment of NSCLC and how this interaction affects the treatment outcome.

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Section: Crosstalk Between Dcs and T Cellsmentioning

confidence: 99%

“…like PI3K/Akt 73 and nuclear factor-κB 74 are activated, which contributes to completing the development, differentiation, and proliferation of Tn and Tm. This results in effector T cells that can eliminate tumors and other pathogens.…”

Section: Dcs Interact With T Cells At the Immune Synapsementioning

confidence: 99%