Regulation of cerebral blood flow by arterial PCO<sub>2</sub> independent of metabolic acidosis at 5050 m

Caldwell, Hannah G.; Smith, Kurt J.; Lewis, Nia C. S.; Hoiland, Ryan L.; Willie, Christopher K.; Lucas, Samuel J. E.; Stembridge, Mike; Burgess, Keith R.; MacLeod, David B.; Ainslie, Philip N.

doi:10.1113/jp281446

Cited by 7 publications

(15 citation statements)

References 102 publications

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“…Whether a minimal concentration of bicarbonate is essential to sustain cerebrovascular and neurological function is of interest, particularly in the context of high-altitude ascent where the adaptive renal response is to augment bicarbonate secretion. The technically elegant study by Caldwell et al (2021b) provides insight into the interaction between acid-base physiology and cerebrovascular regulation, showcasing P aCO 2 as a key mediator in CBF regulation.…”

Section: Discussion and Future Considerationsmentioning

confidence: 99%

“…The technically elegant study by Caldwell et al . (2021 b ) provides insight into the interaction between acid–base physiology and cerebrovascular regulation, showcasing

P_{aC O_{2}}

as a key mediator in CBF regulation.…”

Section: Background Physiologymentioning

confidence: 99%

“…In a recent publication in The Journal of Physiology , Caldwell et al . (2021 b ) sought to examine the effects of environmental and pharmacologically induced manipulation of acid–base status on cerebral blood flow regulation in healthy human participants.…”

Section: Background Physiologymentioning

confidence: 99%

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Lessons from on high: arterial CO₂, not pH, is the key mediator of cerebrovascular function

Leacy

2021

The Journal of Physiology

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Section: Discussion and Future Considerationsmentioning

confidence: 99%

“…The technically elegant study by Caldwell et al . (2021 b ) provides insight into the interaction between acid–base physiology and cerebrovascular regulation, showcasing

P_{aC O_{2}}

as a key mediator in CBF regulation.…”

Section: Background Physiologymentioning

confidence: 99%

See 1 more Smart Citation

Lessons from on high: arterial CO₂, not pH, is the key mediator of cerebrovascular function

Leacy

2021

The Journal of Physiology

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“…1977 a , 1977 b ; Caldwell et al . 2021 b , 2021 c ). Overall, CBF regulation is dependent on VSMC intracellular [H + ], which is directly affected by extracellular/perivascular pH, and its relationship to

P_{aC O_{2}}

such that

P_{aC O_{2}}

‐dependent changes in pH predicate cerebrovascular reactivity to CO 2 (Ainslie & Duffin, 2009; Hoiland et al .…”

Section: Introduction To Acid–base Physiologymentioning

confidence: 99%

“…Data from Caldwell et al . (2021 b ) (2021 c ). B , regulation of CBF is affected by the severity of chronic metabolic/respiratory disturbances and extent of subsequent respiratory/renal compensation (e.g.…”

Section: Introduction To Acid–base Physiologymentioning

confidence: 99%

Acid–base balance and cerebrovascular regulation

Caldwell

Carr

Minhas

et al. 2021

The Journal of Physiology

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The regulation and defence of intracellular pH is essential for homeostasis. Indeed, alterations in cerebrovascular acid–base balance directly affect cerebral blood flow (CBF) which has implications for human health and disease. For example, changes in CBF regulation during acid–base disturbances are evident in conditions such as chronic obstructive pulmonary disease and diabetic ketoacidosis. The classic experimental studies from the past 75+ years are utilized to describe the integrative relationships between CBF, carbon dioxide tension (PCO2), bicarbonate (HCO3–) and pH. These factors interact to influence (1) the time course of acid–base compensatory changes and the respective cerebrovascular responses (due to rapid exchange kinetics between arterial blood, extracellular fluid and intracellular brain tissue). We propose that alterations in arterial [HCO3–] during acute respiratory acidosis/alkalosis contribute to cerebrovascular acid–base regulation; and (2) the regulation of CBF by direct changes in arterial vs. extravascular/interstitial PCO2 and pH – the latter recognized as the proximal compartment which alters vascular smooth muscle cell regulation of CBF. Taken together, these results substantiate two key ideas: first, that the regulation of CBF is affected by the severity of metabolic/respiratory disturbances, including the extent of partial/full acid–base compensation; and second, that the regulation of CBF is independent of arterial pH and that diffusion of CO2 across the blood–brain barrier is integral to altering perivascular extracellular pH. Overall, by realizing the integrative relationships between CBF, PCO2, HCO3– and pH, experimental studies may provide insights to improve CBF regulation in clinical practice with treatment of systemic acid–base disorders.

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Dynamic cerebral blood flow changes with FOXOs stimulation are involved in neuronal damage associated with high-altitude cerebral edema in mice

Shi

Li²,

Zhou³

et al. 2022

Brain Research

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Regulation of cerebral blood flow by arterial PCO₂ independent of metabolic acidosis at 5050 m

Abstract: support-information-section).

Cited by 7 publications

References 102 publications

Lessons from on high: arterial CO₂, not pH, is the key mediator of cerebrovascular function

Lessons from on high: arterial CO₂, not pH, is the key mediator of cerebrovascular function

Acid–base balance and cerebrovascular regulation

Dynamic cerebral blood flow changes with FOXOs stimulation are involved in neuronal damage associated with high-altitude cerebral edema in mice

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Regulation of cerebral blood flow by arterial PCO2 independent of metabolic acidosis at 5050 m

Abstract: support-information-section).

Cited by 7 publications

References 102 publications

Lessons from on high: arterial CO2, not pH, is the key mediator of cerebrovascular function

Lessons from on high: arterial CO2, not pH, is the key mediator of cerebrovascular function

Acid–base balance and cerebrovascular regulation

Dynamic cerebral blood flow changes with FOXOs stimulation are involved in neuronal damage associated with high-altitude cerebral edema in mice

Contact Info

Product

Resources

About

Regulation of cerebral blood flow by arterial PCO₂ independent of metabolic acidosis at 5050 m

Lessons from on high: arterial CO₂, not pH, is the key mediator of cerebrovascular function

Lessons from on high: arterial CO₂, not pH, is the key mediator of cerebrovascular function