Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects

Hussain, Yaseen; Khan, Haroon; Efferth, Thomas; Alam, Waqas

doi:10.1016/j.phymed.2022.153985

Cited by 16 publications

(3 citation statements)

References 177 publications

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“…It prevents the uptake of glucose by different cancer cell lines, lowers NF-қB activity, which slows the growth of tumours, and improves lethality by causing the production of intracellular ROS. [105] In another investigation, hesperetin was found to enhance the anticancer medication cisplatin's activity in the treatment of pulmonary cancer. Hesperetin was shown to suppress the multidrug resistance protein, which has been linked to the tolerance to cisplatin that has evolved in a significant percentage of patients receiving cancer treatment.…”

Section: Flavanonesmentioning

confidence: 99%

Role of Polyphenols and Flavonoids as Anti-Cancer Drug Candidates: A Review

Hegde¹,

Lakshman²

2023

Pharmacogn. Res.

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Natural drug-based chemotherapeutic have advanced at an unprecedented rate over the past decade. Owing to protective roles in vegetation, and exceptional antioxidant qualities, polyphenols and flavonoids have demonstrated promising clinical implications in malignancies amongst other plant metabolites. It is widely debated how dietary flavonoids and polyphenols can prevent cancer. Flavonoids are believed to execute a significant role in cancer prevention and treatment, as corroborated from experimental studies, epidemiological research, and human clinical trials. Carcinogen deactivation, antimutagenic, cell cycle arrest, apoptosis and differentiation, suppression of vasculature, oxidative stress, and reversion of multidrug resistance are among the many mechanisms of action that have been discovered. The present review outlines the classification of various polyphenols and flavonoids and their potential as anticancer therapeutic agents.

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Section: Flavanonesmentioning

confidence: 99%

Role of Polyphenols and Flavonoids as Anti-Cancer Drug Candidates: A Review

Hegde¹,

Lakshman²

2023

Pharmacogn. Res.

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“…In recent years, extracellular vesicle-like nanoparticles (EVNs) have been isolated from the fresh juice of various edible plants. , EVNs are composed of lipids, proteins, nucleic acids, and other components, which can be delivered into recipient cells to induce cross-species interference. , However, it is not clear whether lemon-derived EVNs (LEVNs) also have the same or even better effects as CA alone and, if so, how such EVNs work. Cumulative data indicate that exposure of the CaOx crystal induces endoplasmic reticulum (ER) stress response of RTECs, which is manifested by increased cytoplasmic Ca 2+ signal and expression of glucose-regulated protein78/immunoglobulin binding protein (GRP78/BIP) and C/EBP homologous protein (CHOP). − Mitochondria help buffer transient Ca 2+ elevations, but overloaded ER-to-mitochondria Ca 2+ transfer leads to mitochondrial damage and cell apoptosis. , Previous results indicated citrus-derived compounds could inhibit ER stress. , However, it remains vague whether LEVNs interfere with kidney stones by dominating ER stress suppression.…”

Section: Purification Characterization and Composition Analysis Of Levnsmentioning

confidence: 99%

Lemon-Derived Extracellular Vesicle-like Nanoparticles Block the Progression of Kidney Stones by Antagonizing Endoplasmic Reticulum Stress in Renal Tubular Cells

Zhang

Cong

et al. 2023

Nano Lett.

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Kidney stones, represented by the calcium oxalate (CaOx) type, are highly prevalent and recrudescent. Cumulative evidence shows regular consumption of lemonade intervenes with stone development. However, the detailed mechanism remains obscure. Here, extracellular vesicle-like nanoparticles (LEVNs) isolated from lemonade are demonstrated to traffick from the gut to the kidney, primarily enriched in tubule cells. Oral administration of LEVNs significantly alleviates the progression of kidney stones in rats. Mechanistically, in addition to altering the crystallization of CaOx toward a less stable subtype, LEVNs suppress the CaOx-induced endoplasmic reticulum stress response of tubule cells, as indicated by homeostasis of specific signaling molecules and restoration of subcellular function, thus indirectly inhibiting stone formation. To exercise this regulation, endocytosed LEVNs traffick along the microtubules throughout the cytoplasm and are eventually recruited into lysosomes. In conclusion, this study reveals a LEVNs-mediated mechanism against renal calculi and provides positive evidence for consumption of lemonade preventing stone formation.

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“…Severe diarrhea can cause dehydration, electrolyte imbalance, and nutritional deficiency, which are associated with premature death in 5% of cancer patients [ 120 ]. Hesperidin is a natural flavonoid widely found in fruits and flowers, with a variety of pharmacological activities such as anti-inflammatory, antioxidant, cardiovascular protection, and antitumor [ 121 ]. Oral administration of hesperidin 20 mg/kg and 100 mg/kg significantly reduced irinotecan-induced diarrhea in CT-26 tumor-bearing immune mice and reduced the risk of severe diarrhea.…”

Section: Natural Compounds That Attenuate Adverse Effects Of Chemothe...mentioning

confidence: 99%

Exploration of the Use of Natural Compounds in Combination with Chemotherapy Drugs for Tumor Treatment

et al. 2023

Molecules

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Currently, chemotherapy is the main treatment for tumors, but there are still problems such as unsatisfactory chemotherapy results, susceptibility to drug resistance, and serious adverse effects. Natural compounds have numerous pharmacological activities which are important sources of drug discovery for tumor treatment. The combination of chemotherapeutic drugs and natural compounds is gradually becoming an important strategy and development direction for tumor treatment. In this paper, we described the role of natural compounds in combination with chemotherapeutic drugs in synergizing, reducing drug resistance, mitigating adverse effects and related mechanisms, and providing new insights for future oncology research.

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Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects

Cited by 16 publications

References 177 publications

Role of Polyphenols and Flavonoids as Anti-Cancer Drug Candidates: A Review

Role of Polyphenols and Flavonoids as Anti-Cancer Drug Candidates: A Review

Lemon-Derived Extracellular Vesicle-like Nanoparticles Block the Progression of Kidney Stones by Antagonizing Endoplasmic Reticulum Stress in Renal Tubular Cells

Exploration of the Use of Natural Compounds in Combination with Chemotherapy Drugs for Tumor Treatment

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