2015
DOI: 10.1016/j.neuroscience.2015.10.056
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Regulation of electrical activity and neuronal excitability in Helisoma trivolvis by carbon monoxide

Abstract: Carbon monoxide (CO), like other gaseous neuromodulators, has a dual nature as both a toxic gas and a physiologically relevant signaling molecule. In the nervous system, high concentrations of CO can lead to neuronal injury while lower concentrations are found to be neuroprotective. The number of cellular targets affected by physiological concentrations of CO is rapidly growing and includes ion channels in various cell types. The modulation of ion channels by CO in neurons, however, and the effect it has on ne… Show more

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Cited by 2 publications
(2 citation statements)
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“…To test for the direct effects of CO on filopodia and exclude the effects of its endogenously produced co‐byproducts biliverdin and ferrous iron, we bath applied the CO‐donor carbon monoxide releasing molecule‐2 (CORM‐2; 50 µ M ) to developing B5 and B19 neurons in vitro . While there are no measurements of the amount of CO produced within the snail nervous system, the CO concentration used here has been shown to produce physiological effects similar to the induction of the HO pathway in other species (Knipp and Bicker, ; Scheiblich and Bicker, ) and is known to affect the electrical activity of developing B5 and B19 neurons (Estes et al, ). Addition of CORM‐2 (50 µ M ) to the culture dish resulted in a significant increase in filopodial length in both B5 and B19 neurons over time [Fig.…”
Section: Resultsmentioning
confidence: 99%
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“…To test for the direct effects of CO on filopodia and exclude the effects of its endogenously produced co‐byproducts biliverdin and ferrous iron, we bath applied the CO‐donor carbon monoxide releasing molecule‐2 (CORM‐2; 50 µ M ) to developing B5 and B19 neurons in vitro . While there are no measurements of the amount of CO produced within the snail nervous system, the CO concentration used here has been shown to produce physiological effects similar to the induction of the HO pathway in other species (Knipp and Bicker, ; Scheiblich and Bicker, ) and is known to affect the electrical activity of developing B5 and B19 neurons (Estes et al, ). Addition of CORM‐2 (50 µ M ) to the culture dish resulted in a significant increase in filopodial length in both B5 and B19 neurons over time [Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Similar to effects reported for stimulation with NO, the inhibition of RyRs using dantrolene or ryanodine also prevented the CO‐mediated change in filopodial length; however, unlike NO, CO did not increase growth cone calcium levels but rather decreased it. With a number of studies showing that electrical activity is highly correlated with growth cone calcium levels (Bolsover and Spector, ; Ross et al, ; Torreano and Cohan, ; Kuznetsov et al, ; Estes et al, ) and that CO silences spontaneous firing activity (Estes et al, ), it was not surprising that CO decreased the overall growth cone calcium level. Interestingly, however, the CO‐induced increase in filopodial length occurred while bulk calcium levels were low.…”
Section: Discussionmentioning
confidence: 99%