Regulation of Erythropoietin Production

Fisher, James W.

doi:10.1002/cphy.cp080251

Cited by 2 publications

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“…Therefore, in a similar experimental design using theophylline and dipyridamole There is some evidence from in vitro and animal experiments for the assumption that adenosine (ADO) might modulate treatment, EPO production was stimulated by hypobaric hypoxia by subjecting healthy volunteers to a simulated renal erythropoietin (EPO) production [1]. According to this hypothesis, increasing renal ADO levels (e.g.…”

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confidence: 99%

Erythropoietin production in healthy volunteers subjected to controlled hypobaric hypoxia: further evidence against a role for adenosine

Gleiter¹,

T²,

Wenzel

1997

Brit J Clinical Pharma

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Aims Objective of this study was to investigate whether adenosine modulates renal erythropoietin production. Methods In the present study erythropoietin production was stimulated by hypobaric hypoxia by subjecting healthy volunteers to a simulated altitude of 4000 m in a low pressure chamber for 5.5 h. During exposure to hypoxia the subjects received i.v. in a randomized, single-blind, cross-over fashion the non-specific adenosine antagonist theophylline, the adenosine reuptake inhibitor dipyridamole and placebo. Results Contrary to the working hypothesis, theophylline did not decrease and dipyridamole did not further boost erythropoietin concentrations. Conclusions The results are in agreement with our earlier study using haemorrhage as a controlled physiological stimulus of erythropoietin production, and would question a major role for adenosine as a mediator of renal erythropoietin production.

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confidence: 99%

Erythropoietin production in healthy volunteers subjected to controlled hypobaric hypoxia: further evidence against a role for adenosine

Gleiter¹,

T²,

Wenzel

1997

Brit J Clinical Pharma

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“…Erythropoietin, a glycoprotein hormone, is the primary regulator of erythrocyte formation in bone marrow and extramedullary sites 7 . Erythropoietin has been used extensively and successfully to treat anemia associated with end‐stage renal disease 8 .…”

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confidence: 99%

Avoiding Transfusion in Head and Neck Surgery: Feasibility Study of Erythropoietin

2000

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Objective: To determine the feasibility of perioperative erythropoietin to avoid blood transfusion in head and neck cancer surgery. Study Design: Retrospective chart review. Methods: Ninety-nine patients undergoing surgical resection of head and neck tumors at our institution were assessed for demographic data, nutritional parameters, tumor/surgical information, hematological/transfusion data, and contraindications to erythropoietin. Each transfusion was classified as to its appropriateness, and the potential benefit of erythropoietin was assessed in each patient. A cost analysis was also performed. Results: Most transfused patients (63%) received too many units. A subgroup at high risk of transfusion was identified who would benefit most from perioperative erythropoietin. Assuming that perioperative erythropoietin therapy is equivalent to the transfusion of 4 units, we estimate that the majority (74%) of transfused patients would not have required a transfusion if more stringent transfusion criteria were followed and those at high risk were given perioperative erythropoietin. Although the cost for transfusing 4 units is equivalent to that of a perioperative course of erythropoietin, the overall direct cost of erythropoietin treatment would actually have been more expensive. Conclusions: Perioperative erythropoietin therapy may be appropriate for a subgroup of head and neck cancer patients, but a prospective randomized controlled study in such a subgroup is needed to better define those most likely to benefit from it and to assess actual cosUbenefit ratios.

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Regulation of Erythropoietin Production

Cited by 2 publications

References 223 publications

Erythropoietin production in healthy volunteers subjected to controlled hypobaric hypoxia: further evidence against a role for adenosine

Erythropoietin production in healthy volunteers subjected to controlled hypobaric hypoxia: further evidence against a role for adenosine

Avoiding Transfusion in Head and Neck Surgery: Feasibility Study of Erythropoietin

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