Regulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver

Yao, Xuan; Hou, Sarina; Zhang, Duo; Xia, Hongfeng; Wang, Yucheng; Jiang, Jingjing; Yin, Huiyong; Ying, Hao

doi:10.1186/2045-3701-4-38

Cited by 37 publications

(33 citation statements)

References 40 publications

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“…Our results also suggest that fat attenuation provides information that is independent of fat CSA. A recent study demonstrated that hypothyroidism in mice prevents accumulation of fat within the liver but leads to altered hepatic fatty acid composition and glycogen accumulation (27). In our study, patients with AN had normal thyroid-stimulating hormone levels but mildly decreased thyroxine levels.…”

Section: Hormonal Correlates Of Fat Attenuation and Csasupporting

confidence: 55%

Fat Attenuation at CT in Anorexia Nervosa

Gill

Torriani²,

Murphy³

et al. 2016

Radiology

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Section: Hormonal Correlates Of Fat Attenuation and Csasupporting

confidence: 55%

Fat Attenuation at CT in Anorexia Nervosa

Gill

Torriani²,

Murphy³

et al. 2016

Radiology

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“…Hepatic fatty acids contents were measured as previously described [33, 34]. In brief, about 20 mg liver tissue was homogenized in ice cold PBS.…”

Section: Methodsmentioning

confidence: 99%

Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease

Sun

et al. 2016

Oncotarget

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BackgroundOrganochlorine pesticides (OCPs) are one kind of persistent organic pollutants. Although they are reported to be associated with metabolic disorders, the underlying mechanism is unclear. We explored the association of OCPs with gallstone disease and its influence on hepatic lipid metabolism.Materials and MethodsOCPs levels in omentum adipose tissues from patients with and without gallstone disease between 2008 and 2011 were measured by GC-MS. Differences of gene expression involved in hepatic lipid metabolism and hepatic lipids content were compared in liver biopsies between groups with high and low level of OCPs. Using HepG2 cell lines, the influence on hepatic lipid metabolism by individual OCP was evaluated in vitro.ResultsIn all patients who were from non-occupational population, there were high levels of β-hexachlorocyclohexane (β-HCH) and p',p'-dichloroethylene (p',p'-DDE) accumulated in adipose tissues. Both β-HCH and p', p'-DDE levels were significantly higher in adipose tissues from patients with gallstone disease (294.3± 313.5 and 2222± 2279 ng/g of lipid) than gallstone-free controls (282.7± 449.0 and 2025±2664 ng/g of lipid, P< 0.01) and they were strongly related with gallstone disease (P for trend = 0.0004 and 0.0138). Furthermore, higher OCPs in adipose tissue led to increase in the expression of hepatic cholesterol transporters ABCG5 and G8 (+34% and +27%, P< 0.01) and higher cholesterol saturation index in gallbladder bile, and induced hepatic fatty acids synthesis, which was further confirmed in HepG2 cells.ConclusionOCPs might enhance hepatic secretion of cholesterol into bile via ABCG5/G8 which promoting gallstone disease as well as lipogenesis.

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“…Liver sections cut in cryostate were stained with Red Oil to reveal triacylglycerol droplets (TAG) [21]. The Sudan Black staining or the Kinyoun's Method were used for detecting lipofucsin granules (oxidative lipids) [22].…”

Section: Lipids Glycogen and Fibrosis Of The Livermentioning

confidence: 99%

Hypothyroidism Induces a Moderate Steatohepatitis Accompanied by Liver Regeneration, Mast Cells Infiltration, and Changes in the Expression of the Farnesoid X Receptor

Rodríguez-Castelán

Corona-Pérez

Nicolás-Toledo

et al. 2016

Exp Clin Endocrinol Diabetes

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Hypothyroidism is associated with the development of non-alcoholic steatohepatitis, but cellular mechanisms have been scarcely analyzed. Thyroid hormones regulate the synthesis and secretion of bile acids that are endogenous ligands of the farnesoid receptor (FXRα), which have been involved in the development of non-alcoholic steatohepatitis. However, the relationship between thyroid hormones and FXRα expression in the liver is yet unknown. Control (=6) and methimazole-induced hypothyroid (=6) female rabbits were used to evaluate the amount of lipids and glycogen, vascularization, hepatocytes proliferation, immune cells infiltration, and expression of FXRα. Student- or Mann-Whitney tests were carried out to determine significant differences. Hypothyroidism induced steatosis, glycogen loss, fibrosis, and a minor vascularization in the liver. In contrast, hypothyroidism increased the proliferation of hepatocytes and the infiltration of mast cells, but did not modify the number of immune cells into sinusoids. These changes were associated with a minor anti-FXRα immunoreactivity of periportal hepatocytes and pericentral immune cells. Our results suggest that hypothyroidism induces a moderate non-alcoholic steatohepatitis, alllowing the hepatic regeneration. The FXRα may be involved in the development of non-alcoholic steatohepatitis in hypothyroid subjects.

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Regulation of fatty acid composition and lipid storage by thyroid hormone in mouse liver

Cited by 37 publications

References 40 publications

Fat Attenuation at CT in Anorexia Nervosa

Fat Attenuation at CT in Anorexia Nervosa

Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease

Hypothyroidism Induces a Moderate Steatohepatitis Accompanied by Liver Regeneration, Mast Cells Infiltration, and Changes in the Expression of the Farnesoid X Receptor

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