Regulation of Expression of Keratins and their Pathogenic Roles in Keratinopathies

Komine, Mayumi

doi:10.5772/intechopen.79140

Cited by 6 publications

(6 citation statements)

References 28 publications

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“…In AD lesional skin, KRT6, KRT16 and KRT17 are highly expressed, while KRT1 and KRT10 are downregulated, 55,56 most likely due to suppression by IL-4 and IL-13. 57 In HE, we also found high expression It is well known that non-lesional AD skin significantly differs from healthy skin, including delayed and intermittent expression of barrier genes and their proteins (e.g.…”

Section: F I G U R E 1 Multivariate Gene Expression Analysis By Pcamentioning

confidence: 99%

Vesicular hand eczema transcriptome analysis provides insights into its pathophysiology

Voorberg

Niehues

Oosterhaven

et al. 2021

Experimental Dermatology

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Hand eczema is a common inflammatory skin condition of the hands whose pathogenesis is largely unknown. More insight and knowledge of the disease on a more fundamental level might lead to a better understanding of the biological processes involved, which could provide possible new treatment strategies. We aimed to profile the transcriptome of lesional palmar epidermal skin of patients suffering from vesicular hand eczema using RNA-sequencing. RNA-sequencing was performed to identify differentially expressed genes in lesional vs. non-lesional palmar epidermal skin from a group of patients with vesicular hand eczema compared to healthy controls.Comprehensive real-time quantitative PCR analyses and immunohistochemistry were used for validation of candidate genes and protein profiles for vesicular hand eczema.Overall, a significant and high expression of genes/proteins involved in keratinocyte host defense and inflammation was found in lesional skin. Furthermore, we detected several molecules, both up or downregulated in lesional skin, which are involved in epidermal differentiation. Immune signalling genes were found to be upregulated in lesional skin, albeit with relatively low expression levels. Non-lesional patient skin showed no significant differences compared to healthy control skin. Lesional vesicular hand eczema skin shows a distinct expression profile compared to non-lesional skin and healthy control skin. Notably, the overall results indicate a large overlap between vesicular hand eczema and earlier reported atopic dermatitis lesional transcriptome profiles, which suggests that treatments for atopic dermatitis could also be effective in (vesicular) hand eczema.

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Section: F I G U R E 1 Multivariate Gene Expression Analysis By Pcamentioning

confidence: 99%

Vesicular hand eczema transcriptome analysis provides insights into its pathophysiology

Voorberg

Niehues

Oosterhaven

et al. 2021

Experimental Dermatology

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“…The keratin IF network, particularly K14, can regulate keratinocyte rigidity sensing and nuclear mechanotransduction [174]. In inflammatory skin conditions, such as psoriasis, AD or ovalbumin-sensitized skin models in mice, the expression of the differentiation-related keratins K1 and K10 is downregulated, whereas keratins K6, K16, and K17 are induced [175][176][177]. The transcription of these "inflammatory" keratins can be promoted by the cytokine-and growth factor-activated pathways.…”

Section: Intermediate Filamentsmentioning

confidence: 99%

“…The transcription of these "inflammatory" keratins can be promoted by the cytokine-and growth factor-activated pathways. For example, the transcription of keratins K6 and K16 is induced by the epidermal growth factor (EGF), the tumor necrosis factor α (TNF-α), and IL-1, and that of keratins K17 and K7 is induced by IFN-γ [176].…”

Section: Intermediate Filamentsmentioning

confidence: 99%

Mechanotransduction in Skin Inflammation

Shutova

Boehncke

2022

Cells

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In the process of mechanotransduction, the cells in the body perceive and interpret mechanical stimuli to maintain tissue homeostasis and respond to the environmental changes. Increasing evidence points towards dysregulated mechanotransduction as a pathologically relevant factor in human diseases, including inflammatory conditions. Skin is the organ that constantly undergoes considerable mechanical stresses, and the ability of mechanical factors to provoke inflammatory processes in the skin has long been known, with the Koebner phenomenon being an example. However, the molecular mechanisms and key factors linking mechanotransduction and cutaneous inflammation remain understudied. In this review, we outline the key players in the tissue’s mechanical homeostasis, the available data, and the gaps in our current understanding of their aberrant regulation in chronic cutaneous inflammation. We mainly focus on psoriasis as one of the most studied skin inflammatory diseases; we also discuss mechanotransduction in the context of skin fibrosis as a result of chronic inflammation. Even though the role of mechanotransduction in inflammation of the simple epithelia of internal organs is being actively studied, we conclude that the mechanoregulation in the stratified epidermis of the skin requires more attention in future translational research.

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“…Usually, almost all types of skin cancers are related to environmental factors including contact with immense ultraviolet radiation or due to sun exposure. Environmental mutagens may be synthetic or natural agents in nature [74,[113][114][115][116]. these mutagens produce genetic mutations or expand mutational activities during the life span [117,118].…”

Section: Contribution Of Environmental Constituents In Mutationmentioning

confidence: 99%

“…It has also boost up or affected by deficient enzymes or transport proteins that are essential for lipid metabolism in the epidermis (cholesterol sulphatase, lipoxygenases, ABCA12, etc.). Mutations in epidermal keratins cause several skin diseases like congenital ichthyosis, epidermolytic ichthyosis, congenital bullous disease, corneal dystrophy, erythroderma, and pachyonychia congenital [74][75][76]. All the above diseases are due to mutation in the corneal keratin genes (KRT3, KRT12); mutation in simple epithelial keratin genes (KRT8/18, KRT19, KRT9); mutations in epithelial keratin genes (KRT6A, KRT6B, KRT6C, KRT16 or KRT17); mutations inKRT1 or KRT10 or basal layer keratinocytes genes (KRT5&KRT14) [77,78].…”

Section: Introductionmentioning

confidence: 99%

Contribution of Environmental Constituents in the Genomic Disruption of Cytokeratins

Sharma¹,

Kumawat²,

Sharma³

et al. 2021

Cytogenetics - Classical and Molecular Strategies for Analysing Heredity Material

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Cytokeratins are keratinous protein and assist cells to reduce mechanical stress on the intracytoplasmic layer of epithelial tissue. There are several unspecified mutations in the epithelial layer that may induces by environmental mutagens and pathogens. The unspecified mutations in the epithelium surface also disrupt biology of skin at multiple different levels and cause innate keratinizing disorders. These serve as a root generator of neurohormones and neuropeptides which mainly partake in the disruption. Generally, all 54 unique genes of human keratin partake in mutations and cause cutaneous tissue fragility, skin hypertrophic, and malignant transformation. In this chapter, unspecific factors that involved in the pathogenesis of skin diseases and the ways by which such keratin changes might harness to alleviate different skin conditions are also included. Consequently, the contribution of environmental changes in the frontier of mutations or misregulations of the cytokeratin genes, is also cited here.

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Regulation of Expression of Keratins and their Pathogenic Roles in Keratinopathies

Cited by 6 publications

References 28 publications

Vesicular hand eczema transcriptome analysis provides insights into its pathophysiology

Vesicular hand eczema transcriptome analysis provides insights into its pathophysiology

Mechanotransduction in Skin Inflammation

Contribution of Environmental Constituents in the Genomic Disruption of Cytokeratins

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