2018
DOI: 10.1101/340356
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Regulation of EGFR endocytosis by CBL during mitosis

Abstract: Endocytosis plays important roles in regulating EGFR signaling. We previously found that EGFR endocytosis during mitosis is mediated differently than during interphase. While the regulation of EGFR endocytosis in interphase is well understood, little is known regarding the regulation of EGFR endocytosis during mitosis. Here, we studied the mechanisms regulating mitotic EGFR endocytosis. We found that contrary to interphase cells, mitotic EGFR endocytosis is more reliant on the activation of the E3 ligase CBL. … Show more

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Cited by 3 publications
(1 citation statement)
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“…Interestingly, a strong correlation was observed over the internalization of three endocytic Rdots, likely due to that they are probing the same class of biological process. The expression of transmembrane receptor EGFR is positively correlated with endocytic channels, which is reasonable since endocytosis plays an important role in EGFRmediated cell signaling 80 .…”
Section: Resultsmentioning
confidence: 62%
“…Interestingly, a strong correlation was observed over the internalization of three endocytic Rdots, likely due to that they are probing the same class of biological process. The expression of transmembrane receptor EGFR is positively correlated with endocytic channels, which is reasonable since endocytosis plays an important role in EGFRmediated cell signaling 80 .…”
Section: Resultsmentioning
confidence: 62%