Regulation of chicken apolipoprotein B: cloning, tissue distribution, and estrogen induction of mRNA

Kirchgessner, Todd G.; Heinzmann, C.; Svenson, Karen L.; Gordon, David; Nicosia, Monica; Lebherz, Herbert G.; Lusis, Aldons J.; Williams, David L.

doi:10.1016/0378-1119(87)90332-5

Cited by 82 publications

(49 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are three instances in i o where large increases in apo B mRNA are observed, such as reported here. These include a 6-fold increase in livers derived from humans with abetalipoproteinaemia [28], a 7-fold increase in rat intestine during development [29] and a 6-fold increase in livers of oestradiol-treated roosters [30]. The mechanism by which BHMT leads to increases in apo B-mRNA abundance and apo B secretion remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase

Sowden

Collins

Smith

et al. 1999

Biochemical Journal

View full text Add to dashboard Cite

The cDNA encoding rat betaine-homocysteine S-methyltransferase (BHMT) was isolated through production of monoclonal antibodies against protein fractions enriched with apolipoprotein B (apo B)-mRNA-editing complexes. BHMT mRNA was expressed predominantly in liver, and also in kidney, but not in small intestine. In stable McArdle RH-7777 (McA) cell lines expressing differing levels of BHMT, the editing efficiency of apo B mRNA was unchanged. Evaluation of apo B-mRNA expression revealed that steady-state levels were increased significantly and in parallel with BHMT protein expression. The highest levels of BHMT mRNA and BHMT enzyme activity expressed in stably transfected McA cells were comparable with

show abstract

Section: Discussionmentioning

confidence: 99%

Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase

Sowden

Collins

Smith

et al. 1999

Biochemical Journal

View full text Add to dashboard Cite

show abstract

“…VLDLy has two associated apolipoproteins, apolipoprotein B (apoB) and apolipoprotein VLDL-II (apoVLDL-II), which are involved in the assembly of TG-rich lipoprotein particles. Avian apoB is a component of specialized VLDL particles that are produced by the liver in response to estrogen ( 8 ). apoVLDL-II mRNA was specifi cally expressed in the liver and upregulated after laying ( 9,10 ).…”

Section: Methodsmentioning

confidence: 99%

“…Estrogen is recognized as playing the primary role in the conversion of carbohydrate to TG and in the production of apoB and apoVLDL-II, leading to the hypersecretion of these lipoproteins into the circulation ( 8,66 ). ApoVLDL-II and apoB were shown to be rapidly induced by exogenous estrogen in the rooster liver and to accumulate within the VLDL fraction ( 67 ).…”

Section: Gc-induced Decrease In Estrogen Level Is Energy Dependentmentioning

confidence: 99%

Corticosterone regulation of ovarian follicular development is dependent on the energy status of laying hens

Wang¹,

Li²,

Song³

et al. 2013

Journal of Lipid Research

View full text Add to dashboard Cite

This article is available online at http://www.jlr.org secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus stimulates the release of the pituitary gonadotropins, luteinizing hormone (LH), and folliclestimulating hormone (FSH), which in turn activate gonadal development and release of sex steroids, including estradiol (E2) and testosterone. Stress is a common problem disrupting breeding in either wild birds or domestic chickens ( 1 ). Glucocorticoids (GC), as the fi nal effectors of the hypothalamic-pituitary-adrenal axis, participate in the control of whole body homeostasis and the arousal of stress responses. GCs transmit information about environmental conditions to the HPG axis, which ultimately infl uences the timing of breeding.Female kittiwakes with low baseline LH levels and elevated levels of baseline corticosterone (CORT), the main form of GCs in avians, were more likely to skip breeding ( 2 ). An experimental reduction of CORT release during the prelaying period was associated with an advancement of egg laying in female kittiwakes ( 3 ). In domestic chickens, an acute infusion of CORT resulted in a pause in laying and a severely reduced ovarian weight ( 4 ). Chronic and repeated exposure to CORT during the rearing phrase suppressed reproductive performance, resulting in a delay of fi rst egg laid and a reduction of egg production ( 5 ).In avians, the development of ovarian follicles is accompanied by the deposition of a large amount of yolk. During a laying cycle, follicular development is matched with a supply of yolk precursors. Triacylglycerols (TG), the main

show abstract

“…Three of these clones (KcV1-36, ~cV3-38, and ~cAB-11) were plaque purified, and the inserts (0.9, 0.65, and 0.7 kb, respectively) were subcloned in both orientations into the EcoRI site of the plasmid vector SP65 for further analysis. The KcAB-11 clone was identified as coding for a portion of the apoB gene (Kirchgessner et al 1987;T. Kirchgessner, pers.…”

Section: The Isolation Of Chicken Vtgi and Vtgiii Clones From A Cdna mentioning

confidence: 99%

“…A fifth gene that contributes protein to the egg yolk is constitutively expressed in chickens of both sexes and codes for a protein, apolipoprotein B (apoB), that also serves as a component of circulating very-low-density and low-density lipoprotein particles (Evans and Burley 1987). The level of apoB RNA in the liver is increased about sixfold following the administration of estrogen (Kirchgessner et al 1987).…”

mentioning

confidence: 99%

Isolation of chicken vitellogenin I and III cDNAs and the developmental regulation of five estrogen-responsive genes in the embryonic liver.

Evans¹,

Silva²,

Burch³

1988

Genes Dev.

View full text Add to dashboard Cite

The isolation of cDNA clones that code for portions of the two minor chicken vitellogenin (VTG) genes (VTGI and VTGIII) is reported. These clones represent unique sequences that are expressed exclusively in the livers of estrogenized birds. In the liver of the egg-laying hen, the levels of RNAs encoding VTGI, VTGII, and VTGIII are approximately 11,000, 30,000, and 3,000 molecules per cell, respectively. We have used the newly isolated clones, as well as the yolk protein cDNAs previously available [VTGII, apolipoprotein II (apoVLDLII), and apolipoprotein B], as probes to examine several aspects of the regulation of these genes by estradiol. First, we demonstrate that the capacity of each gene to respond to estradiol is acquired between 8 and 13 days in ovo. The response of four of these genes to estradiol is diminshed during late fetal development, but the responsiveness is recovered within a week after hatching. Second, we demonstrate that these genes display distinct kinetic response profiles following the addition of estradiol. Third, as has been described previously for the VTGII and apoVLDLII genes, we demonstrate that a single injection of estradiol effects a long-term reprogramming event (hepatic memory) that allows a faster onset of the rapid accumulation of both VTGI and VTGIII RNAs following a subsequent rechallenge by estradiol. Collectively, these three sets of data suggest molecular parameters that may contribute to both the coordinate and noncoordinate regulation of this set of genes by estradiol.

show abstract

Regulation of chicken apolipoprotein B: cloning, tissue distribution, and estrogen induction of mRNA

Cited by 82 publications

References 31 publications

Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase

Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase

Corticosterone regulation of ovarian follicular development is dependent on the energy status of laying hens

Isolation of chicken vitellogenin I and III cDNAs and the developmental regulation of five estrogen-responsive genes in the embryonic liver.

Contact Info

Product

Resources

About