2015
DOI: 10.1073/pnas.1511448112
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Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance

Abstract: Inheritance of the callipyge phenotype in sheep is an example of polar overdominance inheritance, an unusual mode of inheritance. To investigate the underlying molecular mechanism, we profiled the expression of the genes located in the Delta-like 1 homolog (Dlk1)-type III iodothyronine deiodinase (Dio3) imprinting region in mice. We found that the transcripts of the microRNA (miR) 379/miR-544 cluster were highly expressed in neonatal muscle and paralleled the expression of the Dlk1. We then determined the in v… Show more

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Cited by 40 publications
(42 citation statements)
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“…We then further measured the primary transcript levels of the miR‐379/miR‐544 cluster in postnatal developing testes and observed the miR‐379/miR‐544 cluster primary transcripts displayed a gradually declining expression pattern from postnatal 0 (P0) to P42 testis, and the highest expression levels were detected at P0 and lowest detectable expression was observed at P28 testis (Figure d–e). This dynamic expression pattern in testis was similar to that reported for the miR‐379/miR‐544 cluster in skeletal muscle (Gao et al, ). Given that, we hypothesize that the miR‐379/miR‐544 cluster may be involved in the first wave of spermatogenesis and testicular development.…”
supporting
confidence: 87%
See 1 more Smart Citation
“…We then further measured the primary transcript levels of the miR‐379/miR‐544 cluster in postnatal developing testes and observed the miR‐379/miR‐544 cluster primary transcripts displayed a gradually declining expression pattern from postnatal 0 (P0) to P42 testis, and the highest expression levels were detected at P0 and lowest detectable expression was observed at P28 testis (Figure d–e). This dynamic expression pattern in testis was similar to that reported for the miR‐379/miR‐544 cluster in skeletal muscle (Gao et al, ). Given that, we hypothesize that the miR‐379/miR‐544 cluster may be involved in the first wave of spermatogenesis and testicular development.…”
supporting
confidence: 87%
“…A cluster of imprinted miRNAs encoded by imprinted Dlk1–Dio3 locus were reported to be high expressed in ES cells and 4n‐iPS cells and correlated with the pluripotency levels of mouse stem cells (Liu et al, ). The primary transcript of miR‐379/miR‐544 cluster was enriched in embryonic and perinatal skeletal muscle, and is associated with callipyge phenotype in young animals (Gao et al, ). However, whether the miR‐379/miR‐544 cluster at imprinted Dlk1–Dio3 region contributes to testicular development and spermatogenesis remains elusive.…”
mentioning
confidence: 99%
“…Moreover, this miRNA cluster on the mouse distal chromosome 12 was down-regulated in mouse skeletal muscles due to aging [46]. Recently, deletion of the maternally expressed miR-379/miR-544 cluster that is highly expressed in embryonic and neonatal stages, led to fast-twitch muscle hypertrophy via regulation of DLK1 expression in mice [47]. Therefore, this miRNA cluster might play fundamental roles during muscle development in a yet unknown way.…”
Section: Discussionmentioning
confidence: 99%
“…It has been speculated that Dlk1 expression is regulated by noncoding RNA genes or microRNA clusters through posttranscriptional trans inhibition [26,46]. Alternatively, its expression may be regulated in a manner analogous to the IMP protein binding to both IGF2 and H19 transcripts [47].…”
Section: Discussionmentioning
confidence: 99%