2021
DOI: 10.21203/rs.3.rs-246143/v1
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Regulation of Exosome Secretion by Cellular Retinoic Acid Binding Protein 1 Contributes to Systemic Anti-inflammation

Abstract: Background: Intercellular communications are important for maintaining normal physiological processes. An important intercellular communication is mediated by the exchange of membrane-enclosed extracellular vesicles. Among various vesicles, exosomes can be detected in a wide variety of biological systems, but the regulation and biological implication of exosome secretion/uptake remains largely unclear.Methods: Cellular retinoic acid (RA) binding protein 1 (Crabp1) knockout (CKO) mice were used for in vivo stud… Show more

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“…While CRABP1 is strongly expressed during development [59], its expression in adult brain is restrained to very specific cell populations. Initially suggested to play roles in RA metabolism and RA-mediated gene expression [60,61], CRABP1 has recently been shown to interact and affect the phosphorylation of the calcium-calmodulindependent protein kinase II [62,63] and to modulate ERK signaling [64][65][66]. Together, this work suggests a potential role for hypothalamic CRABP1 in modulating intracellular signaling pathways involved in neuroplasticity and response to metabolic hormones.…”
Section: Discussionmentioning
confidence: 84%
“…While CRABP1 is strongly expressed during development [59], its expression in adult brain is restrained to very specific cell populations. Initially suggested to play roles in RA metabolism and RA-mediated gene expression [60,61], CRABP1 has recently been shown to interact and affect the phosphorylation of the calcium-calmodulindependent protein kinase II [62,63] and to modulate ERK signaling [64][65][66]. Together, this work suggests a potential role for hypothalamic CRABP1 in modulating intracellular signaling pathways involved in neuroplasticity and response to metabolic hormones.…”
Section: Discussionmentioning
confidence: 84%