Regulation of Erythropoiesis. XV. Neonatal Erythropoiesis and the Effect of Nephrectomy *

Lucarelli, G; Howard, Donald; Stohlman, Frederick

doi:10.1172/jci105093

Cited by 64 publications

(19 citation statements)

References 16 publications

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“…Moreover, it is not known whether the processes leading to this change are initiated in utero or postpartum. Both possibilities find support in previously published findings (5,14). In rats, the liver continues to function as the primary site of Ep formation at birth and for a time thereafter (14) leaving open the possibility that the initiation of the switch could occur before or after birth.…”

Section: Discussionsupporting

confidence: 78%

“…Both possibilities find support in previously published findings (5,14). In rats, the liver continues to function as the primary site of Ep formation at birth and for a time thereafter (14) leaving open the possibility that the initiation of the switch could occur before or after birth. On the other hand, studies by Lucarelli et al (5) in guinea pigs suggest that the process may have been initiated in utero.…”

Section: Discussionsupporting

confidence: 78%

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Studies on the Liver to Kidney Switch of Erythropoietin Production

Zanjani¹,

Ascensāo²,

McGlave³

et al. 1981

J. Clin. Invest.

165

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A B S T R A C T Although the liver is the major site of erythropoietin (Ep) production in the fetus, this function is assumed by kidneys in the adult. The mechanisms underlying the liver to kidney switch of Ep formation are not understood. We studied the natural progression ofthis transition in sheep by measuring Ep production in response to anemia in normal and bilaterally nephrectomized fetal and newborn sheep beginning at about 80 d gestation (normal gestation: 140 d). Removal of both kidneys before induction of anemia did not affect Ep formation up to about 120 d of gestation. A significant reduction (29%, P < 0.02) in Ep synthesis was first noted at about 130 d of gestation (initiation of switch). This level of nephrectomyinduced reduction of Ep formation persisted until about 15 d after birth. Thereafter, bilateral nephrectomy caused further significant decreases (P < 0.05) in Ep production, gradually resulting in near total absence of Ep production at about day 40 postpartum (completion of switch). Chronic administration of testosterone (12 mg/wk) or estradiole benzoate (1.5 mg/d, 5 d/wk) to the fetus/newborn beginning at 85-90 d of gestation enhanced or suppressed erythropoiesis, respectively, but failed to affect the time at which the liver to kidney switch was initiated and/or completed. By contrast, a significant delay (P < 0.001) in the onset, but not completion of the switch occurred in animals that were either thyroidectomized or rendered chronically anemic beginning in the second third of the gestation period. Administration ofthyroxin (1.2 mg/d, 5 d/wk) to thyroidectomized fetus/newborns not only prevented the delay in the initiation of the switch, but also accelerated the rate at which the switch was completed. These results demonstrate that in sheep (a) the liver to kidney switch of Ep production is initiated in utero during the last third of the gestation period, but is Address reprint requests

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Section: Discussionsupporting

confidence: 78%

Section: Discussionsupporting

confidence: 78%

Studies on the Liver to Kidney Switch of Erythropoietin Production

Zanjani¹,

Ascensāo²,

McGlave³

et al. 1981

J. Clin. Invest.

165

View full text Add to dashboard Cite

show abstract

“…The most important extrarenal source of Ep in the adult is the liver (5). By contrast, the liver represents the primary source of Ep during fetal and early neonatal periods (6,7). The production of Ep by the liver in the fetus-newborn is regulated by mechanisms similar to those that control renal Ep production in the adult (6,7).…”

Section: Introductionmentioning

confidence: 99%

“…By contrast, the liver represents the primary source of Ep during fetal and early neonatal periods (6,7). The production of Ep by the liver in the fetus-newborn is regulated by mechanisms similar to those that control renal Ep production in the adult (6,7). Thus hypoxia represents the fundamental erythropoietic stimulus for both organs (7).…”

Section: Introductionmentioning

confidence: 99%

“…The production of Ep by the liver in the fetus-newborn is regulated by mechanisms similar to those that control renal Ep production in the adult (6,7). Thus hypoxia represents the fundamental erythropoietic stimulus for both organs (7). The switch from hepatic to renal production of Ep, which occurs soon after birth, is accompanied by the effective loss of hepatic Ep formation.…”

Section: Introductionmentioning

confidence: 99%

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Hormonal stimulation of erythropoietin production and erythropoiesis in anephric sheep fetuses.

Zanjani¹,

Banisadre²

1979

J. Clin. Invest.

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A B S T R A C T The effect of testosterone (DT) and thyroxin (L-T4) on erythropoiesis and erythropoietin (Ep) These data demonstrate that (a) DT aind L-T4 are effective promnoters of extrarenal Ep production, thereby enhancing erythropoiesis in intact and nephrectomized fetuses; (b) DT is a stronger stimulus of extrarenal Ep formation than L-T4; and (c) Ep is required for the expression of the erythropoietic effects of L-T4 and DT.

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Regulation of Fetal and Adult Erythropoiesis

Peschle

Condorelli

1976

Ciba Foundation Symposium 37 ‐ Congenital Disorders of Erythropoiesis

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Regulation of Erythropoiesis. XV. Neonatal Erythropoiesis and the Effect of Nephrectomy *

Cited by 64 publications

References 16 publications

Studies on the Liver to Kidney Switch of Erythropoietin Production

Studies on the Liver to Kidney Switch of Erythropoietin Production

Hormonal stimulation of erythropoietin production and erythropoiesis in anephric sheep fetuses.

Regulation of Fetal and Adult Erythropoiesis

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