Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein DDX5

Louis, Tiani L.; Wong, William H.; Yao, Priscilla; Kurd, Nadia; Tysl, Tiffani; Indralingam, Cynthia S.; Ma, Shengyun; Huang, Wendy; Chang, John T.

doi:10.4049/jimmunol.2200778

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…CD8+ T cells are at the forefront of the adaptive immune response, bearing crucial responsibility for identifying and eliminating malignant or compromised cells [28]. In the tumor microenvironment, the presence and activity level of these cells often signify the effectiveness of the immune response against tumors.…”

Section: Discussionmentioning

confidence: 99%

DDX5 Functions as a Tumor Suppressor in Tongue Cancer

Liu,

Sun,

Long

et al. 2023

Cancers

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DEAD-box polypeptide 5 (DDX5), a DEAD-box RNA helicase, is a multifunctional protein that plays important roles in many physiological and pathological processes. Contrary to its documented oncogenic role in a wide array of cancers, we herein demonstrate that DDX5 serves as a tumor suppressor in tongue cancer. The high expression of DDX5 is correlated with better prognosis for clinical tongue cancer patients. DDX5 downregulates the genes associated with tongue cancer progression. The knockdown of DDX5 promotes, while the overexpression of DDX5 inhibits, tongue cancer proliferation, development, and cisplatin resistance. Furthermore, the expression of DDX5 in tongue cancer is associated with immune cell infiltration in the tumor microenvironment. Specifically, the expression of DDX5 is associated with the reduced infiltration of M2 macrophages and increased infiltration of T cell clusters, which may contribute to anticancer effects in the tumor microenvironment. In this study, we establish DDX5 as a valuable prognostic biomarker and an important tumor suppressor in tongue cancer.

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Section: Discussionmentioning

confidence: 99%

DDX5 Functions as a Tumor Suppressor in Tongue Cancer

Liu,

Sun,

Long

et al. 2023

Cancers

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What's in a name: the multifaceted function of DNA‐ and RNA‐binding proteins in T cell responses

Bresser,

Popović,

Wolkers

2024

The FEBS Journal

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Cellular differentiation allows cells to transition between different functional states and adapt to various environmental cues. The diversity and plasticity of this process is beautifully exemplified by T cells responding to pathogens, which undergo highly specialized differentiation tailored to the ongoing infection. Such antigen‐induced T cell differentiation is regulated at the transcriptional level by DNA‐binding proteins and at the post‐transcriptional level by RNA‐binding proteins. Although traditionally defined as separate protein classes, a growing body of evidence indicates an overlap between these two groups of proteins, collectively coined DNA/RNA‐binding proteins (DRBPs). In this review, we describe how DRBPs might bind both DNA and RNA, discuss the putative functional relevance of this dual binding, and provide an exploratory analysis into characteristics that are associated with DRBPs. To exemplify the significance of DRBPs in T cell biology, we detail the activity of several established and putative DRBPs during the T cell response. Finally, we highlight several methodologies that allow untangling of the distinct functionalities of DRBPs at the DNA and RNA level, including key considerations to take into account when applying such methods.

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Regulation of CD8 T Cell Differentiation by the RNA-Binding Protein DDX5

Cited by 2 publications

References 39 publications

DDX5 Functions as a Tumor Suppressor in Tongue Cancer

DDX5 Functions as a Tumor Suppressor in Tongue Cancer

What's in a name: the multifaceted function of DNA‐ and RNA‐binding proteins in T cell responses

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