2023
DOI: 10.1111/adb.13349
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Regulation of ethanol‐mediated dopamine elevation by glycine receptors located on cholinergic interneurons in the nucleus accumbens

Anna Loftén,
Louise Adermark,
Mia Ericson
et al.

Abstract: Alcohol use disorder is one of the major psychiatric disorders worldwide, and there are many factors and effects contributing to the disorder, for example, the experience of ethanol reward. The rewarding and reinforcing properties of ethanol have been linked to activation of the mesolimbic dopamine system, an effect that appears to involve glycine receptors (GlyRs) in the nucleus accumbens. On which neuronal subtypes these receptors are located is, however, not known. The aim of this study was to explore the r… Show more

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Cited by 5 publications
(1 citation statement)
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“…EtOH consumption is also reduced by the nAChR partial agonist varenicline (Blomqvist et al, 1996;Ericson et al, 2009;Hendrickson et al, 2010;Steensland et al, 2007;Wouda et al, 2011), and these effects rely at least in part on cholinergic regulation of dopamine release in the NAc core (Feduccia et al, 2014;Nadal et al, 1998;Schilaty et al, 2014). CINs are the primary source of ACh in the striatum and ablation of these neurons reduced EtOH-induced increases in NAc dopamine (Loftén et al, 2023(Loftén et al, , 2021. Targeted excitation of NAc CINs has also been shown to increase EtOH consumption in mice (Kolpakova et al, 2022).…”
Section: Discussionmentioning
confidence: 99%
“…EtOH consumption is also reduced by the nAChR partial agonist varenicline (Blomqvist et al, 1996;Ericson et al, 2009;Hendrickson et al, 2010;Steensland et al, 2007;Wouda et al, 2011), and these effects rely at least in part on cholinergic regulation of dopamine release in the NAc core (Feduccia et al, 2014;Nadal et al, 1998;Schilaty et al, 2014). CINs are the primary source of ACh in the striatum and ablation of these neurons reduced EtOH-induced increases in NAc dopamine (Loftén et al, 2023(Loftén et al, , 2021. Targeted excitation of NAc CINs has also been shown to increase EtOH consumption in mice (Kolpakova et al, 2022).…”
Section: Discussionmentioning
confidence: 99%