Regulation of Drosophila life-span: Effect of genetic background, sex, mating and social status

Iliadi, Konstantin G.; Iliadi, Natalia; Boulianne, Gabrielle L.

doi:10.1016/j.exger.2009.05.008

Cited by 30 publications

(45 citation statements)

References 39 publications

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“…Nevertheless, this does not exclude the possibility of the contribution of variants at nuclear genes as well. As expected, virgin females live longer than males (Iliadi et al 2009). …”

Section: Discussionsupporting

confidence: 81%

Drosophila americana as a Model Species for Comparative Studies on the Molecular Basis of Phenotypic Variation

Fonseca

Morales‐Hojas

Reis

et al. 2013

Genome Biology and Evolution

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Understanding the molecular basis of within and between species phenotypic variation is one of the main goals of Biology. In Drosophila, most of the work regarding this issue has been performed in D. melanogaster, but other distantly related species must also be studied to verify the generality of the findings obtained for this species. Here, we make the case for D. americana, a species of the virilis group of Drosophila that has been diverging from the model species, D. melanogaster, for approximately 40 Myr. To determine the suitability of this species for such studies, polymorphism and recombination estimates are presented for D. americana based on the largest nucleotide sequence polymorphism data set so far analyzed (more than 100 data sets) for this species. The polymorphism estimates are also compared with those obtained from the comparison of the genome assembly of two D. americana strains (H5 and W11) here reported. As an example of the general utility of these resources, we perform a preliminary study on the molecular basis of lifespan differences in D. americana. First, we show that there are lifespan differences between D. americana populations from different regions of the distribution range. Then, we perform five F2 association experiments using markers for 21 candidate genes previously identified in D. melanogaster. Significant associations are found between polymorphism at two genes (hep and Lim3) and lifespan. For the F2 association study involving the two sequenced strains (H5 and W11), we identify amino acid differences at Lim3 and Hep that could be responsible for the observed changes in lifespan. For both genes, no large gene expression differences were observed between the two strains.

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“…Nevertheless, this does not exclude the possibility of the contribution of variants at nuclear genes as well. As expected, virgin females live longer than males (Iliadi et al 2009). …”

Section: Discussionsupporting

confidence: 81%

Drosophila americana as a Model Species for Comparative Studies on the Molecular Basis of Phenotypic Variation

Fonseca

Morales‐Hojas

Reis

et al. 2013

Genome Biology and Evolution

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“…It is not surprising that sex influences the lifespan extending effect of hormesis in insects as longevity in males and females respond differently to most genetic or environmental interventions (see, e.g. Maklakov et al 2008Maklakov et al , 2009Bilde et al 2009;Iliadi et al 2009;Tricoire et al 2009) and is even reported to respond differently to clinal selection in the wild (Norry et al 2006). However, in some experiments the hormesis phenomenon has been documented in both sexes (Le Bourg et al 2001;Hercus et al 2003).…”

Section: Introductionmentioning

confidence: 92%

Life extension and the position of the hormetic zone depends on sex and genetic background in Drosophila melanogaster

Sarup

Loeschcke

2010

Biogerontology

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Hormesis, the beneficial effect of a mild stress, has been proposed as a means to prolong the period of healthy ageing as it can increase the average lifespan of a cohort. However, if we want to use hormesis therapeutically it is important that the treatment is beneficial on the individual level and not just on average at the population level. Long lived lines have been shown not to benefit from a, in other lines, hormesis inducing heat treatment in Drosophila melanogaster, D. buzzatii and mice. Also in many experiments hormesis has been reported to occur in one sex only, usually males but not in females. Here we investigated the interaction between the hormetic response and genetic background, sex and duration of a mild heat stress in D. melanogaster, using three replicate lines that have been selected for increased longevity and their respective control lines. We found that genetic background influences the position of the hormetic zone. The implication of this result could be that in a genetically diverse populations a treatment that is life prolonging in one individual could be life shortening in other individuals. However, we did find a hormetic response in all combinations of line and sex in at least one of the experiments which suggests that if it is possible to identify the optimal hormetic dose individually hormesis might become a therapeutic treatment.

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“…Reproduction, for instance, is known to be life-shortening in females of a number of species (de Heij et al, 2006; Liker and Szekely, 2005). However, it can also be costly in males, particularly if one includes the cost of male competition (Iliadi et al, 2009; Nussey et al, 2009). Therefore, it is always wise to question whether sex differences in longevity observed in wild population reflect intrinsic differences in the rate of physiological senescence or not.…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in Lifespan

2016

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SUMMARY Sex differences in longevity can provide insights into novel mechanisms of aging, yet they have been little studied. Surprisingly, sex-specific longevity patterns are better known in wild animals. Evolutionary hypotheses accounting for longevity patterns in natural populations include differential vulnerability to environmental hazards, differential intensity of sexual selection and distinct patterns of parental care. Mechanistic hypotheses focus on asymmetric inheritance of sex chromosomes and mitochondria. Virtually all intensively studied species show conditional sex differences in longevity. Humans are the only species in which one sex is known to have a ubiquitous survival advantage. Paradoxically, although women live longer, they suffer greater morbidity particularly late in life. This mortality-morbidity paradox may be a consequence of greater connective tissue responsiveness to sex hormones in women. Human females’ longevity advantage may result from hormonal influences on inflammatory and immunological responses, or greater resistance to oxidative damage; current support for these mechanisms is weak.

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Regulation of Drosophila life-span: Effect of genetic background, sex, mating and social status

Cited by 30 publications

References 39 publications

Drosophila americana as a Model Species for Comparative Studies on the Molecular Basis of Phenotypic Variation

Drosophila americana as a Model Species for Comparative Studies on the Molecular Basis of Phenotypic Variation

Life extension and the position of the hormetic zone depends on sex and genetic background in Drosophila melanogaster

Sex Differences in Lifespan

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