Regulation of cell proliferation and apoptosis by growth hormone during zebrafish auditory hair cell regeneration

Rajadinakaran, Gopinath; Sun, Huifang; Rinehart, Claire A.; Rouchka, Eric C.; Smith, Michael E.

doi:10.1186/1471-2105-13-s12-a3

Cited by 1 publication

(1 citation statement)

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“…Phosphorylated STATs form dimers that enter the nucleus, where they bind to specific DNA sequences and activate their target genes and other signaling pathways [ 80 ]. This activation mechanism has been demonstrated in zebrafish, promoting regeneration of hair cells [ 82 ]. In addition, GH has shown to exert anti-inflammatory actions, for example by modifying the immunoreactivity of TNF receptors [ 83 ], as well as modifying neuronal excitation and neuroplasticity through up-regulation of the NR2B subunit of the NMDA receptor [ 71 ], and it also increases the number of neurons that increase the expression of c-Fos in BLA (basolateral complex amygdala) [ 72 ].…”

Section: Molecular Mechanisms Of Gh-dependent Neuroprotection Synmentioning

confidence: 99%

Growth Hormone and the Auditory Pathway: Neuromodulation and Neuroregeneration

Guerra¹,

Devesa²

2021

IJMS

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Growth hormone (GH) plays an important role in auditory development during the embryonic stage. Exogenous agents such as sound, noise, drugs or trauma, can induce the release of this hormone to perform a protective function and stimulate other mediators that protect the auditory pathway. In addition, GH deficiency conditions hearing loss or central auditory processing disorders. There are promising animal studies that reflect a possible regenerative role when exogenous GH is used in hearing impairments, demonstrated in in vivo and in vitro studies, and also, even a few studies show beneficial effects in humans presented and substantiated in the main text, although they should not exaggerate the main conclusions.

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