Regulation of FcεRI Expression on Monocytic Cell Lines

IgE and FcεRI Regulation

“…For example, it is not uncommon to observe 500,000 FcεRI on circulating basophils of atopics and a maximum of 5000 receptors (and sometimes considerably less) on their monocytes. Because the expression of the receptors on monocytes and dendritic cells is also under the influence of circulating IgE (this form of regulating receptor expression seems intact2,25–28), it is possible that the absence of FcεRIβ restricts the cell's ability to load its cell surface with high densities of FcεRI. Studies with transfected cell lines demonstrate that coexpression of FcεRIβ leads to lines that express higher densities of FcεRI, although these studies would not suggest such a marked difference in expression levels in cells expressing αγ 2 versus αβγ 2 .…”

“…For example, it is not known how much IgE must be bound to dendritic or Langerhans cells to initiate substantial antigen presentation. Furthermore, the relationship between IgE concentration and expression of FcεRI on these cells is not well understood, although it is apparent that the relationship exists 2,25–27. Therefore, a prediction of how changes in IgE might alter the response of these cells cannot be made at this time.…”

“…Furthermore, the relationship between IgE concentration and expression of FcεRI on these cells is not well understood, although it is apparent that the relationship exists. 2,[25][26][27] Therefore, a prediction of how changes in IgE might alter the response of these cells cannot be made at this time.…”