Regulation of central 5-HT2A receptors: a review of in vivo studies

Eison, Arlene S.; Mullins, U. Lena

doi:10.1016/0166-4328(96)00092-7

Cited by 85 publications

(34 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the present study, 1-and 3-week administration of imipramine reduced the binding of [ (Eison and Mullins 1996;Roth et al 1998). Because imipramine has a relatively high affinity for 5-HT 2A receptors and antagonist activity at these receptors, it is not surprising that its administration for 1 week decreased the number of cortical 5-HT 2A receptors.…”

Section: Discussionsupporting

confidence: 52%

Chronic Effects of Triiodothyronine in Combination with Imipramine on 5-HT Transporter, 5-HT1A and 5-HT2A Receptors in Adult Rat Brain

Moreau

Jeanningros

Mazzola-Pomietto

2001

Neuropsychopharmacology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 52%

Chronic Effects of Triiodothyronine in Combination with Imipramine on 5-HT Transporter, 5-HT1A and 5-HT2A Receptors in Adult Rat Brain

Moreau

Jeanningros

Mazzola-Pomietto

2001

Neuropsychopharmacology

View full text Add to dashboard Cite

“…PYY , cholecystokinin, amylin, and GLP-1 act at G protein coupled receptors. Numerous studies have demonstrated that prolonged exposure of G protein coupled receptors to agonists can induce receptor downregulation and tolerance (6,14,19,26,37). This likely explains why intermittent IV infusions of PYY(3-36) in our experimental model produced a sustained reduction in daily food intake, whereas continuous subcutaneous infusion of PYY produces only a transient suppression of feeding (31,39).…”

Section: Discussionmentioning

confidence: 84%

Daily, intermittent intravenous infusion of peptide YY(3-36) reduces daily food intake and adiposity in rats

Chelikani

Haver²,

Reeve³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

reduces food intake and weight gain in rats when injected into the peritoneal cavity twice daily for 7 days. Numerous laboratories have failed to confirm that daily injections of PYY(3-36) decrease body weight. Continuous subcutaneous administration of PYY(3-36) by osmotic minipump has been reported to reduce daily food intake in rodents but only during the first 3-4 days of administration. Here we show the effects of different daily patterns of intravenous infusion of PYY(3-36) on food intake, body weight, and adiposity in rats tethered via infusion swivels to computercontrolled pumps. Measurement of food bowl weight recorded by computer every 20 s permitted daily assessment of the instantaneous effects of PYY(3-36) administration on food intake and meal patterns. One-hour intravenous infusions of PYY(3-36) at 30 pmol ⅐ kg Ϫ1 ⅐ min Ϫ1 every other hour for 10 days produced a sustained reduction in daily food intake of ϳ20% and decreased body weight and adiposity by 7 and 35%, respectively. Thus dosage pattern is critical for producing a sustained effect of PYY(3-36) on food intake and adiposity.gastrointestinal; body weight; body composition THE GASTROINTESTINAL SYSTEM plays an important sensing and signaling role in control of food intake and regulation of energy reserves (5). A growing number of peptide signals of gastric, intestinal, and pancreatic origin have been shown to inhibit short-term food intake when administered acutely to experimental animals and humans. These include cholecystokinin, amylin, glucagon-like peptide-1 (GLP-1), oxyntomodulin, peptide YY(3-36) ], pancreatic polypeptide, gastrinreleasing peptides (GRPs) GRP-27 and GRP-

show abstract

“…Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid (CSF 5-HIAA) levels were found in subjects recovered from AN (Kaye et al, 1991) and from BN , raising the possibility that they have increased 5-HT activity with increased extracellular 5-HT concentration. Furthermore, studies in animals confirm that reduced 5-HT 2A receptor density occurs in response to increased intrasynaptic 5-HT (Rioux et al, 1999;Saucier et al, 1998) or 5-HT agonists (Eison and Mullins, 1996).…”

Section: Only Rec An Have Reduced [mentioning

confidence: 82%

Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness

Bailer

Price

Meltzer

et al. 2004

Neuropsychopharmacol

154

107

View full text Add to dashboard Cite

Several lines of evidence suggest that a disturbance of serotonin neuronal pathways may contribute to the pathogenesis of anorexia nervosa (AN) and bulimia nervosa (BN). This study applied positron emission tomography (PET) to investigate the brain serotonin 2A (5-HT 2A ) receptor, which could contribute to disturbances of appetite and behavior in AN and BN. To avoid the confounding effects of malnutrition, we studied 10 women recovered from bulimia-type AN (REC AN-BN, 41 year normal weight, regular menstrual cycles, no binging, or purging) compared with 16 healthy control women (CW) using PET imaging and a specific 5-HT 2A 18 F]altanserin binding potential and drive for thinness in several cortical regions. In conclusion, this study extends research suggesting that altered 5-HT neuronal system activity persists after recovery from bulimia-type AN, particularly in subgenual cingulate regions. Altered 5-HT neurotransmission after recovery also supports the possibility that this may be a trait-related disturbance that contributes to the pathophysiology of eating disorders. It is possible that subgenual cingulate findings are not specific for AN-BN, but may be related to the high incidence of lifetime major depressive disorder diagnosis in these subjects.

show abstract

Regulation of central 5-HT2A receptors: a review of in vivo studies

Cited by 85 publications

References 38 publications

Chronic Effects of Triiodothyronine in Combination with Imipramine on 5-HT Transporter, 5-HT1A and 5-HT2A Receptors in Adult Rat Brain

Chronic Effects of Triiodothyronine in Combination with Imipramine on 5-HT Transporter, 5-HT1A and 5-HT2A Receptors in Adult Rat Brain

Daily, intermittent intravenous infusion of peptide YY(3-36) reduces daily food intake and adiposity in rats

Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness

Contact Info

Product

Resources

About